ID I3MK76_ICTTR Unreviewed; 876 AA.
AC I3MK76;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=Taste receptor type 1 member 3 {ECO:0000256|ARBA:ARBA00040705};
GN Name=TAS1R3 {ECO:0000313|Ensembl:ENSSTOP00000011664.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000011664.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000011664.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family. TAS1R
CC subfamily. {ECO:0000256|ARBA:ARBA00038492}.
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DR EMBL; AGTP01101335; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; I3MK76; -.
DR STRING; 43179.ENSSTOP00000011664; -.
DR Ensembl; ENSSTOT00000013016.3; ENSSTOP00000011664.3; ENSSTOG00000013015.3.
DR eggNOG; KOG1056; Eukaryota.
DR GeneTree; ENSGT00940000160679; -.
DR HOGENOM; CLU_005389_1_0_1; -.
DR InParanoid; I3MK76; -.
DR TreeFam; TF331269; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:1903767; C:sweet taste receptor complex; IEA:Ensembl.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0033041; F:sweet taste receptor activity; IEA:Ensembl.
DR GO; GO:0050917; P:sensory perception of umami taste; IEA:Ensembl.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24061:SF435; TASTE RECEPTOR TYPE 1 MEMBER 3; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00592; CASENSINGR.
DR PRINTS; PR00248; GPCRMGR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..876
FT /note="Taste receptor type 1 member 3"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013152925"
FT TRANSMEM 582..605
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 617..638
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 694..715
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 741..765
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 777..796
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 802..823
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 582..839
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 849..876
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 876 AA; 96362 MW; 5815ED60B100B97C CRC64;
MPGLAVLGLL LAALLGLGTG TSLCLSRQLR MQGDYMLGGL FPLGSAEEAS LRHRTRPSGI
VCTRFSSLGL FLAMAVKMAV EEINNSSTLL PGLHLGYDLF DTCSEPMVTM KPSLMFLAEA
GNSSIAAYCN YTQYQPRVLA VIGPHSSELA LITGKFFSFF LMPQVSYGAS MDRLSNRDTF
PSFFRTVPSD RVQLEAVVKL LQKFEWNWVA ALGSDDEYGR EGLSIFSGLA NAQNICIAHE
GLVPLLGADT LKLDKVLDVL RQVNQSNVQV VVLFASSRAA HALLHYSIHH NLSPKVWVAS
EAWLTSDLVM TLPGIAQVGT VLGFLQRGVQ LPEFSQYVEM QLALASDPAF CASLDDKPDL
EEHVVGPRCP QCDHITLRNL STGLLQNLSA GQLHHQIFAT YAAVYSVAQA LHNTLQCSPT
SCPAREPVRP WQLLENMYNM SFRARGLALQ FDSKGNVDME YDLKMWVWQK PTPRLHTVGT
FNGSLWLQPS QMHWHMPGNQ VPASQCSRQC EEGQVRRVKG FHSCCYDCVD CKAGNYRPQH
PLSYPPTDDF VCTPCGQDQW SPERSTRCFP RRPRFLAWGE PAVLLLLLLL SLVLGLTLAA
LGLFACHWDS PLVQASGGPL ACFGLACLGL VCLSVLLFPG RPGPASCLAQ QPLAHLPLTG
CLSTLFLKAA ETFVESELPP NWATRLHGCL RGPWAWLVVL LAILTEAVLC AWYLVAFTPE
VMTDWRVLPT EALVHCHMRS WVSLGLVHIT NALLAFLCFL GTFLVQSQPG RYNHARGLTF
AMLAYFITWV SFVPLLTNVQ VVYQPAVQMG AILLCALGIL AAFHLPKCYL LLWWPRLNTP
EFFLGAGPGD ARDRGRSGSS EGPQGNEGPF TPHPHT
//
