ID I3MLE7_ICTTR Unreviewed; 872 AA.
AC I3MLE7;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Espin {ECO:0000313|Ensembl:ENSSTOP00000012230.3};
GN Name=ESPN {ECO:0000313|Ensembl:ENSSTOP00000012230.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000012230.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000012230.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, stereocilium
CC {ECO:0000256|ARBA:ARBA00004645}.
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DR EMBL; AGTP01079019; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01079020; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01079021; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; I3MLE7; -.
DR STRING; 43179.ENSSTOP00000012230; -.
DR Ensembl; ENSSTOT00000013650.3; ENSSTOP00000012230.3; ENSSTOG00000013645.3.
DR eggNOG; KOG0504; Eukaryota.
DR GeneTree; ENSGT00940000160408; -.
DR HOGENOM; CLU_017441_0_0_1; -.
DR InParanoid; I3MLE7; -.
DR TreeFam; TF326392; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005902; C:microvillus; IEA:Ensembl.
DR GO; GO:0032420; C:stereocilium; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0030034; P:microvillar actin bundle assembly; IEA:Ensembl.
DR GO; GO:0007605; P:sensory perception of sound; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR003124; WH2_dom.
DR PANTHER; PTHR24153; ESPIN; 1.
DR PANTHER; PTHR24153:SF14; ESPIN ISOFORM X1; 1.
DR Pfam; PF12796; Ank_2; 3.
DR Pfam; PF02205; WH2; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 8.
DR SMART; SM00246; WH2; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 6.
DR PROSITE; PS50088; ANK_REPEAT; 6.
DR PROSITE; PS51082; WH2; 1.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Hearing {ECO:0000256|ARBA:ARBA00022740};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 69..93
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 103..127
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 171..193
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 205..227
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 239..268
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 271..307
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 674..691
FT /note="WH2"
FT /evidence="ECO:0000259|PROSITE:PS51082"
FT REGION 341..399
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 417..464
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 480..752
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 822..851
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 427..460
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 500..514
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 516..530
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 615..644
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 651..674
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 691..717
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 721..752
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 872 AA; 93576 MW; 8A81C87C2635A446 CRC64;
MALEQALQAA RQGDLDVLRS LHAANLLGPS LRDPLDALPV HHAARAGKLH CLRFLVEEAG
LPAAARARNG ATPAHDAAAT GHLACLQWLL SQGGCRVQDK DNSGATVLHL AARFGHPEVV
NWLLRYGGGE PTMATDTGAL PVHYAAAKGD FPSLRLLVGH YPEGVNAQTK NGATPLYLAC
QEGHLEVTQY LVQECGADPH ARAHDGMTPL HAAAQMGHSS VIVWLVSCTD VSLSEQDKDG
ATAMHFAASR GHAKVLSWLL LHGGEISADL WGGTPLHDAA ENGAHPMPPQ CCQILVVNGA
ELDVRDRDGY TAADLSDYNG HSHCTRYLRT VENLSVEHRV LSQDSSTELE AKQPDSGMSS
PNTTMSVQPQ NFDLSSPAST LSNYDSCSSS HSSIKGQRLS SARAADIQNY MDMLNPELGL
SQGKMGRSVP PPPPPSFPPP PPPPGTQLPP PPPGYPAPNP PVGLHAADIY MQTKNKLRHV
ETEPLKKEKS WGRGRCGVLG TSGQSPSVFP QPSSRDHHNG LRRQDSGRKS RTFIKQPSTG
DYYRQLGRCT GEPLAARPGM AHSEEVRALQ PAPAGRPGSG PAARASLASP SAPPQAALLP
GNHVQNGCTA DSKPSRELPP PPPPPPPPPP EAQSSLPPAP PLPLEGAGSG CGQRRSSSST
GSTKSFNMMS PTGDNSELLA EIKAGKSLKP TPQSKGLTTV FSGSRQPATQ HDTQVPPVSP
APSRARSPTP PAVGPQPLLN GSIVPAPPAT PAPGVQLNVE TLVPVHDEQG RPIPEWKRQV
MVRKLMVKMQ EEEEQKRKEE EEEARLASLP AWRRDLLRKK MEEERKEEER QKQEEIQREK
EQSEKLRTLG YDESKLAPWQ RQVILKKGDI PK
//
