ID I3MYH6_ICTTR Unreviewed; 630 AA.
AC I3MYH6;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Keratin 3 {ECO:0000313|Ensembl:ENSSTOP00000017172.2};
GN Name=KRT3 {ECO:0000313|Ensembl:ENSSTOP00000017172.2};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000017172.2, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000017172.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AGTP01037447; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01037448; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; I3MYH6; -.
DR Ensembl; ENSSTOT00000022557.2; ENSSTOP00000017172.2; ENSSTOG00000021897.2.
DR GeneTree; ENSGT00940000162629; -.
DR HOGENOM; CLU_012560_6_1_1; -.
DR TreeFam; TF317854; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR032444; Keratin_2_head.
DR InterPro; IPR003054; Keratin_II.
DR PANTHER; PTHR45616; GATA-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45616:SF38; KERATIN, TYPE II CYTOSKELETAL 3; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF16208; Keratin_2_head; 2.
DR PRINTS; PR01276; TYPE2KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 3.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685}; Keratin {ECO:0000256|ARBA:ARBA00022744};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215}.
FT DOMAIN 201..516
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 601..630
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 205..239
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 272..341
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 414..494
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..34
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 604..630
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 630 AA; 64510 MW; 66ADE82EC2B30D91 CRC64;
MSRQAGKKSI SSGSQGFSGR SAVVTGSSRM SGVTRSRAAG GGASGLRGTA GGFGSRSLYN
LGGNKSISFS VAAGGSRAGG FGGGRSIYVS GFGGGYGGGF GSGYGGGFGG GLGGGRGMGG
GLGGAGGLGG AGGLGGAGGF GGLGGLGGLG GLGGPGGFGG PGGFGPGSFP GGIQEVTINQ
SLLQPLNVEI DPQIGQVKAQ EREQIKTLNN KFASFIDKVR FLEQQNKVLE TKWELLQQQG
TNSITGTNNL EPLFENHINY LRNYLDSILG ERGRLDSELR NMQDLVEDFK KKYEDEINKR
TAAENEFVTL KKDVDAAYMN KVELQAKVDA LMDEINFLRT LYDAELSQMQ SHVSDTSVIL
SMDNNRNLDL DSIIAEVRAQ YEDIAQRSKA EAEALYQTKL GELQSTAGRH GDDLKSTKSE
IMELNRMIQR LRAEIENIKK QNANLQTSIA EAEQRGEMAL KDANAKLQDL QAALQQAKDD
LARLLRDYQE LMNVKLALDV EIATYRKLLE GEECRMSGEC PSAVSISVVN SSSTTSASAG
GYGGGYGGGL GVGGGAGSGF GLGGGSGLGG GSGLGGGIGI GLGGGSGFGV GSGLGGGRGG
VSGGGFSSGS TRGSSIKSSQ ISQSSQRYIR
//
