ID I3N2P6_ICTTR Unreviewed; 1313 AA.
AC I3N2P6;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Contactin-associated protein-like 3 {ECO:0000313|Ensembl:ENSSTOP00000018642.2};
GN Name=LOC101975743 {ECO:0000313|Ensembl:ENSSTOP00000018642.2};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000018642.2, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000018642.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the neurexin family.
CC {ECO:0000256|ARBA:ARBA00010241}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; AGTP01104965; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01104966; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01104967; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01104968; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01104969; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01104970; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 43179.ENSSTOP00000018642; -.
DR Ensembl; ENSSTOT00000021277.2; ENSSTOP00000018642.2; ENSSTOG00000006516.3.
DR eggNOG; KOG3516; Eukaryota.
DR GeneTree; ENSGT00940000157674; -.
DR HOGENOM; CLU_003504_1_0_1; -.
DR InParanoid; I3N2P6; -.
DR OrthoDB; 4255614at2759; -.
DR TreeFam; TF321823; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00057; FA58C; 1.
DR CDD; cd00110; LamG; 4.
DR Gene3D; 2.60.120.1000; -; 1.
DR Gene3D; 2.60.120.200; -; 4.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR036056; Fibrinogen-like_C.
DR InterPro; IPR002181; Fibrinogen_a/b/g_C_dom.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR001791; Laminin_G.
DR NCBIfam; NF040941; GGGWT_bact; 1.
DR PANTHER; PTHR15036:SF36; CONTACTIN-ASSOCIATED PROTEIN-LIKE 3-RELATED; 1.
DR PANTHER; PTHR15036; PIKACHURIN-LIKE PROTEIN; 1.
DR Pfam; PF00754; F5_F8_type_C; 1.
DR Pfam; PF02210; Laminin_G_2; 4.
DR SMART; SM00181; EGF; 2.
DR SMART; SM00231; FA58C; 1.
DR SMART; SM00282; LamG; 4.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 4.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF56496; Fibrinogen C-terminal domain-like; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS01285; FA58C_1; 1.
DR PROSITE; PS01286; FA58C_2; 1.
DR PROSITE; PS50022; FA58C_3; 1.
DR PROSITE; PS51406; FIBRINOGEN_C_2; 1.
DR PROSITE; PS50025; LAM_G_DOMAIN; 4.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00122}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..1313
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5011977291"
FT TRANSMEM 1246..1269
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 31..177
FT /note="F5/8 type C"
FT /evidence="ECO:0000259|PROSITE:PS50022"
FT DOMAIN 183..364
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 370..546
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 548..585
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 584..635
FT /note="Fibrinogen C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51406"
FT DOMAIN 792..957
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 958..996
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1018..1204
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT REGION 1219..1238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 930..957
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00122"
SQ SEQUENCE 1313 AA; 143572 MW; 97B4FC8086CE7F50 CRC64;
MDPVAGALLK MLALLSAQTC SKVVAGNTYN CNAPLASALP RVSFSSSSEL SSSHGPGFAS
LNRRDGAGGW TPLVSNKYQW LQIDLGERMK VTAVATQGGY GSSDWVTRYL LMFSDSGRNW
KQYRREESFW GFPGNTNSDS VVHYRLQPPL EARFLRFLPL AWNSKGRIGM RIEVYGCAYR
SEMVNFDGKS FLLYTINQKS ISSMKEIITL KFKTRQSDGI LLHREGQNGK HITLELVKGK
LILFFNSGGA NLPSLDAQVT LTLGSLLDDQ HWHSVLIEVL NTHINFTVDK HTHRFQAEGE
ASLLDLGYKI SFGGIPGLGK SLVFPHKSFN GCFENLFYNG VDIIDLSKKH KPEILIMGNM
SFSCSHPQTV PVTFLSSRSY LALPHPTGEN SVAVTFQFRT WNRAGLLLKS QFLHWSGALV
LVLSDGKLKL SLCPPGQPVR AVIAGDGLND GQWHSVSLSA NGNHLSLKVD NDASSAAHSR
RGQIHSANTY YFGGYPDNSS GSQCENPLRG FQGCLKLISI GGTVVDPISV QQGELGNFRD
LQIDSCGITD RCLPSYCEHG GECSQSWDTF SCDCTHTGYV GATCHSSLYE RSCEAYKHRG
NSSGFYYIDS DGSGPLGPAL VYCNMTDSAW TSVQHNGSHL ARVKSSHGES PQPVIFKYMA
SMDQLQALID QADHCQQELA FHCKKSRLSA HLDGTPVSWW VGRTNETHTY WGGSLPDAQK
CTCGLEGNCI DSQYHCNCDA DQDEWTSDTG VLSHKEHLPV TQVMMTDAGR PQSEAAYTLG
PLLCRGDNSF WNSASFNTET SYLHFPTFRG ELSADVSFFF KTTASSGVFV ENLGITDFIR
LELRAPTEVT FSFDVGNGPC EVTVQSPTPF NDNRWHHVKA ERNVKEASLQ VDQLPQKFQP
APTGGHLLLQ LNSQLFIGGT ASRQRGFLGC IRFLQLNGIA LDLEGRAKVT PGVEAGCAGH
CSSYGHLCHN GGRCQERHRG VACDCTSSAY EGPFCSHEIS AYFGAGSSII YSFQEHHNYT
FNGNSSSLAA LFHEELTLTR EIVTLSFRTT GTPSLLLFVS SVYEEYLSVI LASNGSLQIR
YKLDRHREPD VFNFDFKNLA DGQLHNVKIN REAAVVFVEV NQNARRRATL SSGMEFNAVK
SLVLGMILEP PGADPDTQRA AARGFTGCLS AVRFSHAAPL KAALRLGGPV PVTVHGQVAA
GSRCAAGAGP GSRVRELAPR LSDGSGYSGP TDEGEPLINA DRSDSAVIGG VVAVVIFILL
CVTAIAIRIC QQRWLYQKNE SDISKAGDNA EIALKSELNM QNTVSESQKE YFF
//
