ID I3N892_ICTTR Unreviewed; 822 AA.
AC I3N892;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Helicase, lymphoid specific {ECO:0000313|Ensembl:ENSSTOP00000020588.1};
GN Name=HELLS {ECO:0000313|Ensembl:ENSSTOP00000020588.1};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000020588.1, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000020588.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AGTP01072841; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01072842; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; I3N892; -.
DR STRING; 43179.ENSSTOP00000020588; -.
DR Ensembl; ENSSTOT00000021269.2; ENSSTOP00000020588.1; ENSSTOG00000021976.2.
DR eggNOG; KOG0385; Eukaryota.
DR GeneTree; ENSGT00740000115593; -.
DR HOGENOM; CLU_000315_17_3_1; -.
DR InParanoid; I3N892; -.
DR OMA; PNIFTDW; -.
DR TreeFam; TF329077; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0005721; C:pericentric heterochromatin; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR GO; GO:0006915; P:apoptotic process; IEA:Ensembl.
DR GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IEA:Ensembl.
DR GO; GO:0006306; P:DNA methylation; IEA:Ensembl.
DR GO; GO:0006346; P:DNA methylation-dependent heterochromatin formation; IEA:Ensembl.
DR GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR GO; GO:0046651; P:lymphocyte proliferation; IEA:Ensembl.
DR GO; GO:0044027; P:negative regulation of gene expression via CpG island methylation; IEA:Ensembl.
DR GO; GO:2001243; P:negative regulation of intrinsic apoptotic signaling pathway; IEA:Ensembl.
DR GO; GO:0031508; P:pericentric heterochromatin formation; IEA:Ensembl.
DR GO; GO:0001655; P:urogenital system development; IEA:Ensembl.
DR CDD; cd18009; DEXHc_HELLS_SMARCA6; 1.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR044753; HELLS_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR47161; LYMPHOID-SPECIFIC HELICASE; 1.
DR PANTHER; PTHR47161:SF1; LYMPHOID-SPECIFIC HELICASE; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215}.
FT DOMAIN 219..387
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 587..737
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 99..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 67..94
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 822 AA; 95412 MW; 44EDBCBFF65418C4 CRC64;
MVEQEETAVI TPAMLEEETQ LEAAGLERER KMMEKARMSW DRESTEIRYR RLQHLLEKSN
IYSKFLLTKM EQQQLEEQKK KEKLERKKES LKVTKGKKLV GGSGENAAMK KKRGREEESY
NISEVMTKEE ILSVAKKNKK EKEDESSSSA NLCVEDLQKN KDSNSMIKDR LSQTVRQNAK
FFFDPVRKCN GQPVPFQQPK YFTGGVMRWY QVEGMEWLRM LWENGINGIL ADEMGLGKTV
QCIATIALMI QRGVPGPFLV CGPLSTLPNW MAEFKRFTPE IPTMLYHGTQ EERQKLVRNI
HKRKGTLQIH PVVITSFEIA MRDRNALQHC YWKYLIVDEG HRIKNMKCRL IRELKRFNAD
NKLLLTGTPL QNNLSELWSL LNFLLPDVFD DLKSFESWFD ITSLSETAED IIAKEREQNV
LHMLHQILTP FLLRRLKSDV ALEVPPKREV VVYAPLSKKQ EVFYTAIVNR TIANMFGTSE
KETVELSPTG RPKRRTRKSI NYSKIDNFPN ELEKLISQIQ PEVDRERTVV EVNSPIESEV
NLKLQNIMML LRKCCNHPYL IEYPIDPVTQ EFKIDEELVT NSGKFLILDR MLPELKKRGH
KVLLFSQMTR MLDILMDYCH LRNFNFSRLD GSMSYSEREE NMHSFNTDPD VFIFLVSTRA
GGLGINLTAA DTVIIYDSDW NPQSDLQAQD RCHRIGQTKP VVVYRLVTAN TIDQKIVERA
AAKRKLEKLI IHKNHFKGGQ SGLNQSKNFL DPKELKELLK SRDYEREVKG SREKVISDKD
LELLLDRSDL IDQMKASGPI KEKTGIFKIL ENSEDSSPEC LF
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