ID I3NN38_NOTVI Unreviewed; 234 AA.
AC I3NN38;
DT 05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2012, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Homeobox C6 {ECO:0000313|EMBL:ADZ04664.1};
GN Name=HoxC6 {ECO:0000313|EMBL:ADZ04664.1};
OS Notophthalmus viridescens (Eastern newt) (Triturus viridescens).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Caudata; Salamandroidea; Salamandridae; Pleurodelinae;
OC Notophthalmus.
OX NCBI_TaxID=8316 {ECO:0000313|EMBL:ADZ04664.1};
RN [1] {ECO:0000313|EMBL:ADZ04664.1}
RP NUCLEOTIDE SEQUENCE.
RA Voss S.R., Putta S., Walker J.A., Smith J.J., Maki N., Tsonis P.A.;
RT "Salamander Hox Clusters Contain Repetitive DNA and Expanded Non-Coding
RT Regions: A Typical Hox Structure for Non-Mammalian Tetrapod Vertebrates?";
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the Antp homeobox family.
CC {ECO:0000256|ARBA:ARBA00009107}.
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DR EMBL; JF490017; ADZ04664.1; -; Genomic_DNA.
DR AlphaFoldDB; I3NN38; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR PANTHER; PTHR45659; HOMEOBOX PROTEIN HOX; 1.
DR PANTHER; PTHR45659:SF1; HOMEOBOX PROTEIN HOX-C6; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00032; ANTENNAPEDIA; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 139..199
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 141..200
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 200..234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 217..234
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 234 AA; 26870 MW; 42D82D17160054B6 CRC64;
MNSYFTNPSL SCHLASGQEV LPNVALNSSA YDPVRHFSTY GAAVAQNRIY SSPFYSPQDN
VVFSSGRGPY EYGSNAFYQD KDMLSSCRQN AMGHNTQTSI AQDFSSDQSR ASVQEQKTSI
QIYPWMQRMN SHSGVGYGTD RRRGRQIYSR YQTLELEKEF HFNRYLTRRR RIEIANALCL
TERQIKIWFQ NRRMKWKKES NLTSTLSGGT GAASDSLAEG KEKEEETEEE QQKE
//
