ID I3P6K3_9PAPI Unreviewed; 138 AA.
AC I3P6K3;
DT 05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2012, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Protein E6 {ECO:0000256|HAMAP-Rule:MF_04006, ECO:0000256|RuleBase:RU363123};
GN Name=E6 {ECO:0000256|HAMAP-Rule:MF_04006,
GN ECO:0000313|EMBL:AEM24593.1};
OS Human papillomavirus 135.
OC Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes;
OC Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae;
OC Gammapapillomavirus; Gammapapillomavirus 15.
OX NCBI_TaxID=1070408 {ECO:0000313|EMBL:AEM24593.1, ECO:0000313|Proteomes:UP000144657};
RN [1] {ECO:0000313|EMBL:AEM24593.1, ECO:0000313|Proteomes:UP000144657}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NJ3500 {ECO:0000313|EMBL:AEM24593.1};
RX PubMed=21844305; DOI=10.1093/infdis/jir383;
RA Bottalico D., Chen Z., Dunne A., Ostoloza J., McKinney S., Sun C.,
RA Schlecht N.F., Fatahzadeh M., Herrero R., Schiffman M., Burk R.D.;
RT "The oral cavity contains abundant known and novel human papillomaviruses
RT from the Betapapillomavirus and Gammapapillomavirus genera.";
RL J. Infect. Dis. 204:787-792(2011).
CC -!- FUNCTION: Plays a major role in the induction and maintenance of
CC cellular transformation. E6 associates with host UBE3A/E6-AP ubiquitin-
CC protein ligase and modulates its activity. Protects host keratinocytes
CC from apoptosis by mediating the degradation of host BAK1. May also
CC inhibit host immune response. {ECO:0000256|HAMAP-Rule:MF_04006}.
CC -!- SUBUNIT: Forms homodimers. Interacts with ubiquitin-protein ligase
CC UBE3A/E6-AP; this interaction stimulates UBE3A ubiquitin activity.
CC Interacts with host BAK1. {ECO:0000256|HAMAP-Rule:MF_04006}.
CC -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000256|HAMAP-Rule:MF_04006,
CC ECO:0000256|RuleBase:RU363123}. Host nucleus {ECO:0000256|HAMAP-
CC Rule:MF_04006, ECO:0000256|RuleBase:RU363123}.
CC -!- SIMILARITY: Belongs to the papillomaviridae E6 protein family.
CC {ECO:0000256|ARBA:ARBA00006346, ECO:0000256|HAMAP-Rule:MF_04006,
CC ECO:0000256|RuleBase:RU363123}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|HAMAP-Rule:MF_04006}.
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DR EMBL; HM999987; AEM24593.1; -; Genomic_DNA.
DR RefSeq; YP_006393281.1; NC_017993.1.
DR GeneID; 12983960; -.
DR KEGG; vg:12983960; -.
DR OrthoDB; 27353at10239; -.
DR Proteomes; UP000144657; Genome.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0039648; P:modulation by symbiont of host protein ubiquitination; IEA:UniProtKB-UniRule.
DR GO; GO:0039526; P:perturbation by virus of host apoptosis; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.240.40; E6 early regulatory protein; 2.
DR HAMAP; MF_04006; HPV_E6; 1.
DR InterPro; IPR001334; E6.
DR InterPro; IPR038575; E6_sf.
DR Pfam; PF00518; E6; 1.
DR SUPFAM; SSF161229; E6 C-terminal domain-like; 2.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|HAMAP-Rule:MF_04006};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_04006};
KW Early protein {ECO:0000256|ARBA:ARBA00022518, ECO:0000256|HAMAP-
KW Rule:MF_04006};
KW Host cytoplasm {ECO:0000256|ARBA:ARBA00023200, ECO:0000256|HAMAP-
KW Rule:MF_04006};
KW Host nucleus {ECO:0000256|HAMAP-Rule:MF_04006,
KW ECO:0000256|RuleBase:RU363123};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581, ECO:0000256|HAMAP-
KW Rule:MF_04006};
KW Inhibition of host innate immune response by virus
KW {ECO:0000256|ARBA:ARBA00022632, ECO:0000256|HAMAP-Rule:MF_04006};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|HAMAP-
KW Rule:MF_04006};
KW Modulation of host cell apoptosis by virus {ECO:0000256|ARBA:ARBA00023323,
KW ECO:0000256|HAMAP-Rule:MF_04006};
KW Reference proteome {ECO:0000313|Proteomes:UP000144657};
KW Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW Rule:MF_04006};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW Rule:MF_04006};
KW Viral immunoevasion {ECO:0000256|ARBA:ARBA00023280, ECO:0000256|HAMAP-
KW Rule:MF_04006};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|HAMAP-Rule:MF_04006};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|HAMAP-
KW Rule:MF_04006}.
FT ZN_FING 27..63
FT /evidence="ECO:0000256|HAMAP-Rule:MF_04006"
FT ZN_FING 100..136
FT /evidence="ECO:0000256|HAMAP-Rule:MF_04006"
SQ SEQUENCE 138 AA; 15926 MW; E1EBBA8ADF092434 CRC64;
MEGTQPRSLD EYCSVFKVDF FNVRLRCIFC LFYASLTDLA NFFDKKLSIV WRGDTPYVCC
IRCARHSAKI DREKYTLCAV KCDILDAVVG KPLKEIVIRC SACFALLDQA EKLDACAREQ
LVLLIRGHWR TECRLCKV
//
