ID I3TIB7_TISMK Unreviewed; 422 AA.
AC I3TIB7;
DT 05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2012, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=TRAP transporter large permease protein {ECO:0000256|RuleBase:RU369079};
GN Name=siaT {ECO:0000313|EMBL:AFK52505.1};
GN OrderedLocusNames=TMO_0666 {ECO:0000313|EMBL:AFK52505.1};
OS Tistrella mobilis (strain KA081020-065).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Geminicoccales;
OC Geminicoccaceae; Tistrella.
OX NCBI_TaxID=1110502 {ECO:0000313|EMBL:AFK52505.1, ECO:0000313|Proteomes:UP000005258};
RN [1] {ECO:0000313|EMBL:AFK52505.1, ECO:0000313|Proteomes:UP000005258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KA081020-065 {ECO:0000313|EMBL:AFK52505.1,
RC ECO:0000313|Proteomes:UP000005258};
RX PubMed=22458477; DOI=10.1021/ja301735a;
RA Xu Y., Kersten R.D., Nam S.J., Lu L., Al-Suwailem A.M., Zheng H.,
RA Fenical W., Dorrestein P.C., Moore B.S., Qian P.Y.;
RT "Bacterial biosynthesis and maturation of the didemnin anti-cancer
RT agents.";
RL J. Am. Chem. Soc. 134:8625-8632(2012).
CC -!- FUNCTION: Part of the tripartite ATP-independent periplasmic (TRAP)
CC transport system. {ECO:0000256|RuleBase:RU369079}.
CC -!- SUBUNIT: The complex comprises the extracytoplasmic solute receptor
CC protein and the two transmembrane proteins.
CC {ECO:0000256|RuleBase:RU369079}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429, ECO:0000256|RuleBase:RU369079}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004429,
CC ECO:0000256|RuleBase:RU369079}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TRAP transporter large permease family.
CC {ECO:0000256|RuleBase:RU369079}.
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DR EMBL; CP003236; AFK52505.1; -; Genomic_DNA.
DR RefSeq; WP_014744185.1; NC_017956.1.
DR AlphaFoldDB; I3TIB7; -.
DR STRING; 1110502.TMO_0666; -.
DR KEGG; tmo:TMO_0666; -.
DR PATRIC; fig|1110502.3.peg.690; -.
DR eggNOG; COG1593; Bacteria.
DR HOGENOM; CLU_019824_4_0_5; -.
DR Proteomes; UP000005258; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR InterPro; IPR010656; DctM.
DR InterPro; IPR004681; TRAP_DctM.
DR NCBIfam; TIGR00786; dctM; 1.
DR PANTHER; PTHR33362:SF5; C4-DICARBOXYLATE TRAP TRANSPORTER LARGE PERMEASE PROTEIN DCTM; 1.
DR PANTHER; PTHR33362; SIALIC ACID TRAP TRANSPORTER PERMEASE PROTEIN SIAT-RELATED; 1.
DR Pfam; PF06808; DctM; 1.
DR PIRSF; PIRSF006066; HI0050; 1.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519,
KW ECO:0000256|RuleBase:RU369079};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU369079};
KW Reference proteome {ECO:0000313|Proteomes:UP000005258};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU369079};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU369079}; Transport {ECO:0000256|RuleBase:RU369079}.
FT TRANSMEM 6..34
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369079"
FT TRANSMEM 46..69
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369079"
FT TRANSMEM 89..122
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369079"
FT TRANSMEM 134..153
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369079"
FT TRANSMEM 165..190
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369079"
FT TRANSMEM 214..231
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369079"
FT TRANSMEM 237..256
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369079"
FT TRANSMEM 268..289
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369079"
FT TRANSMEM 309..340
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369079"
FT TRANSMEM 352..373
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369079"
FT TRANSMEM 393..417
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369079"
FT DOMAIN 7..412
FT /note="TRAP C4-dicarboxylate transport system permease DctM
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF06808"
SQ SEQUENCE 422 AA; 44517 MW; 49C6D7A3C42C3555 CRC64;
MTFLLILVGV VLVLLTGLPV FTGLGLFAGG LLLVTQGDLG ALGEVVFGQL DSYLLVAIPL
FTLMAHIMIR GRVVDDLYGT AHTLLRHLPG GIGIATVFAC TIFAAISGSS IATALTVGAV
AIPQMIHYGY KPRVAYGVVA AGGTLGILIP PSGPMVLYGV ISDTSIGGLF MAGILPGLMI
AVLFAVWCAV NDRGTLRQPR ASLWEMGRAL RKSGWALSLP VFVLGGMYAG VFTATEAAAA
GALAALVVSA VIYRNFGLRD LWASAMDSVR TSAMLFMILA AAGVFGHVLT KMRVPQQIVE
LVVHWDVGVA GFLIAMMVLI ALLGMFLETI SIILITTPVV LPVMAHLGIN PIWYGILLTI
NLELALITPP VGMNLFTIKA VAKAPMGEVI RGVAPYVFLM VIGLVLVMIW PDIALWLPST
MR
//
