ID I3TM11_TISMK Unreviewed; 134 AA.
AC I3TM11;
DT 05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2012, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Methylmalonyl-CoA epimerase {ECO:0000313|EMBL:AFK53799.1};
GN OrderedLocusNames=TMO_1961 {ECO:0000313|EMBL:AFK53799.1};
OS Tistrella mobilis (strain KA081020-065).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Geminicoccales;
OC Geminicoccaceae; Tistrella.
OX NCBI_TaxID=1110502 {ECO:0000313|EMBL:AFK53799.1, ECO:0000313|Proteomes:UP000005258};
RN [1] {ECO:0000313|EMBL:AFK53799.1, ECO:0000313|Proteomes:UP000005258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KA081020-065 {ECO:0000313|EMBL:AFK53799.1,
RC ECO:0000313|Proteomes:UP000005258};
RX PubMed=22458477; DOI=10.1021/ja301735a;
RA Xu Y., Kersten R.D., Nam S.J., Lu L., Al-Suwailem A.M., Zheng H.,
RA Fenical W., Dorrestein P.C., Moore B.S., Qian P.Y.;
RT "Bacterial biosynthesis and maturation of the didemnin anti-cancer
RT agents.";
RL J. Am. Chem. Soc. 134:8625-8632(2012).
CC -!- SIMILARITY: Belongs to the methylmalonyl-CoA epimerase family.
CC {ECO:0000256|ARBA:ARBA00009308}.
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DR EMBL; CP003236; AFK53799.1; -; Genomic_DNA.
DR RefSeq; WP_014745477.1; NC_017956.1.
DR AlphaFoldDB; I3TM11; -.
DR STRING; 1110502.TMO_1961; -.
DR KEGG; tmo:TMO_1961; -.
DR PATRIC; fig|1110502.3.peg.2021; -.
DR eggNOG; COG0346; Bacteria.
DR HOGENOM; CLU_046006_5_0_5; -.
DR Proteomes; UP000005258; Chromosome.
DR CDD; cd07249; MMCE; 1.
DR Gene3D; 3.10.180.10; 2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1; 1.
DR InterPro; IPR029068; Glyas_Bleomycin-R_OHBP_Dase.
DR InterPro; IPR017515; MeMalonyl-CoA_epimerase.
DR InterPro; IPR037523; VOC.
DR NCBIfam; TIGR03081; metmalonyl_epim; 1.
DR PANTHER; PTHR43048; METHYLMALONYL-COA EPIMERASE; 1.
DR PANTHER; PTHR43048:SF3; METHYLMALONYL-COA EPIMERASE, MITOCHONDRIAL; 1.
DR Pfam; PF13669; Glyoxalase_4; 1.
DR SUPFAM; SSF54593; Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase; 1.
DR PROSITE; PS51819; VOC; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000005258}.
FT DOMAIN 4..134
FT /note="VOC"
FT /evidence="ECO:0000259|PROSITE:PS51819"
SQ SEQUENCE 134 AA; 14558 MW; 688B26D0705E3807 CRC64;
MIGRLNHVAI VVPDIEAAAN LYRNTFGATV SAAKDQPAHG VTTVFVRLDN TAIELLHPLG
EDSPVARFLE RNPSGGVHHV CYEVEDIYAA RDKLKADGMR VLGDGEPKIG AHDKPILFLH
PKDTNGTLVE LEQV
//
