ID I3TT71_TISMK Unreviewed; 272 AA.
AC I3TT71;
DT 05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2012, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Transcriptional regulator {ECO:0000313|EMBL:AFK55959.1};
GN Name=iclR {ECO:0000313|EMBL:AFK55959.1};
GN OrderedLocusNames=TMO_a0556 {ECO:0000313|EMBL:AFK55959.1};
OS Tistrella mobilis (strain KA081020-065).
OG Plasmid pTM1 {ECO:0000313|EMBL:AFK55959.1,
OG ECO:0000313|Proteomes:UP000005258}.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Geminicoccales;
OC Geminicoccaceae; Tistrella.
OX NCBI_TaxID=1110502 {ECO:0000313|EMBL:AFK55959.1, ECO:0000313|Proteomes:UP000005258};
RN [1] {ECO:0000313|EMBL:AFK55959.1, ECO:0000313|Proteomes:UP000005258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KA081020-065 {ECO:0000313|Proteomes:UP000005258};
RC PLASMID=Plasmid pTM1 {ECO:0000313|Proteomes:UP000005258};
RX PubMed=22458477; DOI=10.1021/ja301735a;
RA Xu Y., Kersten R.D., Nam S.J., Lu L., Al-Suwailem A.M., Zheng H.,
RA Fenical W., Dorrestein P.C., Moore B.S., Qian P.Y.;
RT "Bacterial biosynthesis and maturation of the didemnin anti-cancer
RT agents.";
RL J. Am. Chem. Soc. 134:8625-8632(2012).
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DR EMBL; CP003237; AFK55959.1; -; Genomic_DNA.
DR RefSeq; WP_014747636.1; NC_017957.2.
DR AlphaFoldDB; I3TT71; -.
DR KEGG; tmo:TMO_a0556; -.
DR PATRIC; fig|1110502.3.peg.4207; -.
DR HOGENOM; CLU_062618_2_0_5; -.
DR Proteomes; UP000005258; Plasmid pTM1.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR014757; Tscrpt_reg_IclR_C.
DR InterPro; IPR005471; Tscrpt_reg_IclR_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR30136; HELIX-TURN-HELIX TRANSCRIPTIONAL REGULATOR, ICLR FAMILY; 1.
DR PANTHER; PTHR30136:SF8; TRANSCRIPTIONAL REGULATORY PROTEIN; 1.
DR Pfam; PF09339; HTH_IclR; 1.
DR Pfam; PF01614; IclR; 1.
DR SMART; SM00346; HTH_ICLR; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
DR PROSITE; PS51077; HTH_ICLR; 1.
DR PROSITE; PS51078; ICLR_ED; 1.
PE 4: Predicted;
KW Plasmid {ECO:0000313|EMBL:AFK55959.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000005258};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 25..87
FT /note="HTH iclR-type"
FT /evidence="ECO:0000259|PROSITE:PS51077"
FT DOMAIN 39..62
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT DOMAIN 88..266
FT /note="IclR-ED"
FT /evidence="ECO:0000259|PROSITE:PS51078"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 272 AA; 28953 MW; 7F8699BD00697115 CRC64;
MEAKQAGARS GGRRGAGGDT KRKGIQSVEI GMGVLDALVR LGRPSSLTDI SRASGQSVSQ
AHRYLASFVN TGFLRQDPAT ALYDLHTGAL RLGLAAMGRL DMFEEASRAA QELVAASGRT
VLIAVWAETG PTIIRWYPGN PPVYTMLTIG SHLSLTQSAT GRIFLAFLNE GFVSDLLQRE
LARDRSEGPV DIDAMRAQTR RELSAAVDGT TAPGLRAFAA PVFNLQGQLV LALSIIASPN
FGRDGDTAAR DMLIAAAREV THRLGGRWPQ PG
//
