ID I3VP76_ONCKI Unreviewed; 327 AA.
AC I3VP76;
DT 05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2012, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Growth/differentiation factor 8 {ECO:0000256|ARBA:ARBA00023852, ECO:0000256|RuleBase:RU369049};
DE Short=GDF-8 {ECO:0000256|RuleBase:RU369049};
DE AltName: Full=Myostatin {ECO:0000256|ARBA:ARBA00031866, ECO:0000256|RuleBase:RU369049};
DE Flags: Fragment;
OS Oncorhynchus kisutch (Coho salmon) (Salmo kisutch).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8019 {ECO:0000313|EMBL:AFK82280.1};
RN [1] {ECO:0000313|EMBL:AFK82280.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23043301; DOI=10.1186/1471-2148-12-202;
RA Lawson C.B., Niino T., Hermansen R.A., Brok-Volchanskaya V., Jackson M.F.,
RA Garikipati D.K., Liberles D.A., Rodgers B.D.;
RT "The salmonid myostatin gene family: a novel model for investigating
RT mechanisms that influence duplicate gene fate.";
RL BMC Evol. Biol. 12:202-202(2012).
CC -!- FUNCTION: Acts specifically as a negative regulator of skeletal muscle
CC growth. {ECO:0000256|RuleBase:RU369049}.
CC -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000256|RuleBase:RU369049}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU369049}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR EMBL; JN990759; AFK82280.1; -; Genomic_DNA.
DR AlphaFoldDB; I3VP76; -.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-UniRule.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF150; GROWTH_DIFFERENTIATION FACTOR 8; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|RuleBase:RU369049};
KW Cytokine {ECO:0000256|ARBA:ARBA00022514, ECO:0000256|RuleBase:RU369049};
KW Disulfide bond {ECO:0000256|RuleBase:RU369049};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU369049};
KW Signal {ECO:0000256|RuleBase:RU369049, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..327
FT /note="Growth/differentiation factor 8"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003681452"
FT DOMAIN 248..327
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT NON_TER 327
FT /evidence="ECO:0000313|EMBL:AFK82280.1"
SQ SEQUENCE 327 AA; 37390 MW; 309BE02104FCEA64 CRC64;
MQFMLYLTLL GVLSTTMGMN ETTRRQANVT EEGEVQQCSN CEFREQSRLM RLHNIRSQIL
SILRLEQAPN ISREMIRQLL PKAPPLTQLI DQYEHRVEDE ERATTETIIT MAKPGPMSQQ
DGIPSCCFFN LSPKIRPNNI LHAQLWVHLR PADTVTTVFL QISRIKATTE GNSRIRILSL
KIDVVSGSSS WQSVDNQLLK TWLHQPETHY GLEIKAYDSK RQDLAVTVAE LGEEGLFMEV
KISENLKRSR RDSALDCDEE SSETLCCRYP LTIDFEAFGW DWIIAPKRFK ANYCSGECEY
MHLQKYPHTH LVNKASAGVP QGPCCTP
//
