ID I4A1E0_ORNRL Unreviewed; 1225 AA.
AC I4A1E0;
DT 05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2012, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Phosphoribosylformylglycinamidine synthase, clade II {ECO:0000313|EMBL:AFL97774.1};
GN OrderedLocusNames=Ornrh_1616 {ECO:0000313|EMBL:AFL97774.1};
OS Ornithobacterium rhinotracheale (strain ATCC 51463 / DSM 15997 / CCUG 23171
OS / CIP 104009 / LMG 9086).
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales; Weeksellaceae;
OC Ornithobacterium.
OX NCBI_TaxID=867902 {ECO:0000313|EMBL:AFL97774.1, ECO:0000313|Proteomes:UP000006051};
RN [1] {ECO:0000313|EMBL:AFL97774.1, ECO:0000313|Proteomes:UP000006051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51463 / DSM 15997 / CCUG 23171 / LMG 9086
RC {ECO:0000313|Proteomes:UP000006051};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Copeland A., Lapidus A., Goodwin L., Pitluck S., Peters L.,
RA Mikhailova N., Teshima H., Kyrpides N., Mavromatis K., Pagani I.,
RA Ivanova N., Ovchinnikova G., Zeytun A., Detter J.C., Han C., Land M.,
RA Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D.,
RA Lang E., Kopitz M., Brambilla E., Klenk H.-P., Eisen J.A.;
RT "The complete genome of Ornithobacterium rhinotracheale DSM 15997.";
RL Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP003283; AFL97774.1; -; Genomic_DNA.
DR RefSeq; WP_014791325.1; NC_018016.1.
DR AlphaFoldDB; I4A1E0; -.
DR STRING; 867902.Ornrh_1616; -.
DR GeneID; 71569693; -.
DR KEGG; orh:Ornrh_1616; -.
DR PATRIC; fig|867902.3.peg.1570; -.
DR eggNOG; COG0046; Bacteria.
DR eggNOG; COG0047; Bacteria.
DR HOGENOM; CLU_003100_2_0_10; -.
DR Proteomes; UP000006051; Chromosome.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004642; F:phosphoribosylformylglycinamidine synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-UniRule.
DR GO; GO:0006164; P:purine nucleotide biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd02203; PurL_repeat1; 1.
DR CDD; cd02204; PurL_repeat2; 1.
DR Gene3D; 3.40.50.880; -; 1.
DR Gene3D; 1.10.8.750; Phosphoribosylformylglycinamidine synthase, linker domain; 1.
DR Gene3D; 3.90.650.10; PurM-like C-terminal domain; 2.
DR Gene3D; 3.30.1330.10; PurM-like, N-terminal domain; 2.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR010141; FGAM_synthase.
DR InterPro; IPR041609; PurL_linker.
DR InterPro; IPR010918; PurM-like_C_dom.
DR InterPro; IPR036676; PurM-like_C_sf.
DR InterPro; IPR036921; PurM-like_N_sf.
DR NCBIfam; TIGR01857; FGAM-synthase; 1.
DR PANTHER; PTHR10099; PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE; 1.
DR PANTHER; PTHR10099:SF1; PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE; 1.
DR Pfam; PF02769; AIRS_C; 1.
DR Pfam; PF18072; FGAR-AT_linker; 1.
DR Pfam; PF13507; GATase_5; 1.
DR SMART; SM01211; GATase_5; 1.
DR SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
DR SUPFAM; SSF56042; PurM C-terminal domain-like; 2.
DR SUPFAM; SSF55326; PurM N-terminal domain-like; 2.
DR PROSITE; PS51273; GATASE_TYPE_1; 1.
PE 4: Predicted;
KW Glutamine amidotransferase {ECO:0000256|PROSITE-ProRule:PRU00605};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Purine biosynthesis {ECO:0000256|ARBA:ARBA00022755};
KW Reference proteome {ECO:0000313|Proteomes:UP000006051}.
FT DOMAIN 172..220
FT /note="Phosphoribosylformylglycinamidine synthase linker"
FT /evidence="ECO:0000259|Pfam:PF18072"
FT DOMAIN 430..583
FT /note="PurM-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02769"
FT ACT_SITE 1067
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
FT ACT_SITE 1196
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
FT ACT_SITE 1198
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
SQ SEQUENCE 1225 AA; 135561 MW; B20A4CA83FD43CA9 CRC64;
MNQRIFIEKK AAFDHLSKSF TEELHLINPA LSVKVFILYD LFNISEEDFK KVSHTVFADP
VMDILHTSEP DLSAYQKTVA VEFLPGQFDQ RADSAEQAVK LITGKDDIKI RTAKLFAFPE
ISDKEFAEAK KLFINVVDAK EKDLSVLNYP QSAQPHPVPV IEGFIDFDDA QLEKFYQEWS
FAFGLDDLKF IQDYFKKENR NPTETELKVL DTYWSDHCRH TTFMTELENI SFEGDFQETL
QAIYDRYLAL RKELNREHKP ISLMDFGTIA AKYFQKNGKL NDLVISDEIN ACTIEIEVDV
EGKKEPWYLL FKNETHNHPT EIEPFGGAST CIGGAIRDPL SGRAFVYQAM RVTGAANPLE
NVEDTLEGKL PQRKITKEAA NGYSSYGNQI GLATSQVSEI YHEGYKAKRM EVGFVVGAAP
TDWVKREQPQ AGDVVIVLGG KTGRDGVGGA TGSSKTQKVG AIETMSAEVQ KGDAVQERKI
QRLFRKPEVT TLIKKSNDFG AGGVSVAIGE IADGVYIDLD VLPVKYDGLY GTELAISESQ
ERMAVVVDAA DAPKFLELAR AENILAEIVG TVTDKNRLEI VWKGDKIVDL DREFLDTAGC
RKKNNAKVSL NALKAKETKS LNKENFVQTL QSLNVASQKG LIEKFDSTVG QTTVLMPLGG
KYQVTPALAS VHTLPVRNKN TSTVSMASWG YDVDLSSENP LLGGAYAVVE SVAKIVAAGG
KREDVRLSFQ EYFERLGTDE NKWGIPLASL MGSLDAQLNF EIAAIGGKDS MSGTFHDLKV
PPTLISFACC AGELKNVISP EFKAEGNHLY LFKHEPLENG MPNYEQLKSA YAQIHQLIEK
GEIVSAQIVK NGGLASALAL MAFGNKLGAS VQFEGDWFSP MHGSLILESK TELNDFQKIG
SISAEKSLVL NHETFDLDEL FNAWFGTFES LFPTDFGKDL QNAEKSEVTK DKTKNVNINS
GAKPQVAMPI FSGTNCEYET EKVFREAGAN PQPFIFNNLN DALLNDSVEH MVKTINESQI
LMLSGGFSSG DEPDGSAKFI VSVLKNPKIK QAVHDLIARD GLILGICNGF QALIKSGLVS
FGEICDLPED APTLAHNKIG RHISQMVDVR VVSDRSPWLK GMKNQIYRIP ISHGEGRFFA
NPEVVQQLKD KDQIATQYVD LNGNVAFDMP FNPNSSVDGI EGIMSPSGKI FGRMGHPERY
RNGLLKNIPD AVFMDIFKNG VEYFK
//
