ID   I4CAE8_DESTA            Unreviewed;       644 AA.
AC   I4CAE8;
DT   05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT   05-SEP-2012, sequence version 1.
DT   27-MAR-2024, entry version 51.
DE   SubName: Full=HAMP domain-containing protein,cache domain-containing protein {ECO:0000313|EMBL:AFM26539.1};
GN   OrderedLocusNames=Desti_3897 {ECO:0000313|EMBL:AFM26539.1};
OS   Desulfomonile tiedjei (strain ATCC 49306 / DSM 6799 / DCB-1).
OC   Bacteria; Thermodesulfobacteriota; Desulfomonilia; Desulfomonilales;
OC   Desulfomonilaceae; Desulfomonile.
OX   NCBI_TaxID=706587 {ECO:0000313|EMBL:AFM26539.1, ECO:0000313|Proteomes:UP000006055};
RN   [1] {ECO:0000313|Proteomes:UP000006055}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49306 / DSM 6799 / DCB-1
RC   {ECO:0000313|Proteomes:UP000006055};
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Peters L., Ovchinnikova G., Zeytun A.,
RA   Lu M., Kyrpides N., Mavromatis K., Ivanova N., Brettin T., Detter J.C.,
RA   Han C., Larimer F., Land M., Hauser L., Markowitz V., Cheng J.-F.,
RA   Hugenholtz P., Woyke T., Wu D., Spring S., Schroeder M., Brambilla E.,
RA   Klenk H.-P., Eisen J.A.;
RT   "Complete sequence of chromosome of Desulfomonile tiedjei DSM 6799.";
RL   Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; CP003360; AFM26539.1; -; Genomic_DNA.
DR   RefSeq; WP_014811665.1; NC_018025.1.
DR   AlphaFoldDB; I4CAE8; -.
DR   STRING; 706587.Desti_3897; -.
DR   KEGG; dti:Desti_3897; -.
DR   PATRIC; fig|706587.4.peg.4422; -.
DR   eggNOG; COG2208; Bacteria.
DR   eggNOG; COG2770; Bacteria.
DR   HOGENOM; CLU_020306_0_0_7; -.
DR   OrthoDB; 9802500at2; -.
DR   Proteomes; UP000006055; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd06225; HAMP; 1.
DR   CDD; cd12913; PDC1_MCP_like; 1.
DR   CDD; cd12912; PDC2_MCP_like; 1.
DR   Gene3D; 6.10.340.10; -; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 2.
DR   Gene3D; 3.60.40.10; PPM-type phosphatase domain; 1.
DR   InterPro; IPR033479; dCache_1.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR036457; PPM-type-like_dom_sf.
DR   InterPro; IPR001932; PPM-type_phosphatase-like_dom.
DR   PANTHER; PTHR43156; STAGE II SPORULATION PROTEIN E-RELATED; 1.
DR   Pfam; PF02743; dCache_1; 1.
DR   Pfam; PF00672; HAMP; 1.
DR   Pfam; PF07228; SpoIIE; 1.
DR   SMART; SM00304; HAMP; 1.
DR   SMART; SM00331; PP2C_SIG; 1.
DR   SUPFAM; SSF158472; HAMP domain-like; 1.
DR   SUPFAM; SSF81606; PP2C-like; 1.
DR   PROSITE; PS50885; HAMP; 1.
DR   PROSITE; PS51746; PPM_2; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006055};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        316..334
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          335..388
FT                   /note="HAMP"
FT                   /evidence="ECO:0000259|PROSITE:PS50885"
FT   DOMAIN          424..639
FT                   /note="PPM-type phosphatase"
FT                   /evidence="ECO:0000259|PROSITE:PS51746"
SQ   SEQUENCE   644 AA;  70267 MW;  5DFE011B857516B7 CRC64;
     MKTRWFYSLA TKTTVLVALG TSLVLAAVLT YGYRSSRDII EYQAGQSLLN LAKSTAVRME
     LELRSVAEVA GNLAAVLETD RLDAVTLDAL IRRNVQDHPA VFGSAVAFEP FSFVSGVKAY
     APYFFQQQNG ISFIDLATES YDYFHRDWYS VPREIGKPMW SPPYFDEGGG NVVMTTYSQP
     FFRPHSSAER QIWGIVTADV SVEWLTKELS TVQAGKTGYC FLISETGVFL AHPEKNFIMQ
     ESVFSLAEEN NLPGLRETGK RMLSSDSGFI DMGESIDKKQ LFLGFARLPS TGWSLGVIYP
     RDELFSEISM LYRTNVMLAV AGLFALLAVS VLLARSVTSP LRKIAEAASR VAAGDLNYDL
     PATHGRDEVG ELARAFKNMT VDLKKYIQDL TVTTAAKERI ESELGVAASI QKSMLPSKFP
     DREDFDIYAV MDPAKEVGGD FYQFLLVDSD RLFVAIGDVS GKGVPAALLM TVATSLIRSA
     AAEGQAPHSV LEHLNNHLVP GNDSCMFVTV FCGMLDLKTG ALTYANGGHE RPLIVRADGH
     IASLSPPGGP VLGIMDGMEF AEEQIVLEPG DCLISFTDGV TEAMNTNDEL YSRDRLISCL
     DGSKGVTAHF VTAKVLDSVS TFATGAPQAD DITVLAVKFN GRRH
//