ID I4EQR3_9ACTN Unreviewed; 568 AA.
AC I4EQR3;
DT 05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2012, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE SubName: Full=FAD linked oxidase {ECO:0000313|EMBL:CCH85726.1};
GN OrderedLocusNames=MODMU_0264 {ECO:0000313|EMBL:CCH85726.1};
OS Modestobacter marinus.
OC Bacteria; Actinomycetota; Actinomycetes; Geodermatophilales;
OC Geodermatophilaceae; Modestobacter.
OX NCBI_TaxID=477641 {ECO:0000313|EMBL:CCH85726.1, ECO:0000313|Proteomes:UP000006461};
RN [1] {ECO:0000313|EMBL:CCH85726.1, ECO:0000313|Proteomes:UP000006461}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BC501 {ECO:0000313|EMBL:CCH85726.1,
RC ECO:0000313|Proteomes:UP000006461};
RX PubMed=22887672; DOI=10.1128/JB.01029-12;
RA Normand P., Gury J., Pujic P., Chouaia B., Crotti E., Brusetti L.,
RA Daffonchio D., Vacherie B., Barbe V., Medigue C., Calteau A.,
RA Ghodhbane-Gtari F., Essoussi I., Nouioui I., Abbassi-Ghozzi I., Gtari M.;
RT "Genome Sequence of Radiation-Resistant Modestobacter marinus Strain BC501,
RT a Representative Actinobacterium That Thrives on Calcareous Stone
RT Surfaces.";
RL J. Bacteriol. 194:4773-4774(2012).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|PIRSR:PIRSR625650-3};
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DR EMBL; FO203431; CCH85726.1; -; Genomic_DNA.
DR RefSeq; WP_014738342.1; NC_017955.1.
DR AlphaFoldDB; I4EQR3; -.
DR STRING; 477641.MODMU_0264; -.
DR KEGG; mmar:MODMU_0264; -.
DR PATRIC; fig|477641.3.peg.252; -.
DR eggNOG; COG0277; Bacteria.
DR HOGENOM; CLU_017779_2_0_11; -.
DR OMA; GTISHQH; -.
DR OrthoDB; 9811557at2; -.
DR Proteomes; UP000006461; Chromosome.
DR GO; GO:0005777; C:peroxisome; IEA:UniProt.
DR GO; GO:0008609; F:alkylglycerone-phosphate synthase activity; IEA:InterPro.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.30.300.330; -; 1.
DR Gene3D; 3.30.465.10; -; 1.
DR Gene3D; 3.30.70.3450; -; 1.
DR InterPro; IPR025650; Alkyl-DHAP_Synthase.
DR InterPro; IPR004113; FAD-bd_oxidored_4_C.
DR InterPro; IPR016166; FAD-bd_PCMH.
DR InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR InterPro; IPR016164; FAD-linked_Oxase-like_C.
DR InterPro; IPR006094; Oxid_FAD_bind_N.
DR InterPro; IPR016171; Vanillyl_alc_oxidase_C-sub2.
DR PANTHER; PTHR46568; ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE, PEROXISOMAL; 1.
DR PANTHER; PTHR46568:SF1; ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE, PEROXISOMAL; 1.
DR Pfam; PF02913; FAD-oxidase_C; 1.
DR Pfam; PF01565; FAD_binding_4; 1.
DR SUPFAM; SSF56176; FAD-binding/transporter-associated domain-like; 1.
DR SUPFAM; SSF55103; FAD-linked oxidases, C-terminal domain; 1.
DR PROSITE; PS51387; FAD_PCMH; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|PIRSR:PIRSR625650-3};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR625650-3};
KW Reference proteome {ECO:0000313|Proteomes:UP000006461}.
FT DOMAIN 124..305
FT /note="FAD-binding PCMH-type"
FT /evidence="ECO:0000259|PROSITE:PS51387"
FT ACT_SITE 487
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR625650-1"
FT BINDING 156..162
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR625650-3"
FT BINDING 289..295
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR625650-3"
FT BINDING 426
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR625650-2"
FT SITE 340
FT /note="Important for enzyme activity"
FT /evidence="ECO:0000256|PIRSR:PIRSR625650-4"
SQ SEQUENCE 568 AA; 59540 MW; 8AFC037254435344 CRC64;
MADLPELTVQ GWGPSGDRVA TVAAREGATA PDDGVLELAP DSGDGLPRAA RALLARELGW
TPRPTPPVPV RDIRLAPSRL PADARARFVA LLGEDAVLDD RHARLGHAGG KSYLDLLRRR
GGDASDAPDA VLLPDGTEQV AALLRTCGEL GVVVVPFGGG TSVVGGLAGT DADDRPVVAV
DLRRMAGVRG LDVPSALVTV GPGMRGPALE EALAADGLTL GHLPQSWEFA TLGGYAATRS
AGQSSTGVGR FDDLVAGLTL ATPSGVLELG NPPASAAGPD LLGLALGSEG TLGVITELRL
RVRPRPRSSQ YEGWSFRSWA AGLAALQRLA RHDLLPDVVR LSDPDETRVS LRQSGGLGAR
VLRGTLRARR RGAGCLLVVG WEGLPTIVRA RRSAASSVLR DGGAVRLGSR VGRSWVRHRF
AAPYLRDRLL DNGLLVETLE TAATWSALPG VYDAVRRALR GALTGPGRRP LVMTHVSHGY
PTGASLYLTV LADRDDDLPI QQWLTAKRAA TDALLAAGGT LTHHHGVGAD HRPWLAQEIG
PLGVDVLRSV KQRLDPQGIC NPGVLLPD
//
