ID   I4EVU7_9ACTN            Unreviewed;       489 AA.
AC   I4EVU7;
DT   05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT   05-SEP-2012, sequence version 1.
DT   27-MAR-2024, entry version 49.
DE   RecName: Full=DNA ligase (ATP) {ECO:0000256|ARBA:ARBA00012727};
DE            EC=6.5.1.1 {ECO:0000256|ARBA:ARBA00012727};
GN   OrderedLocusNames=MODMU_2075 {ECO:0000313|EMBL:CCH87510.1};
OS   Modestobacter marinus.
OC   Bacteria; Actinomycetota; Actinomycetes; Geodermatophilales;
OC   Geodermatophilaceae; Modestobacter.
OX   NCBI_TaxID=477641 {ECO:0000313|EMBL:CCH87510.1, ECO:0000313|Proteomes:UP000006461};
RN   [1] {ECO:0000313|EMBL:CCH87510.1, ECO:0000313|Proteomes:UP000006461}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BC501 {ECO:0000313|EMBL:CCH87510.1,
RC   ECO:0000313|Proteomes:UP000006461};
RX   PubMed=22887672; DOI=10.1128/JB.01029-12;
RA   Normand P., Gury J., Pujic P., Chouaia B., Crotti E., Brusetti L.,
RA   Daffonchio D., Vacherie B., Barbe V., Medigue C., Calteau A.,
RA   Ghodhbane-Gtari F., Essoussi I., Nouioui I., Abbassi-Ghozzi I., Gtari M.;
RT   "Genome Sequence of Radiation-Resistant Modestobacter marinus Strain BC501,
RT   a Representative Actinobacterium That Thrives on Calcareous Stone
RT   Surfaces.";
RL   J. Bacteriol. 194:4773-4774(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-
CC         (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP +
CC         diphosphate.; EC=6.5.1.1; Evidence={ECO:0000256|ARBA:ARBA00034003};
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DR   EMBL; FO203431; CCH87510.1; -; Genomic_DNA.
DR   RefSeq; WP_014740105.1; NC_017955.1.
DR   AlphaFoldDB; I4EVU7; -.
DR   STRING; 477641.MODMU_2075; -.
DR   KEGG; mmar:MODMU_2075; -.
DR   PATRIC; fig|477641.3.peg.1967; -.
DR   eggNOG; COG1793; Bacteria.
DR   HOGENOM; CLU_008325_2_0_11; -.
DR   OMA; QWLAHRM; -.
DR   OrthoDB; 9802472at2; -.
DR   Proteomes; UP000006461; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR   CDD; cd07906; Adenylation_DNA_ligase_LigD_LigC; 1.
DR   CDD; cd07971; OBF_DNA_ligase_LigD; 1.
DR   Gene3D; 3.30.1490.70; -; 1.
DR   Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR   InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR014146; LigD_ligase_dom.
DR   InterPro; IPR014144; LigD_PE_domain.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   NCBIfam; TIGR02779; NHEJ_ligase_lig; 1.
DR   PANTHER; PTHR45674:SF15; DNA LIGASE (ATP); 1.
DR   PANTHER; PTHR45674; DNA LIGASE 1/3 FAMILY MEMBER; 1.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF13298; LigD_N; 1.
DR   SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   4: Predicted;
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:CCH87510.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006461}.
FT   DOMAIN          281..399
FT                   /note="ATP-dependent DNA ligase family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50160"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   489 AA;  53431 MW;  94DF9B804D3AF243 CRC64;
     MAPPDPLATY RAKRDPARTA EPVPAADQPL PVGDDDTFVV QEHHTPRGRT GQRVHWDLRL
     ERDGVLKSWA VPKGPPTEPG VNRLAVPTED HPLEYASFAG TITAGEYGGG QVSIWDAGRY
     ATEKWADDHV TVSFDGRRLS GRYVVFRLPD GTWNVRKLDA DPVVDAPVAA GVPEDLTPML
     AAIGELPRAD DPRWGYEFKW DGVRALAHVR GGRVRLRARS GNDVTATYPE LHRLPEVLSG
     HDAVVDGEVV ALDGRGRPDF GLLQGRMHRT GPEVARMAAA APVTYLVFDL LALDGENLLG
     LPYTERRERL DALGLASDRW VTTPWFRGNG EQVQAASLEN GLEGVVAKRL DSVYRPGGRG
     PDWRKVKNLR TQSVVVGGWR PGEGRRAGGI GSLLVGVHDD TGRLVFAGHV GTGFTARALA
     DLAPLLTPRA TPPFADALPR EVTRDARWVE PLLVGEVRYG EWTREGRLRH PAWRGLRDDV
     AAADVVVEP
//