ID I4FVW9_MICAE Unreviewed; 348 AA.
AC I4FVW9;
DT 05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2012, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE RecName: Full=Glucokinase {ECO:0000256|HAMAP-Rule:MF_00524};
DE EC=2.7.1.2 {ECO:0000256|HAMAP-Rule:MF_00524};
DE AltName: Full=Glucose kinase {ECO:0000256|HAMAP-Rule:MF_00524};
GN Name=glk {ECO:0000256|HAMAP-Rule:MF_00524,
GN ECO:0000313|EMBL:CCH99794.1};
GN ORFNames=MICAB_6780009 {ECO:0000313|EMBL:CCH99794.1};
OS Microcystis aeruginosa PCC 9717.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
OC Chroococcales; Microcystaceae; Microcystis.
OX NCBI_TaxID=1160286 {ECO:0000313|EMBL:CCH99794.1, ECO:0000313|Proteomes:UP000003172};
RN [1] {ECO:0000313|EMBL:CCH99794.1, ECO:0000313|Proteomes:UP000003172}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=9717 {ECO:0000313|EMBL:CCH99794.1,
RC ECO:0000313|Proteomes:UP000003172};
RA Genoscope - CEA;
RL Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+);
CC Xref=Rhea:RHEA:17825, ChEBI:CHEBI:4167, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61548, ChEBI:CHEBI:456216; EC=2.7.1.2;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_00524};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00524}.
CC -!- SIMILARITY: Belongs to the bacterial glucokinase family.
CC {ECO:0000256|HAMAP-Rule:MF_00524, ECO:0000256|RuleBase:RU004046}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCH99794.1}.
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DR EMBL; CAII01000643; CCH99794.1; -; Genomic_DNA.
DR RefSeq; WP_004266785.1; NZ_HE972764.1.
DR AlphaFoldDB; I4FVW9; -.
DR HOGENOM; CLU_042582_0_0_3; -.
DR Proteomes; UP000003172; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004340; F:glucokinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.420.40; -; 1.
DR Gene3D; 3.40.367.20; -; 1.
DR HAMAP; MF_00524; Glucokinase; 1.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR003836; Glucokinase.
DR NCBIfam; TIGR00749; glk; 1.
DR PANTHER; PTHR47363; GLUCOKINASE; 1.
DR PANTHER; PTHR47363:SF1; GLUCOKINASE; 1.
DR Pfam; PF02685; Glucokinase; 1.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|HAMAP-Rule:MF_00524};
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00524};
KW Glycolysis {ECO:0000256|HAMAP-Rule:MF_00524};
KW Kinase {ECO:0000256|HAMAP-Rule:MF_00524, ECO:0000313|EMBL:CCH99794.1};
KW Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00524};
KW Transferase {ECO:0000256|HAMAP-Rule:MF_00524, ECO:0000313|EMBL:CCH99794.1}.
FT BINDING 7..12
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00524"
SQ SEQUENCE 348 AA; 37700 MW; AFF0B405C73DBD31 CRC64;
MTILLGGDIG GTKTILRLVD CQNSSDSPQP RLITLDQEIY PSEQYPDLVP IVRQFLARQT
TIPPVAKACF GIAGPVVNNS SELTNLSWSL TGDRLSQELQ IERVKLINDF AAIGYGVLGL
APEELHNLQS APAVPEAPIA VIGAGTGLGE GFLIPVSKGK YQVFASEGSH ADFAPRSSLE
YQLLNYLLEL YNIERISVER VVSGPGITSI YRFLHDSNYS QSSPAMAEIY RAWLEEMGKP
QKTVDLAAKI ASFAQDNSDH LCYQTMKIFV EAYGAEAGNL ALKLLPYGGL YIAGGIAAKN
LPLMTEGSFM KAFRAKGRMT EILSNIPVHI VLNTQVGLMG AVYCASQL
//
