ID   I6CIJ1_SHIFL            Unreviewed;       300 AA.
AC   I6CIJ1;
DT   05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT   05-SEP-2012, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   SubName: Full=Efflux pump membrane family protein {ECO:0000313|EMBL:EIQ19333.1};
GN   ORFNames=SFK315_2813 {ECO:0000313|EMBL:EIQ19333.1};
OS   Shigella flexneri K-315.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=766150 {ECO:0000313|EMBL:EIQ19333.1, ECO:0000313|Proteomes:UP000005407};
RN   [1] {ECO:0000313|EMBL:EIQ19333.1, ECO:0000313|Proteomes:UP000005407}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K-315 {ECO:0000313|EMBL:EIQ19333.1,
RC   ECO:0000313|Proteomes:UP000005407};
RA   Rasko D., Redman J., Daugherty S.C., Tallon L., Sadzewicz L., Jones K.,
RA   Santana-Cruz I., Liu X.;
RL   Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC       family. {ECO:0000256|ARBA:ARBA00009477}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EIQ19333.1}.
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DR   EMBL; AKMY01000057; EIQ19333.1; -; Genomic_DNA.
DR   AlphaFoldDB; I6CIJ1; -.
DR   Proteomes; UP000005407; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR   Gene3D; 2.40.30.170; -; 1.
DR   Gene3D; 2.40.50.100; -; 1.
DR   Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR   InterPro; IPR043602; CusB_dom_1.
DR   InterPro; IPR032317; HlyD_D23.
DR   InterPro; IPR005694; MFP_proteobact.
DR   NCBIfam; TIGR00998; 8a0101; 1.
DR   PANTHER; PTHR30386; MEMBRANE FUSION SUBUNIT OF EMRAB-TOLC MULTIDRUG EFFLUX PUMP; 1.
DR   PANTHER; PTHR30386:SF19; MULTIDRUG EXPORT PROTEIN EMRA-RELATED; 1.
DR   Pfam; PF00529; CusB_dom_1; 1.
DR   Pfam; PF16576; HlyD_D23; 1.
DR   SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022519};
KW   Membrane {ECO:0000256|ARBA:ARBA00022989};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   DOMAIN          21..249
FT                   /note="RND efflux pump membrane fusion protein barrel-
FT                   sandwich"
FT                   /evidence="ECO:0000259|Pfam:PF16576"
FT   DOMAIN          250..299
FT                   /note="Cation efflux system protein CusB"
FT                   /evidence="ECO:0000259|Pfam:PF00529"
SQ   SEQUENCE   300 AA;  32848 MW;  FEDDE6ACE826F794 CRC64;
     MELEDMISTD DAYVTGNADP ISAQVSGSVT VVNHKDTNYV RQGDILVSLD KTDATIALNK
     AKNNLANIVR QTNKLYLQDK QYSAEVASAR IQYQQSLEDY NRRVPLAKQG VISKETLEHT
     KDTLISSKAA LNAAIQAYKA NKALVMNTPL NRQPQVVEAA DATKEAWLAL KRTDIKSPVT
     GYIAQRSVQV GETVSPGQSL MAVVPARQMW VNANFKETQL TDVRIGQSVN IISDLYGENV
     VFHGRVTGIN MGTGNAFSLL PAQNATGNWI KIVQRVPVEV SLDPKELMEH PLRIGLSMTG
//