ID I6M3D6_9HIV1 Unreviewed; 698 AA.
AC I6M3D6;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Envelope glycoprotein gp160 {ECO:0000256|ARBA:ARBA00015406};
DE AltName: Full=Env polyprotein {ECO:0000256|ARBA:ARBA00029888};
DE Flags: Fragment;
GN Name=env {ECO:0000313|EMBL:AEI55608.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:AEI55608.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:AEI55608.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=1689_I_24 {ECO:0000313|EMBL:AEI55608.1};
RX PubMed=23824043;
RA Jakobsen M.R., Cashin K., Roche M., Sterjovski J., Ellett A., Borm K.,
RA Flynn J., Erikstrup C., Gouillou M., Gray L.R., Saksena N.K., Wang B.,
RA Purcell D.F., Kallestrup P., Zinyama-Gutsire R., Gomo E., Ullum H.,
RA Ostergaard L., Lee B., Ramsland P.A., Churchill M.J., Gorry P.R.;
RT "Longitudinal Analysis of CCR5 and CXCR4 Usage in a Cohort of
RT Antiretroviral Therapy-Naive Subjects with Progressive HIV-1 Subtype C
RT Infection.";
RL PLoS ONE 8:E65950-E65950(2013).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell
CC membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004251}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004530}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004530}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004505}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004505}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004402}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004433}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004433}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004578}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004578}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004650}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004650}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004563}.
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DR EMBL; HQ707985; AEI55608.1; -; Genomic_DNA.
DR GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR CDD; cd09909; HIV-1-like_HR1-HR2; 1.
DR Gene3D; 1.10.287.210; -; 1.
DR Gene3D; 2.170.40.20; Human immunodeficiency virus 1, Gp160, envelope glycoprotein; 2.
DR Gene3D; 1.20.5.490; Single helix bin; 1.
DR InterPro; IPR036377; Gp120_core_sf.
DR InterPro; IPR000328; GP41-like.
DR InterPro; IPR000777; HIV1_Gp120.
DR Pfam; PF00516; GP120; 1.
DR Pfam; PF00517; GP41; 1.
DR SUPFAM; SSF56502; gp120 core; 2.
DR SUPFAM; SSF58069; Virus ectodomain; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW Host endosome {ECO:0000256|ARBA:ARBA00023046};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Viral envelope protein {ECO:0000313|EMBL:AEI55608.1};
KW Virion {ECO:0000313|EMBL:AEI55608.1}.
FT TRANSMEM 627..654
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..460
FT /note="Human immunodeficiency virus 1 envelope glycoprotein
FT Gp120"
FT /evidence="ECO:0000259|Pfam:PF00516"
FT DOMAIN 479..670
FT /note="Retroviral envelope protein GP41-like"
FT /evidence="ECO:0000259|Pfam:PF00517"
FT REGION 672..698
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 676..690
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AEI55608.1"
FT NON_TER 698
FT /evidence="ECO:0000313|EMBL:AEI55608.1"
SQ SEQUENCE 698 AA; 78263 MW; 973BB88C436415A2 CRC64;
AKATLFCASD AKAYEKEVHN IWATHACVPT DPNPQEMFLK NVTENFNIWK NDMVEQMHED
IISLWDQSLK PCVKLTPLCV TLNCSNANVN ITKIDGTTLN NTREGEIKNC SFNTTTEIRD
KKQQAYALFY KPDVMPLSGK SDGKEYILIN CNNSVITQAC PKVSFDPIPI HYCAPAGYAI
LKCNDKTFNG TGPCDDVSTV QCTHGIKPVV STQLLLNGSL AEGEVIIKAE NLTRSANTII
VHLNESVEIV CTRPNNNTRK SVRIGPGQEF YATGAIIGNI RQAHCNIRED KWNKTLQKVG
KKLKEYFPDK TIEFAPSSGG DLEIATHMFN CGGEFFYCNT SGLFNGTYVP NITDSTSNKT
IILQCRIKQI INMWQGVGRA MYAPPIAGNI TCKSNITGLL LTRDGGDNTS RNDTEIFRPG
GGNMKDNRRN ELYKYKVVEI KPLGIAPTEA KRRVVEREKR AVGIGAVFLG FLGAAGSTMG
AASITLTVQA RQLLSGIVQQ QSNLLRAIEA QQHMLQLTVW GIKQLQARVL AIERYLKDQQ
LLGIWGCSGK LICTTNVPWN SSWSNKSLDD IWENMTWMQW DKEISNYSDT IYRLLEESQN
QQERNEKDLL ALDSWKNLWS WFDISNWLWY IKIFIMIVGG LIGLRIIFAV LSIVNRVRQG
YSPLSFQTLT PNSREPDRLG RIEEGGGEQD SNRSIRLV
//
