ID I6M3P7_9HIV1 Unreviewed; 698 AA.
AC I6M3P7;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Envelope glycoprotein gp160 {ECO:0000256|ARBA:ARBA00015406};
DE AltName: Full=Env polyprotein {ECO:0000256|ARBA:ARBA00029888};
DE Flags: Fragment;
GN Name=env {ECO:0000313|EMBL:AEI55719.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:AEI55719.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:AEI55719.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=550_E_20 {ECO:0000313|EMBL:AEI55719.1};
RX PubMed=23824043;
RA Jakobsen M.R., Cashin K., Roche M., Sterjovski J., Ellett A., Borm K.,
RA Flynn J., Erikstrup C., Gouillou M., Gray L.R., Saksena N.K., Wang B.,
RA Purcell D.F., Kallestrup P., Zinyama-Gutsire R., Gomo E., Ullum H.,
RA Ostergaard L., Lee B., Ramsland P.A., Churchill M.J., Gorry P.R.;
RT "Longitudinal Analysis of CCR5 and CXCR4 Usage in a Cohort of
RT Antiretroviral Therapy-Naive Subjects with Progressive HIV-1 Subtype C
RT Infection.";
RL PLoS ONE 8:E65950-E65950(2013).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell
CC membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004251}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004530}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004530}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004505}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004505}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004402}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004433}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004433}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004578}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004578}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004650}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004650}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004563}.
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DR EMBL; HQ708096; AEI55719.1; -; Genomic_DNA.
DR GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR CDD; cd09909; HIV-1-like_HR1-HR2; 1.
DR Gene3D; 1.10.287.210; -; 1.
DR Gene3D; 2.170.40.20; Human immunodeficiency virus 1, Gp160, envelope glycoprotein; 2.
DR Gene3D; 1.20.5.490; Single helix bin; 1.
DR InterPro; IPR036377; Gp120_core_sf.
DR InterPro; IPR000328; GP41-like.
DR InterPro; IPR000777; HIV1_Gp120.
DR Pfam; PF00516; GP120; 1.
DR Pfam; PF00517; GP41; 1.
DR SUPFAM; SSF56502; gp120 core; 2.
DR SUPFAM; SSF58069; Virus ectodomain; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW Host endosome {ECO:0000256|ARBA:ARBA00023046};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Viral envelope protein {ECO:0000313|EMBL:AEI55719.1};
KW Virion {ECO:0000313|EMBL:AEI55719.1}.
FT TRANSMEM 627..654
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..460
FT /note="Human immunodeficiency virus 1 envelope glycoprotein
FT Gp120"
FT /evidence="ECO:0000259|Pfam:PF00516"
FT DOMAIN 479..669
FT /note="Retroviral envelope protein GP41-like"
FT /evidence="ECO:0000259|Pfam:PF00517"
FT REGION 668..698
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 676..698
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AEI55719.1"
FT NON_TER 698
FT /evidence="ECO:0000313|EMBL:AEI55719.1"
SQ SEQUENCE 698 AA; 78566 MW; 9C5AA5865DB7570B CRC64;
AKTTLFCASD AKAYEKEAHN VWATHACAPT DPYPQEVVLE NVTENFNMWK NDMVDQMHED
IISLWDQSLK PCVMLTPLCV TLNCTNANVT YSNSNKNSSI EELKNELKNC SFNTTTDLRD
KRKKEYALFY RLDIVSLANA SGEYRLINCN TSTVTQACPK VSFDPIPIHY CAPAGYAILK
CNNKTFNGTG PCTNVSTVQC THGIKPVVST QLLINGSLAE EEIIIRSKNL TDNAKTIIVH
LNNSVNIVCT RPNNNTRKSI SLGPGQAFYA TGDIIGDIRQ AHCNISESKW KETLLNVSKK
LKEHFPQASD ISFQPPAGGD LEITTHSFNC GGEFFYCNTS GLFNYTYNST HWNNTNSNTS
NSTITLPCRI KQIINMWQKV GRAMYTPPIA GNITCNSSIT GILLTRDGGA NNTNETFRPT
GGDMKDNWRS ELYKYKVVEI KPLGIAPTKA KRRVVEGEKR AVGLGAVFLG FLGAAGSTMG
AASLTLTVQA RQLLSGIVQQ QNDLLRAIEA QQHMLQLTVW GIKQLQARVL ALERYLRDQQ
LLGIWGCSGK LICTTSVPWN SSWSNKTLDD IWGNMTWMEW DREIDNYTRT IYRLLEESQN
QQEKNEQELL ELDSWANLWN WFDISKWLWY IRIFIMIIGG LIGLRIIFAV LSIVKRVRQG
YSPLSFQTLT PSPRGPDRLE RIEEEGGEQD RDRSIRLV
//
