ID   I6M4A6_KRYMA            Unreviewed;       545 AA.
AC   I6M4A6;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   22-FEB-2023, entry version 33.
DE   SubName: Full=MSH2 {ECO:0000313|EMBL:AEI73154.1};
DE   Flags: Fragment;
OS   Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX   NCBI_TaxID=37003 {ECO:0000313|EMBL:AEI73154.1};
RN   [1] {ECO:0000313|EMBL:AEI73154.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Rhee J.-S., Lee J.-S.;
RL   Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; HM591217; AEI73154.1; -; mRNA.
DR   AlphaFoldDB; I6M4A6; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR   Gene3D; 1.10.1420.10; -; 2.
DR   Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR   InterPro; IPR011184; DNA_mismatch_repair_Msh2.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   PANTHER; PTHR11361:SF35; DNA MISMATCH REPAIR PROTEIN MSH2; 1.
DR   PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   PIRSF; PIRSF005813; MSH2; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR   SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840}.
FT   DOMAIN          212..536
FT                   /note="DNA mismatch repair protein MutS core"
FT                   /evidence="ECO:0000259|SMART:SM00533"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AEI73154.1"
FT   NON_TER         545
FT                   /evidence="ECO:0000313|EMBL:AEI73154.1"
SQ   SEQUENCE   545 AA;  60511 MW;  FE129695AD05EA1A CRC64;
     SKEHDWRIDY KASPGNLTQF EEILFGGGTG AEVCAGVVAV RLATGADGQR VVGVGYVDAA
     QRKMGVCEFP DSEIFSNLES LLVQIGPKEC LLAQGESGAD GNKLREVVQR GGMLVSDRKK
     AEFNSKDIVQ DLNRLLLSKR GETAASNTLP ELDKQVAMSC LAAVVRFLEL LSDESNFNSF
     SLTTLQLGQY MRLDHAAVRA LNLFQGSPDD TSGAHSLAGL LNKCRTPQGQ RLVNQWIKQP
     LMDKTKIEER LDLVDGFVCD SELRQTCQED LLRRFPDLHR LAKKFHRHTA TLQDCYRVHQ
     AVSQLPGLVA ALDRYSGSYQ VLLQAVFTSP LRDLQTDFTK YQEMIETTLD MNQIEHHEFL
     VKASFDPVLS ELREKMDALE KSMQAALSSA ARELGLEAGK TVKLESNAVL GFYLRVTCKE
     EKSLRNNKKF TTLDVQKNGV RFTNSKLSSL NEEYTKSREE YEEAQNAIVK EIINIASGYV
     DPLQALNDVV AQLDAVASFA VAAVSAPVPY VRPRILDGGC RRLELLQARH PCMETDADTA
     FIPND
//