ID   I6NWZ7_9ANUR            Unreviewed;       235 AA.
AC   I6NWZ7;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   RecName: Full=Brain-derived neurotrophic factor {ECO:0000256|ARBA:ARBA00022282, ECO:0000256|RuleBase:RU364086};
DE            Short=BDNF {ECO:0000256|RuleBase:RU364086};
DE   Flags: Fragment;
GN   Name=bdnf {ECO:0000313|EMBL:AFB77760.1};
OS   Discoglossus scovazzi.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Alytidae; Discoglossinae; Discoglossus.
OX   NCBI_TaxID=98219 {ECO:0000313|EMBL:AFB77760.1};
RN   [1] {ECO:0000313|EMBL:AFB77760.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=22641173; DOI=10.1016/j.ympev.2012.05.017;
RA   Pabijan M., Crottini A., Reckwell D., Irisarri I., Hauswaldt J.S.,
RA   Vences M.;
RT   "A multigene species tree for Western Mediterranean painted frogs
RT   (Discoglossus).";
RL   Mol. Phylogenet. Evol. 64:690-696(2012).
CC   -!- FUNCTION: Promotes the survival of neuronal populations that are all
CC       located either in the central nervous system or directly connected to
CC       it. {ECO:0000256|RuleBase:RU364086}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU364086}.
CC   -!- SIMILARITY: Belongs to the NGF-beta family.
CC       {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU364086}.
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DR   EMBL; JQ626683; AFB77760.1; -; Genomic_DNA.
DR   AlphaFoldDB; I6NWZ7; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR020430; Brain-der_neurotrophic_factor.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR020408; Nerve_growth_factor-like.
DR   InterPro; IPR002072; Nerve_growth_factor-rel.
DR   InterPro; IPR019846; Nerve_growth_factor_CS.
DR   PANTHER; PTHR11589:SF12; BRAIN-DERIVED NEUROTROPHIC FACTOR; 1.
DR   PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR   Pfam; PF00243; NGF; 1.
DR   PIRSF; PIRSF001789; NGF; 1.
DR   PRINTS; PR01912; BDNFACTOR.
DR   PRINTS; PR00268; NGF.
DR   SMART; SM00140; NGF; 1.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR   PROSITE; PS00248; NGF_1; 1.
DR   PROSITE; PS50270; NGF_2; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR001789-1};
KW   Growth factor {ECO:0000256|RuleBase:RU364086}.
FT   DOMAIN          128..235
FT                   /note="Nerve growth factor-related"
FT                   /evidence="ECO:0000259|SMART:SM00140"
FT   DISULFID        136..203
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT   DISULFID        181..232
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT   DISULFID        191..234
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AFB77760.1"
FT   NON_TER         235
FT                   /evidence="ECO:0000313|EMBL:AFB77760.1"
SQ   SEQUENCE   235 AA;  26459 MW;  1204B2E4197E5E5A CRC64;
     TMVISYFSCM KAAPMKEASV RGQSGLAYPG LRTHGTLESI GGPMSASRGG GLPSLTDTFE
     QVIEELLEEE QNVRQSEENK DSDMYTSRVM LSSQVPLEPP LLFLLEEYKN YLDAANMSMR
     VRRHSDPARR GELSVCDSIS EWVTAADKKT AVDMSGQTVT VLEKVPVPRG QLKQYFYETK
     CNPMGYMKEG CRGIDKRYWN SQCRTTQSYV RALTMDGKKK VGWRFIRIDT SCVCT
//