ID   I6WNP6_BUGNE            Unreviewed;       335 AA.
AC   I6WNP6;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   22-FEB-2023, entry version 32.
DE   SubName: Full=Soluble frizzled-related protein {ECO:0000313|EMBL:AFN44721.1};
OS   Bugula neritina (Brown bryozoan) (Sertularia neritina).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Bryozoa; Gymnolaemata;
OC   Cheilostomatida; Flustrina; Buguloidea; Bugulidae; Bugula.
OX   NCBI_TaxID=10212 {ECO:0000313|EMBL:AFN44721.1};
RN   [1] {ECO:0000313|EMBL:AFN44721.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=22448242; DOI=10.1371/journal.pone.0033323;
RA   Wong Y.H., Wang H., Ravasi T., Qian P.Y.;
RT   "Involvement of Wnt signaling pathways in the metamorphosis of the bryozoan
RT   Bugula neritina.";
RL   PLoS ONE 7:E33323-E33323(2012).
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00090}.
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DR   EMBL; JN900461; AFN44721.1; -; mRNA.
DR   AlphaFoldDB; I6WNP6; -.
DR   MEROPS; I93.002; -.
DR   Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR   InterPro; IPR015526; Frizzled/SFRP.
DR   InterPro; IPR020067; Frizzled_dom.
DR   InterPro; IPR036790; Frizzled_dom_sf.
DR   InterPro; IPR001134; Netrin_domain.
DR   PANTHER; PTHR11309; FRIZZLED; 1.
DR   PANTHER; PTHR11309:SF148; SECRETED FRIZZLED-RELATED PROTEIN 1; 1.
DR   Pfam; PF01392; Fz; 1.
DR   SMART; SM00063; FRI; 1.
DR   SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR   PROSITE; PS50038; FZ; 1.
DR   PROSITE; PS50189; NTR; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00090}.
FT   DOMAIN          25..142
FT                   /note="FZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50038"
FT   DOMAIN          156..303
FT                   /note="NTR"
FT                   /evidence="ECO:0000259|PROSITE:PS50189"
FT   DISULFID        40..86
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT   DISULFID        105..129
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
SQ   SEQUENCE   335 AA;  38258 MW;  41618D0C2ECA1E51 CRC64;
     MIIGGEFLEL DENFDKMWSV SSGRMLQPKC VPIPSNMTLC QNIGYNSMRI PNVLEHDSLE
     EATQQASSWK PLVGVRCHAD TQIFLCSLFS PICLERVILP CRSLCEGVQR SCEGYMKRYG
     FPWPEMFQCD KFPADNDLCI PGRSSTTNQT VDDQVCQPCQ EPDTYEGILD NYCKTQYVIR
     ATIKGLHTES TTAEPGEVEI NMGKRKKRFY KRDTNEPKKV YKLLAEKDAK IYISQGMGCT
     CDQKISPGSH HLMGVRMEKK YNSLGEEVVK FYADFITAWE ENGDTKPGIK RALKAIRKRE
     NVCQGGDNIL NIHKQIEDEE KSVKRVKKNR KALRL
//