ID   I6YX69_TOXGO            Unreviewed;       549 AA.
AC   I6YX69;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   08-NOV-2023, entry version 20.
DE   SubName: Full=Rhoptry protein 5 A {ECO:0000313|EMBL:AFN69377.1};
GN   Name=ROP5A {ECO:0000313|EMBL:AFN69377.1};
OS   Toxoplasma gondii type I.
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC   Eucoccidiorida; Eimeriorina; Sarcocystidae; Toxoplasma.
OX   NCBI_TaxID=1209525 {ECO:0000313|EMBL:AFN69377.1};
RN   [1] {ECO:0000313|EMBL:AFN69377.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=22761577; DOI=10.1371/journal.ppat.1002784;
RA   Niedelman W., Gold D.A., Rosowski E.E., Sprokholt J.K., Lim D.,
RA   Farid Arenas A., Melo M.B., Spooner E., Yaffe M.B., Saeij J.P.;
RT   "The Rhoptry Proteins ROP18 and ROP5 Mediate Toxoplasma gondii Evasion of
RT   the Murine, But Not the Human, Interferon-Gamma Response.";
RL   PLoS Pathog. 8:E1002784-E1002784(2012).
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DR   EMBL; JQ743768; AFN69377.1; -; Genomic_DNA.
DR   AlphaFoldDB; I6YX69; -.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR027916; Kinase-like_dom_Apicomplexa.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR016815; Rhoptry_Rop2-like.
DR   Pfam; PF14531; Kinase-like; 1.
DR   PIRSF; PIRSF022995; Rhoptry_ROP2; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   4: Predicted;
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           25..549
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003707069"
FT   DOMAIN          234..527
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   REGION          28..61
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   549 AA;  60954 MW;  5FDBE69560B82509 CRC64;
     MATKLARLAT WLVLVGCLLW RAGAVQLSPP NSRTNDLASG TPHVARGDTE AQSGTGDDSD
     FPQAVAEEVA DMSGGRVPRV PASSTTTSAS EGIFRRLVRR LRRGRGTADG AGVADETHQE
     PRPPLRKRLA QHFRRLRGFF GRLTPRWLSG LGRRAQRWWR GRQRPLLDPS FHGLEAGDSF
     MRDLLKREKE LIGYCREEAL KEPAAMVEAV TATVWPQNAE TTVDSLLSQG ERKLKLVQPL
     RVGDRSVVFL VRDVERLEYF ALKVFTMGAE NSRSELERLH EATFAAARLL GESPEEARDR
     RRLLLPSDVV AVQSQPPFAQ LSPGQSDYAV ANYLLLMPAA SVDLELLFST LNFVYVFRGG
     EGILARHILT AQLIRLAANL QSKGLVHGRF TPDNLFLMPY GPVMLGDVSA LWKVGTRGPA
     SSVPVTYAPR EFLNANTATF THALNAWQLG LSIYRVWCLF LPFGLVTPGI KGSWKRPSLL
     VPGTDSLSFF PCAPVPDFVE TLIRRFLNFD RRRRLLPLEA METPEFLQLQ NEISRRLSTG
     QPTAAPSVA
//