ID I7BU84_POLSP Unreviewed; 256 AA.
AC I7BU84;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE RecName: Full=Homeobox protein {ECO:0000256|PIRNR:PIRNR037109};
GN Name=HOXD9 {ECO:0000313|EMBL:AFO42778.1};
OS Polyodon spathula (North American paddlefish) (Squalus spathula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Chondrostei; Acipenseriformes; Polyodontidae; Polyodon.
OX NCBI_TaxID=7913 {ECO:0000313|EMBL:AFO42778.1};
RN [1] {ECO:0000313|EMBL:AFO42778.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=22851613;
RA Crow K.D., Smith C.D., Cheng J.F., Wagner G.P., Amemiya C.T.;
RT "An independent genome duplication inferred from Hox paralogs in the
RT American paddlefish--a representative basal ray-finned fish and important
RT comparative reference.";
RL Genome Biol. Evol. 4:937-953(2012).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis.
CC {ECO:0000256|ARBA:ARBA00003263, ECO:0000256|PIRNR:PIRNR037109}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR037109, ECO:0000256|PROSITE-ProRule:PRU00108,
CC ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the Abd-B homeobox family.
CC {ECO:0000256|ARBA:ARBA00006317, ECO:0000256|PIRNR:PIRNR037109}.
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DR EMBL; JX280946; AFO42778.1; -; Genomic_DNA.
DR AlphaFoldDB; I7BU84; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:UniProtKB-UniRule.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR006711; Hox9_activation_N.
DR InterPro; IPR017112; HXA9/HXB9/HXC9.
DR PANTHER; PTHR45970; AGAP004664-PA; 1.
DR PANTHER; PTHR45970:SF4; HOMEOBOX PROTEIN HOX-D9; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF04617; Hox9_act; 1.
DR PIRSF; PIRSF037109; Homeobox_Hox9; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|PIRNR:PIRNR037109};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR037109};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR037109};
KW Transcription {ECO:0000256|PIRNR:PIRNR037109};
KW Transcription regulation {ECO:0000256|PIRNR:PIRNR037109}.
FT DOMAIN 197..256
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT REGION 145..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 156..179
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 256 AA; 28980 MW; 9A3CFAFD611150E6 CRC64;
MSTSGTLSNY YVDAIIGHEV EDVYGARFAQ GAHSTTSRPS GVGDSPDFSS CSFAPKSAVF
SSSWSPVHPQ SSAAVSGIYH PYMHQSHLAA AESRYVRSWI EPLSTSVSFS GFHPNSRHYG
IKPETLPSSK RTECSSFEAQ APSIPDFTSA SFSESKDKPA KAKEPFSNDI SRNSELKEET
QQQLDPSNPA ANWIHARSTR KKRCPYTKYQ TLELEKEFLF NMYLTRDRRY EVARILNLTE
RQVKIWFQNR RMKMKK
//
