ID I7FMY8_9SAUR Unreviewed; 184 AA.
AC I7FMY8;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 22-FEB-2023, entry version 31.
DE SubName: Full=Glial cell line-derived neurotrophic factor {ECO:0000313|EMBL:AFP23125.1};
DE Flags: Fragment;
OS Hemidactylus flaviviridis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Gekkota; Gekkonidae; Gekkoninae;
OC Hemidactylus.
OX NCBI_TaxID=260202 {ECO:0000313|EMBL:AFP23125.1};
RN [1] {ECO:0000313|EMBL:AFP23125.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Testis {ECO:0000313|EMBL:AFP23125.1};
RA Mathur A., Rai U.;
RL Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family. GDNF subfamily.
CC {ECO:0000256|ARBA:ARBA00009832}.
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DR EMBL; JX118849; AFP23125.1; -; mRNA.
DR AlphaFoldDB; I7FMY8; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0030116; F:glial cell-derived neurotrophic factor receptor binding; IEA:InterPro.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0030971; F:receptor tyrosine kinase binding; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR043401; GDNF_fam.
DR InterPro; IPR001839; TGF-b_C.
DR PANTHER; PTHR12173; GDNF SUBFAMILY OF TGF-BETA FAMILY; 1.
DR PANTHER; PTHR12173:SF1; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 2: Evidence at transcript level;
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354}.
FT DOMAIN 74..184
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 64..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 78..99
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AFP23125.1"
FT NON_TER 184
FT /evidence="ECO:0000313|EMBL:AFP23125.1"
SQ SEQUENCE 184 AA; 20662 MW; 8E906D2931E6E9B3 CRC64;
LPAGKTPPEK ARSVPGGTEE EHSSSKLLTP FAGTMDSDMP ENYPKHLGDV VDFIQATIKR
LKRSPDKPAQ FFSRRERNRQ HSAKKTSNSS SRKGRRGPKA KNRDCVLQEI HLNVTDLGLG
YPTKEELIFR YCSGTCESAV TLYDQILNNL TQNRKLVSDK IRPQPCCRPI AFDDDLSFLA
DDLT
//
