ID I7GF95_PIG Unreviewed; 607 AA.
AC I7GF95;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE RecName: Full=Guanine nucleotide-binding protein-like 1 {ECO:0000256|ARBA:ARBA00039902};
GN Name=GNL1 {ECO:0000313|EMBL:BAD83395.1,
GN ECO:0000313|Ensembl:ENSSSCP00000001451.2};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|EMBL:BAD83395.1};
RN [1] {ECO:0000313|EMBL:BAD83395.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Large white {ECO:0000313|EMBL:BAD83395.1};
RX PubMed=16328468; DOI=10.1007/s00251-005-0053-6;
RA Ando A., Shigenari A., Kulski J.K., Renard C., Chardon P., Shiina T.,
RA Inoko H.;
RT "Genomic sequence analysis of the 238-kb swine segment with a cluster of
RT TRIM and olfactory receptor genes located, but with no class I genes, at
RT the distal end of the SLA class I region.";
RL Immunogenetics 57:864-873(2005).
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000001451.2, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000001451.2,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:HDA24065.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30723633; DOI=.7717/peerj.6374;
RA Gilbert D.G.;
RT "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.";
RL PeerJ 7:E6374-E6374(2019).
RN [4] {ECO:0000313|Ensembl:ENSSSCP00000001451.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Possible regulatory or functional link with the
CC histocompatibility cluster. {ECO:0000256|ARBA:ARBA00037770}.
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DR EMBL; AB158488; BAD83395.1; -; Genomic_DNA.
DR EMBL; DQIR01068589; HDA24065.1; -; Transcribed_RNA.
DR EMBL; DQIR01070903; HDA26379.1; -; Transcribed_RNA.
DR EMBL; DQIR01076145; HDA31621.1; -; Transcribed_RNA.
DR EMBL; DQIR01076146; HDA31622.1; -; Transcribed_RNA.
DR EMBL; DQIR01076147; HDA31623.1; -; Transcribed_RNA.
DR EMBL; DQIR01076148; HDA31624.1; -; Transcribed_RNA.
DR EMBL; DQIR01077103; HDA32579.1; -; Transcribed_RNA.
DR EMBL; DQIR01084096; HDA39572.1; -; Transcribed_RNA.
DR EMBL; DQIR01084570; HDA40046.1; -; Transcribed_RNA.
DR EMBL; DQIR01099733; HDA55209.1; -; Transcribed_RNA.
DR EMBL; DQIR01099734; HDA55210.1; -; Transcribed_RNA.
DR EMBL; DQIR01099735; HDA55211.1; -; Transcribed_RNA.
DR EMBL; DQIR01099736; HDA55212.1; -; Transcribed_RNA.
DR EMBL; DQIR01099737; HDA55213.1; -; Transcribed_RNA.
DR EMBL; DQIR01099738; HDA55214.1; -; Transcribed_RNA.
DR EMBL; DQIR01150335; HDB05812.1; -; Transcribed_RNA.
DR EMBL; DQIR01153505; HDB08982.1; -; Transcribed_RNA.
DR EMBL; DQIR01317839; HDC73313.1; -; Transcribed_RNA.
DR RefSeq; NP_001121950.1; NM_001128478.1.
DR PaxDb; 9823-ENSSSCP00000001451; -.
DR Ensembl; ENSSSCT00000001493.5; ENSSSCP00000001451.2; ENSSSCG00000001372.5.
DR GeneID; 100151741; -.
DR KEGG; ssc:100151741; -.
DR CTD; 2794; -.
DR eggNOG; KOG1424; Eukaryota.
DR GeneTree; ENSGT00940000158047; -.
DR HOGENOM; CLU_013649_1_1_1; -.
DR OMA; CDFPVRP; -.
DR OrthoDB; 130417at2759; -.
DR TreeFam; TF324569; -.
DR Proteomes; UP000008227; Chromosome 7.
DR Bgee; ENSSSCG00000001372; Expressed in testis and 43 other cell types or tissues.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR CDD; cd01857; HSR1_MMR1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR030378; G_CP_dom.
DR InterPro; IPR043358; GNL1-like.
DR InterPro; IPR006073; GTP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45709:SF3; GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 1; 1.
DR PANTHER; PTHR45709; LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED; 1.
DR Pfam; PF01926; MMR_HSR1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51721; G_CP; 1.
PE 1: Evidence at protein level;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Proteomics identification {ECO:0007829|PeptideAtlas:I7GF95};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227}.
FT DOMAIN 178..418
FT /note="CP-type G"
FT /evidence="ECO:0000259|PROSITE:PS51721"
FT REGION 1..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 547..607
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..28
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 37..59
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 550..583
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 607 AA; 68746 MW; E82D044280FDCD2A CRC64;
MPRKKPFSVK QKKKQLQDKR ERKRGLQDGL RSSSNSRSGS RERREEQTDT SDGESVTHHI
RRLNQQPSQG LGPRGYDPNR YRLHFERDSR EEVERRKRAA REQVLQPVSA ELLELDIQEV
YQPGSVLDFP RRPPWNYEMS KEQLMSQEER SFQEYLGKIH GAYTSEKLSY FEHNLETWRQ
LWRVLEMSDI VLLITDIRHP VVNFPPALYE YVTGELGLAL VLVLNKVDLA PPALVVAWKH
YFHQHYPQLH IVLFTSFPRD PRTPQDPSSV LKKSRRRGRG WTRALGPEQL LRACEAITAG
KVDLSSWREK IARDVAGATW GNGSGEEEEE EDGPAVLVEQ QTDSAMEPTG PTRERYKDGV
VTIGCVGFPN VGKSSLINGL VGRKVVSVSR TPGHTRYFQT YFLTPSVKLC DCPGLIFPSL
LPRQLQVLAG IYPIAQIQEP YTAVGYLASR IPVQALLHLR HPEAEDPSAE HPWCAWDICE
AWAEKRGYKT AKAARNDVYR AANSLLRLAL DGRLSLCFHP PGYSEQKGTW ESHPETMELV
VLQGRVGPAG DEEEEEEEEL SSSCEEEGEE DRDADEEGEG DEDTPTSAPG SSLAARNPYA
LLGEDEC
//
