ID   I7HZS8_9BRAD            Unreviewed;       225 AA.
AC   I7HZS8;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE            EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
DE   Flags: Fragment;
GN   Name=gyrB {ECO:0000313|EMBL:CCC58409.1};
OS   Bradyrhizobium sp. WSM3990.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC   Nitrobacteraceae; Bradyrhizobium.
OX   NCBI_TaxID=1070028 {ECO:0000313|EMBL:CCC58409.1};
RN   [1] {ECO:0000313|EMBL:CCC58409.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=WSM3990 {ECO:0000313|EMBL:CCC58409.1};
RA   Stepkowski T., Watkin E., McInnes A., Gurda D., Gracz J., Steenkamp E.T.;
RT   "Geographic and climatic barriers shape the composition of Bradyrhizobium
RT   communities nodulating Australia native legumes.";
RL   Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP-dependent breakage, passage and rejoining of double-
CC         stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC   -!- SIMILARITY: Belongs to the type II topoisomerase GyrB family.
CC       {ECO:0000256|ARBA:ARBA00010708}.
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DR   EMBL; HE576503; CCC58409.1; -; Genomic_DNA.
DR   AlphaFoldDB; I7HZS8; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   CDD; cd16928; HATPase_GyrB-like; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR   InterPro; IPR001241; Topo_IIA.
DR   PANTHER; PTHR45866:SF1; DNA GYRASE SUBUNIT B, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR45866; DNA GYRASE/TOPOISOMERASE SUBUNIT B; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   PRINTS; PR00418; TPI2FAMILY.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00433; TOP2c; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT   DOMAIN          1..133
FT                   /note="Histidine kinase/HSP90-like ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00387"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:CCC58409.1"
FT   NON_TER         225
FT                   /evidence="ECO:0000313|EMBL:CCC58409.1"
SQ   SEQUENCE   225 AA;  24585 MW;  A65FF9ADE7C26DBD CRC64;
     VDNAIDEALA GHATRVDVVL NADNSVTVRD DGRGIPVDIH KGEGISAAEV IMTQLHAGGK
     FDQNSYKVSG GLHGVGVSVV NALSSKLGLR IWRDNKEHYI EFAHGDAVAP LVVVGDAPGR
     RGTEVTFQAS PETFKNIEYD FATLEHRLRE LAFLNSGVNI ALSDMRHAVE KREEMHYSGG
     VEEFVKYLDR NKKAIVPAPI MVRAEANGIG VEAALWWNDS YHENV
//