ID I7LW08_TETTS Unreviewed; 581 AA.
AC I7LW08;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Selenocysteine-specific elongation factor {ECO:0000313|EMBL:EAS00534.1};
GN ORFNames=TTHERM_00408870 {ECO:0000313|EMBL:EAS00534.1};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAS00534.1, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
CC -!- FUNCTION: This protein promotes the GTP-dependent binding of aminoacyl-
CC tRNA to the A-site of ribosomes during protein biosynthesis.
CC {ECO:0000256|ARBA:ARBA00003982}.
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DR EMBL; GG662612; EAS00534.1; -; Genomic_DNA.
DR RefSeq; XP_001020779.1; XM_001020779.3.
DR AlphaFoldDB; I7LW08; -.
DR STRING; 312017.I7LW08; -.
DR EnsemblProtists; EAS00534; EAS00534; TTHERM_00408870.
DR GeneID; 7846000; -.
DR KEGG; tet:TTHERM_00408870; -.
DR eggNOG; KOG0461; Eukaryota.
DR HOGENOM; CLU_019148_1_0_1; -.
DR InParanoid; I7LW08; -.
DR OMA; LAFWGRI; -.
DR OrthoDB; 54465at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR CDD; cd04094; eSelB_III; 1.
DR CDD; cd01889; SelB_euk; 1.
DR CDD; cd03696; SelB_II; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR049394; eEFSec_C.
DR InterPro; IPR049393; eEFSec_III.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR PANTHER; PTHR43721:SF11; SELENOCYSTEINE-SPECIFIC ELONGATION FACTOR; 1.
DR Pfam; PF21131; eEFSec_4th; 1.
DR Pfam; PF21208; euk_SelB_III; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Elongation factor {ECO:0000313|EMBL:EAS00534.1};
KW Protein biosynthesis {ECO:0000313|EMBL:EAS00534.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168}.
FT DOMAIN 26..222
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 581 AA; 65255 MW; 26F3E8566998AC3C CRC64;
MVDSVGPSGK YSFTEDELKN INPKTAYNIN IGVLGHIDSG KTSLSKALSV VTSTASMDKN
PQSQERGITL DLGFSAFFTK TPQRLKEQLK LDYLQFTLVD CPGHASLIKT IIGGASIIDI
MFLVIDINKG IQTQTAECLV IGELLMQKMI VVLNKIDMIP EDKRAETISK KMEQLRKVFS
KTKFGASVPM IPIAASQGAI DGQSLHIENL IDCLLGEIEI PQRQKDGPFF FLIDHCFPIK
GKGSVVTGTV IQGQHKAGDE VEFPLIKEVK KSKQIQMFKK PVESIIQGDR AGILFTQLDN
TLIERGIACT PGIIQFISYA IIPVNKVNYF KYPISSKGKF HVTTGHQTLM ASIKLFKVQI
TQEELLILES TKQNINFQTD KNKKDTFNFD FNKEYEYVEN YDDYLKVKKP NECLFALLEF
EKPVCASNGT LFICSKFDTD ITANICRIGF YGNLITQLTQ EELKNKKLKI FREKLREGII
EKVSDDYSVI IKDMFKKETK IEVYVNKPIE ISLTKNVGKI QGAFGKSGKV KAVFPNGVLH
QPIQVNANGE EQKQNQDDIL TEEKLVGQTV ILKYNKILFN K
//
