ID I7M004_TETTS Unreviewed; 1635 AA.
AC I7M004;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Serine/Threonine kinase domain protein {ECO:0000313|EMBL:EAR85242.2};
GN ORFNames=TTHERM_00486930 {ECO:0000313|EMBL:EAR85242.2};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR85242.2, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
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DR EMBL; GG662587; EAR85242.2; -; Genomic_DNA.
DR RefSeq; XP_001032905.2; XM_001032905.2.
DR STRING; 312017.I7M004; -.
DR GeneID; 7831782; -.
DR KEGG; tet:TTHERM_00486930; -.
DR eggNOG; KOG0598; Eukaryota.
DR InParanoid; I7M004; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05123; STKc_AGC; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR045270; STKc_AGC.
DR PANTHER; PTHR24351; RIBOSOMAL PROTEIN S6 KINASE; 1.
DR PANTHER; PTHR24351:SF243; RIBOSOMAL PROTEIN S6 KINASE; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00248; ANK; 2.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 2.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:EAR85242.2};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT REPEAT 509..532
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 543..564
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 1323..1579
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 313..334
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 626..672
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 704..730
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 817..852
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1037..1060
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1085..1169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1092..1169
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 1352
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1635 AA; 184979 MW; 5113BBD77AE4CD4C CRC64;
MLITHLQYIN PSSFYFLSLI KTRSQISLFV ISFNQIERLI ITQIIKKLAQ KLIETRKRKK
LTKKQKLRFH IIIKTKKIIN YYNNKRKEFV NSLTLHLLIL IIISKQRKQK LKRQNKQINK
QHSQNLSLQR VINQFLMKVN QKRNSYTNQQ NQALFSRQQQ QQPINSVSCK NLKSDQYSIQ
DLNKFSPSKM GGKSKQKLIE FQVPRANLDL SSQQQGNKEY LQIQQQHQQS YGNISSQNFG
LQYQNNNYSS PSSFAISSSN SHQKYRSHSS SKILRTLENS LSNNINNPSD QIFNSLCNQS
ANQGNVINNS QLQHSSSLNT AASSSNNNNN MSQLNLSSIN TANMSCNSPS NFMNLQMSFQ
NGFTALNNSI QNPISPNPFT INNTSMIQNQ QQITPISLNS QMNSSLYSVN NGQVSSQAQT
SQGFNIYSQQ KLQILALEQM NKCIQLSSYK EAQKIIESNN ITAEEIYSFK ERSNENIILH
SLALRQDSSV FLKYLDTHMT IEFNQVNSSG QTPLMLACMK GNYDVARFLV SHKSVDINSQ
DLAGNSSLHY ACMYGQRKIV EMLLGQKQVQ SYIKNNDEKQ PKDMTQDSKI LQLFNKFRKV
NLDQSYSSGS AAMNITLSYI NKQDLTNTSQ YKDSPRTNSR SRQNNIQNSA SNSQHHNNQL
QRSHSNSSHS SNLQSLHYNF VSKLNKSTTK NTFLTLKQAL NSQNQTTISG QKNDSNPNSN
KGSSVNSPII KRHHSPNIHL QKAKSAIHPP AVSTFFTQTQ QQANSPTDFI LKGLNQLNES
QVNLGTSNNY VNNNPNNQTN QTASQVLNNS ISMNYFDKNF MTPNNNNNNN QNNPNSYLSS
AEGSNKNQPS QQLNYSTLQQ QNQQFNQSMN ALFNLQPFSQ SKSMNNFLQS NTQSLNSIAN
QIHNPNTLTQ MSQTSRQMTQ GCNQMDNESG SLNYIPINYG MLESVNVSTN NFTPSQLQSN
ITTQNNIGEP INGKKSSQPN LSYVINNSSN LNGNQKAEQT QLLSNGYENE GSAINNISLV
SPSKSISNNT QYFNYKTPSQ TINNNLNNGS QNHNSTAKTQ CNSPLLQSAQ MQHHLNTINK
IIEKKQRSRS QNQFSKAKSQ VGPIAVNQNN NNTNSQQSQA PSNAQAKIST FGTNAAASTP
MNKDQAQENK NSSDSNESTN NTLQTASQQA FHQSVSLKIQ GSNNVSQTNI LTNNSCGPLS
ATSKANFFNS QNQSTKNKQN SQQNVLGAGG QYAFQSAYTS PQLQSSSLQQ FNNQIGHIDQ
IFLNSQTNNQ NNLQQNQQAL LKYLPHNKQS TPNQQSQNIS QIQPQQNFQL SSNQSQLYGI
EIYSVYAHLG SGNYGDVYLV EHNKNKKKYA MKLLDKEKLI QKNMMKYAIA ERNVMQKCNS
PFIVKMYHSF QTDTHLIITM DYCPGGDLYT YLLQKKRFEE ELAVKYLSEI LLAVEELHYH
DVIYRDMKPE NIVLGSDGHV KLIDFGLSRE NMGEGVAQSF CGSAVYLAPE IISKKGHNKS
VDWYQFGVLA YELMVGQPPF NQLNRKELYF NIQNKKVEYP PYLSFKAKSL ISALLNKNPE
ERLGSGRADA QQIKDHPFFD QINWFDVKQK IFDMPKPPAP NPIKDFKVDI KINKNNLSTN
QLIPGWYYID EQELI
//
