ID I7M157_TETTS Unreviewed; 539 AA.
AC I7M157;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Ferric reductase-like transmembrane component family protein {ECO:0000313|EMBL:EAR94978.1};
GN ORFNames=TTHERM_00510180 {ECO:0000313|EMBL:EAR94978.1};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR94978.1, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
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DR EMBL; GG662708; EAR94978.1; -; Genomic_DNA.
DR RefSeq; XP_001015223.1; XM_001015223.1.
DR AlphaFoldDB; I7M157; -.
DR STRING; 312017.I7M157; -.
DR EnsemblProtists; EAR94978; EAR94978; TTHERM_00510180.
DR GeneID; 7842888; -.
DR KEGG; tet:TTHERM_00510180; -.
DR eggNOG; KOG0039; Eukaryota.
DR HOGENOM; CLU_043901_0_0_1; -.
DR InParanoid; I7M157; -.
DR OMA; MEQHRIF; -.
DR OrthoDB; 5489970at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR CDD; cd06186; NOX_Duox_like_FAD_NADP; 1.
DR Gene3D; 3.40.50.80; Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR013112; FAD-bd_8.
DR InterPro; IPR017927; FAD-bd_FR_type.
DR InterPro; IPR013121; Fe_red_NAD-bd_6.
DR InterPro; IPR039261; FNR_nucleotide-bd.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
DR PANTHER; PTHR11972:SF55; FERRIC REDUCTASE; 1.
DR PANTHER; PTHR11972; NADPH OXIDASE; 1.
DR Pfam; PF08022; FAD_binding_8; 1.
DR Pfam; PF08030; NAD_binding_6; 1.
DR SFLD; SFLDS00052; Ferric_Reductase_Domain; 1.
DR SFLD; SFLDG01168; Ferric_reductase_subgroup_(FRE; 1.
DR SUPFAM; SSF52343; Ferredoxin reductase-like, C-terminal NADP-linked domain; 1.
DR SUPFAM; SSF63380; Riboflavin synthase domain-like; 1.
DR PROSITE; PS51384; FAD_FR; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW Transmembrane {ECO:0000256|SAM:Phobius, ECO:0000313|EMBL:EAR94978.1};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 110..132
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 144..166
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 172..191
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 198..215
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 266..371
FT /note="FAD-binding FR-type"
FT /evidence="ECO:0000259|PROSITE:PS51384"
FT DOMAIN 481..539
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT COILED 452..479
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 539 AA; 62292 MW; 93A09AC268CA0ABE CRC64;
MKTDNIQSQM QDSPYIINQK NELIPLETLS LGNKSMQDQP TQIQQKDQVS QFNDQSQRFY
AQKHDQEINH QTVPKNPKKI MSSWKASWHH RFIQYWQSIF NRRIVSFSCF ALQIGDVFIF
SAIVAFCCFA CIEDKQAKSS GNMASILMAA TIVFGCRNGL LSYFFGLSLE RALIWHQLLA
WATLVASLNH WFHSKRLLSG YIIQFPIIAF IFFSIKPVRR YLWELFMKMH WILIIVSIYG
CIAHKVSYAL FAFGYFIIDV CYRMYTIYML SDVSKQIKLE KIGNNITKIS MSSKNVNYKG
GQYFFLMIPK ISYLQWHPFS VFSASYEDEV VFYVKSLGDW TRELYKIAGE QGKPTILKGY
LDGPYGYHSI GIEGDKYKHF LCISGGIGVT PIISTAKEIL KQMEKGRPVN SLHFIWTGRD
SAIVESVLKP DELRSLLNQD DSSILKNFYH YSDKGDKKIE DIEKQAQQEQ QQLVQLSKGR
PEFTKYFESA YNAAKESGES LVAVLTCGPQ QLIDTAEINS MKWSKQGIRF DCHQEVFDF
//
