ID   I7MEW3_TETTS            Unreviewed;       996 AA.
AC   I7MEW3;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 2.
DT   28-JUN-2023, entry version 38.
DE   SubName: Full=PX domain protein {ECO:0000313|EMBL:EAR97919.2};
GN   ORFNames=TTHERM_00283080 {ECO:0000313|EMBL:EAR97919.2};
OS   Tetrahymena thermophila (strain SB210).
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR97919.2, ECO:0000313|Proteomes:UP000009168};
RN   [1] {ECO:0000313|Proteomes:UP000009168}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX   PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA   Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA   Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA   Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA   Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA   Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA   Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA   Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA   Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA   Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA   Hamilton E.P., Orias E.;
RT   "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT   model eukaryote.";
RL   PLoS Biol. 4:1620-1642(2006).
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DR   EMBL; GG662656; EAR97919.2; -; Genomic_DNA.
DR   RefSeq; XP_001018164.2; XM_001018164.2.
DR   AlphaFoldDB; I7MEW3; -.
DR   GeneID; 7841526; -.
DR   KEGG; tet:TTHERM_00283080; -.
DR   InParanoid; I7MEW3; -.
DR   Proteomes; UP000009168; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR   CDD; cd06093; PX_domain; 1.
DR   Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR   InterPro; IPR001683; PX_dom.
DR   InterPro; IPR036871; PX_dom_sf.
DR   Pfam; PF00787; PX; 1.
DR   SUPFAM; SSF64268; PX domain; 1.
DR   PROSITE; PS50195; PX; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        626..642
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        747..776
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          17..132
FT                   /note="PX"
FT                   /evidence="ECO:0000259|PROSITE:PS50195"
FT   REGION          948..996
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        956..996
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   996 AA;  117499 MW;  4EC69013117FD057 CRC64;
     MNQDEVQETI EQALSIDASS IQIVVQEPER KILSSVTYYP IDIQLGEVEK ITVYKRYSEF
     EALYQVLEMK YHNFKFPELP SKLQVFNKSQ TRKKSFQEVF DTILKYAVMY PEKRLDFIQS
     LFVFLLEDIK NKGKKRRIKK SFTLDNSEAG LVSPSLISQT EEAISEDSAS FNDMKGISGS
     MSGGFTQSPI QQNNNNSIQN EIVSKLGSTG ELGTTKETTI QNETQNLTPN DINTQENYQV
     EPEYTFQRRD AIYKMSICSN DDMIVETPVR KRLDSEDLGS KLFNSKCKEK EQEQITKIDE
     VESEEEKISN FNFKMQFKFY YKDKFDTYFV KFKGHDMLLY SKIYDSNFSK LICIHEMIIK
     KSETEENFIE MYHQHDYKPI QIQTTSQRKM NNLINQIEEY GKSTKFDSSN SFTPIGKVVM
     LVNRCLNIGI PNGEPVLIKL KTHHFTFESS IHIHTQNGIF IKQEFSFPIS NPYETIYIEF
     YHLVNDSWLR KKLKENLIGR AKFNYIDMIS LNAGYVIEGM ILDIELVDDN QNNQKKKVPL
     KISVRNDTNR FSIFAKNPQG YEEGEKKMSS IDLFIVSFYR FRRIIGYISK FFQIMEDLFY
     FKYPKLSNLF FAIILLYVIC CDPSRIFTHI FMLIALLCLS FQKDIRQKLD VFFKDQLLDQ
     KNLFFAEPSF LTDDEELYEQ MRNSFDKINI QKIVVEDNDD ESTSIFQKYQ NLKKKFTQIH
     RYLTTICNFC EKIKNIFTWK DPVVTTYLII FLFLLCIIIH ALPIRLFLIV VVLAIYQDGK
     QALKVRRNFN KQISLSVCEY SLRKNLGLSK DQVDFTKQWT KNEKLQKQIT EDFYQHLQVV
     LWEGSLKIFD CPITLSEEIS KCTTLLTLYA GDKIQASDQL FEEIRKQVYP KRSIVENIYY
     YLFNFIYNIP SDYYRLLNPN KIQQHFEEQN QRKNKQIQDQ KTQKLVNQTI KQESSLSPKL
     EKKSNADERN LSKDEKGFNL EDKKLSQEDK KQKKEE
//