ID I7MFL4_TETTS Unreviewed; 1936 AA.
AC I7MFL4;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 2.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Ankyrin repeat protein {ECO:0000313|EMBL:EAS00308.2};
GN ORFNames=TTHERM_00218810 {ECO:0000313|EMBL:EAS00308.2};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAS00308.2, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
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DR EMBL; GG662621; EAS00308.2; -; Genomic_DNA.
DR RefSeq; XP_001020553.2; XM_001020553.2.
DR STRING; 312017.I7MFL4; -.
DR GeneID; 7838231; -.
DR KEGG; tet:TTHERM_00218810; -.
DR eggNOG; KOG4177; Eukaryota.
DR InParanoid; I7MFL4; -.
DR OrthoDB; 181010at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR24193:SF121; ANK_REP_REGION DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24193; ANKYRIN REPEAT PROTEIN; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF13855; LRR_8; 1.
DR SMART; SM00248; ANK; 6.
DR SMART; SM00369; LRR_TYP; 2.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 2.
DR PROSITE; PS51450; LRR; 2.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Coiled coil {ECO:0000256|SAM:Coils};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 646..684
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 773..805
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 210..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 886..911
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 952..1039
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1841..1873
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1495..1535
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 952..997
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1004..1031
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1936 AA; 223792 MW; B68E311AD044D964 CRC64;
MKNSQEVKKP EHSQLQQTSY QASSQSQVSQ IGSFGVNGNF NSINIKKLVQ QSNNYWHAER
NFFNSDKNRN GIDELERMAN SIENILTPKG NFKQQELNKY AYESDQNILN TSNFLHRDSF
CADMHEWPDQ SIDERENVMQ NYEKRNIYTH NIGVGQKKKS EENFDNITGI ISNTAQRSLT
NQANKTNEGN HRRIQSVQSD IKTTQIQNNL GTKHNLPHGQ HLGQGQNSLS NISLNGTTNL
NSQSSGNINA IMSNHKNNQM KNTMMVNMNV NRNYINNANN NQNNMNSNNI PNQASNQNYC
SNQTGFSQKK LQDITFSFNY VKKGASSISK NIFSFNTSTL QIVDLSFNKF RDIPAEILDF
PNLRVLKLDT NLIKVLNPDL FLKVKLEYFS ISNNLLFEIP QLITQWSETL KYLDVSLNRI
EELSVLPSLK RLQSLHIHNN DFRFIPCMIS NFENSLLELS LDWFQYTNPP LQLRQSGLHG
AKIIQKLMHF LKMYSKQDNS IQYIIQKYRY SSQKQDCADV NFIEVVAYLS NQNIPFDINF
RDPKDSNKCL SHKAAEREEI GCLISILEKE YNLINAIDND NHTPLSLSIL HEKFFSAKTL
ISNGANVNLG GSQYGTCLNL ATIKYQYYLV QDLLKRGANP NGADNEGNTP LHYIMTIFHR
DKSYSSKICD LLLQFRADPN IKNKDGWAPI HLVARRGQSD AFEYIQTYNK YLTENNYQNK
RLPEFANLPG VKDGSLMNQQ KTLNTIIQLK DSQNVSGCLQ YMPFHINLKG GKDKQSPLHI
ACMHSCYDIV KELLESGADI FSRNLNNKTP LHLCMKDNYL YKLLKMKESE IFYQFYSLHR
QIQITSPTLY TQETPIKNNI LNRTNTQQSY NLQSSKRQLF QENQPIQSNN NTNQPILNSQ
QKAGTNHSNM SLSSFNAQQQ GQQQNINKNN FSNQALQVAN IIQNNLGQLV NQNNQVMPGN
DQKNSQSNSD FIRPNSLSQN SKQQSKNQLS NNINFDDCDV EISDRDDDEK RDPRTDQLSI
KKNKKMEDNE ENEYDVSESQ LTNRAANFQN LQGLNVKENS KNYNYIQNFE QKFKDSQQSD
LNRIQKGQLI RNSPLLSKQK FKSGEEQNEC LRADEFEGEY DDACVDHEDD SINKQLNDHL
PSNPNYFQQN QIQQSSLSYA TNQKQLNQNY QIDFHQQEIN SLFNQKLNYL NEECDEELNK
EEEFFNADID ESKSMLELIS TKKKIMNQSL PYAPNNIQQL NYIQTVNRTN IQKIQASKAN
HSRSKSNIEG NFLSKISENQ QKAAYSNSQV QKQHFKNQTK DDLVFQKQNP QKGLIKEDGL
DAPPQIITPQ HISFFNYLLE KTKNMHEYYS VSLQNYKKGI LSEFNTLYEK FRYFVIMMKL
QVEYQNMILH LNNEKEMLQS ILGENSILSL GAIDRSNSNL MIMKMLLEIA ENLKCESHSL
LLVQKDYPTP TEQNFFGSVI NINNNITYWM RQYEETIHDT ITQTQSNFQE DQNDVIELVQ
NKKREEKQND NGQNQKDLQE DIKLYERENS ILKENIIYQL GNYDFNEAIN YLEKEIKSED
TSIINAFEAC QSFFQIRESL YQKQSDLNNN KQRKNQISNI QPQPKTYQDD SKALFTFPSN
LISSKQYKVS KQLNSNSVSQ LSSLQELNGS KNQIKQQNTE ASGKNQLINI ISGKNSQNTS
IIFGSDQQDT LNSQKSNISQ QHEKSGLNQG FQYQTQFNNN FLNKYQTNLQ QINNNSNLQK
QQQLEHAQNK KNDSSQTNLN GVTDIILSNP DIHATKPLVS QQNQKFMKHN ENHQFYSLAQ
KQQVLAEKAL NKQLSTHSTG QSQIRDKIFS NDHFSIFEKK QSLNTNNNQL KKDNPKTNTI
NNTQASEDDS NNNSFNLIAP IGAKLDSINN LYIEPQQQEV KQQNKIFQFQ QIKQQQQQQQ
YTLIPISQLK TAQNKK
//
