ID I7MI73_TETTS Unreviewed; 1344 AA.
AC I7MI73;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=E1-E2 ATPase family protein {ECO:0000313|EMBL:EAR90948.2};
GN ORFNames=TTHERM_00145530 {ECO:0000313|EMBL:EAR90948.2};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR90948.2, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC family. Type V subfamily. {ECO:0000256|ARBA:ARBA00006000}.
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DR EMBL; GG662793; EAR90948.2; -; Genomic_DNA.
DR RefSeq; XP_001011193.2; XM_001011193.2.
DR STRING; 312017.I7MI73; -.
DR TCDB; 3.A.3.10.15; the p-type atpase (p-atpase) superfamily.
DR GeneID; 7836611; -.
DR KEGG; tet:TTHERM_00145530; -.
DR eggNOG; KOG0208; Eukaryota.
DR InParanoid; I7MI73; -.
DR OrthoDB; 90931at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140358; F:P-type transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 2.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR006544; P-type_TPase_V.
DR InterPro; IPR001757; P_typ_ATPase.
DR NCBIfam; TIGR01494; ATPase_P-type; 2.
DR PANTHER; PTHR45630:SF8; CATION-TRANSPORTING ATPASE; 1.
DR PANTHER; PTHR45630; CATION-TRANSPORTING ATPASE-RELATED; 1.
DR Pfam; PF13246; Cation_ATPase; 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR PRINTS; PR00119; CATATPASE.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF81660; Metal cation-transporting ATPase, ATP-binding domain N; 1.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 86..102
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 251..271
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 416..436
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1120..1141
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1147..1167
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1188..1209
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1271..1292
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1304..1337
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 829..850
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 866..894
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 959..983
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 875..894
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1344 AA; 154825 MW; 5AC0E05544EED996 CRC64;
MSRKIKEFFI IKQILYFLEK SNLQKIQVTN IFKQYRIRIN FQNSSKVMDE QELKINGQIK
IINSQIEGEC YIQEVYALKQ QQYKQFLVIL LNIITFGGYY LLENWYERSL LKLRYCYTDD
IKQATHFLIV QLDNTFQIVK RNDIMIPEEE NFEIQLQSAI SFDNRFLRYI YSEEEKYFKC
IHFNYTNFLE KNQLGRKGLN QQQLQLLEQC YGKCIMQIPI PSYWSYLHKE LINPFFMFQI
FSVCIWAYDD YYAFCIAITL ILSISTASNI CQIRSNLASF TKIAFYETEI MIKRDKIEKQ
TSSNILPGDL FYINDQMKVP CDCILIQGQA LVNEASLTGE SVPVLKYNYE FNEEVDKKCI
LYEGTSVIQI QNNTSEHGCL ALAIRTGFTT HRGQLVRSIL FPRPHSFKFY EESIKFLKFL
FALTFVAFAI LLPRLYQTME LHYIALKLTD LLTVTVPPSL PFALQVGVVF SMQMLKQKKI
YCINSEKVVV GGRVDTVVFD KTGTLTEDRM DLKGFLPIDD NGNFFKNELV KEDILNVFQK
ENTQHISKSM QISLNCMGSC HSIMIRKNQQ CSPKQDALQN NYKNHLIGDP MEIQLLNISG
CKLYANGDIS SSFGQQFKII KTLEFSSERQ KMTVICEDKS ELIQENKFLY VFSKGAPEAI
HKICNNYPKN YNKMLDKYTQ EGLRVLSLAY KKLPFSLISQ FQQNSSQNTD QNNSNVNTNN
LQPESIESEM NFLGFVFFEN PLKEATAQTL QQLKEAKINI IMATGDNPQT ALSVGEKCHF
FDFEDNVTFI NLAQLGNNKR LTLTNSKFNT YAEVSEVDEL DEYLSDELSS FNSTDSQENK
DQSEQPFGKD KEQLKLLKSL KQAEELNSQG RPRDLISKNE NDERKKLSNK ESSQVDDIEL
KDNILIQQKS SGNKSQTKDI LNGEIKQKCK VNEKQDQLYI CDKNSTTSSS QKIGDESIDI
ENDQQLNKQS NSNSSEDLKE EPDSLHLPIS QYVLDSFIRE ALNQKSEGFV MNGAVFDEIY
FKGEINDLSL MLLEKTRIFA RMKPNHKTYL VELLQKRQKA VAMVGDGAND CGALKQADIG
LALSQLEASI SAPFSGECIS NIIEVLIQCR AGLKTAFNNF NFIAMYSIVQ FTTTTILYYC
FSMQSDLQLL YIDILVVSSL ILTMGMTSAS NKLSMQLPDQ SLISLKNMLS LGGHTLLNII
TQLVILFLLS KQSFFEGIEA NKQFYEKEDI MTWNSSEVST LFLFSNFIYL ALSICYSDGK
PFKNNFYTNK LFICNFMVLL AYCIQMCLVP SLNYYYFYIN TSMSFSWCSF MCIAGIGYIL
LSYFYENTLL GIIYAALQKK TKKE
//
