ID I7MLM5_TETTS Unreviewed; 620 AA.
AC I7MLM5;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 2.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Kelch motif protein {ECO:0000313|EMBL:EAS02707.3};
GN ORFNames=TTHERM_00347970 {ECO:0000313|EMBL:EAS02707.3};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAS02707.3, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
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DR EMBL; GG662523; EAS02707.3; -; Genomic_DNA.
DR RefSeq; XP_001022952.3; XM_001022952.3.
DR AlphaFoldDB; I7MLM5; -.
DR STRING; 312017.I7MLM5; -.
DR GeneID; 7836237; -.
DR KEGG; tet:TTHERM_00347970; -.
DR eggNOG; KOG0379; Eukaryota.
DR eggNOG; KOG1616; Eukaryota.
DR InParanoid; I7MLM5; -.
DR OrthoDB; 179221at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR CDD; cd02859; E_set_AMPKbeta_like_N; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 3.
DR InterPro; IPR032640; AMPK1_CBM.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR PANTHER; PTHR23244:SF506; HOST CELL FACTOR 2-LIKE; 1.
DR PANTHER; PTHR23244; KELCH REPEAT DOMAIN; 1.
DR Pfam; PF16561; AMPK1_CBM; 2.
DR Pfam; PF13415; Kelch_3; 1.
DR Pfam; PF13418; Kelch_4; 2.
DR Pfam; PF13854; Kelch_5; 1.
DR SUPFAM; SSF81296; E set domains; 2.
DR SUPFAM; SSF117281; Kelch motif; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000009168}.
FT DOMAIN 24..105
FT /note="AMP-activated protein kinase glycogen-binding"
FT /evidence="ECO:0000259|Pfam:PF16561"
FT DOMAIN 154..234
FT /note="AMP-activated protein kinase glycogen-binding"
FT /evidence="ECO:0000259|Pfam:PF16561"
FT REGION 593..620
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 593..607
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 620 AA; 72248 MW; 587F995656E7227A CRC64;
MQKTEKVCQN CGYIHVGLCA ANTTDFIWKN GGNVVFLTGS WNQWQTSIKL NKQNENPYYF
TCTMSLQAGT YQYKFIVDGK WTYDQSSPSA EDGFGSFNNV IEVVPRLVVY DETEESEEDE
RILKQIEGNQ NKTQEQMNID NWDYGGRLVK ITTTLEAPDI KIKGSWDNWQ ADQKMIRQFN
NYKNNYENIT KLKLKPGRYE FKFMCNGIFM HDPNQKCIRN QYGTYNNIIY VEQPSSSLVS
YSNAMLNSMS KIKQPELDCT RLVWKSLQFQ HVSWEKMRGQ IQGHSMNRVG DYIYIYGGYR
GSYLDTMWEM NINTYEVDIV DTKGSAPEER AYHQINNFGN KLLMYGGLNN ERILRDYYVY
NTSTRSWDAA DLRGIKPSKR EKNTLSILGK KALILFGGYY CSEDFEAEFH YNDLYCLNLQ
NLTWTELRPE SVLPEPRFSH SANIYKHRMF VFGGMQKIMA SPAKNFNDVW MIDLEPVETE
LKWENLTPFI KGQPPAPRHG HISVLVRKKI LIFGGRGENK QLYNDTFVFD TKNREWIKPQ
IEGEPPRPRF YHAACLTDKE IVIFGGNLTL GQTGIKQKNK SVYILKFEED KKDQGNKKVK
NGFREGESDE DEYGEEQKNN
//
