ID   I8RGG6_9FIRM            Unreviewed;       702 AA.
AC   I8RGG6;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   SubName: Full=KR domain protein {ECO:0000313|EMBL:EIW16835.1};
DE   Flags: Fragment;
GN   ORFNames=FB4_4658 {ECO:0000313|EMBL:EIW16835.1};
OS   Pelosinus fermentans B4.
OC   Bacteria; Bacillota; Negativicutes; Selenomonadales; Sporomusaceae;
OC   Pelosinus.
OX   NCBI_TaxID=1149862 {ECO:0000313|EMBL:EIW16835.1, ECO:0000313|Proteomes:UP000004324};
RN   [1] {ECO:0000313|EMBL:EIW16835.1, ECO:0000313|Proteomes:UP000004324}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B4 {ECO:0000313|EMBL:EIW16835.1,
RC   ECO:0000313|Proteomes:UP000004324};
RX   PubMed=22933770; DOI=10.1128/JB.01174-12;
RA   Brown S.D., Podar M., Klingeman D.M., Johnson C.M., Yang Z.K.,
RA   Utturkar S.M., Land M.L., Mosher J.J., Hurt R.A.Jr., Phelps T.J.,
RA   Palumbo A.V., Arkin A.P., Hazen T.C., Elias D.A.;
RT   "Draft Genome Sequences for Two Metal-Reducing Pelosinus fermentans Strains
RT   Isolated from a Cr(VI)-Contaminated Site and for Type Strain R7.";
RL   J. Bacteriol. 194:5147-5148(2012).
CC   -!- PATHWAY: Antibiotic biosynthesis; bacillaene biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00004789}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EIW16835.1}.
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DR   EMBL; AKVJ01000040; EIW16835.1; -; Genomic_DNA.
DR   AlphaFoldDB; I8RGG6; -.
DR   OrthoDB; 2460252at2; -.
DR   Proteomes; UP000004324; Unassembled WGS sequence.
DR   CDD; cd08953; KR_2_SDR_x; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR   InterPro; IPR049490; C883_1060-like_KR_N.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR042104; PKS_dehydratase_sf.
DR   InterPro; IPR020807; PKS_DH.
DR   InterPro; IPR049551; PKS_DH_C.
DR   InterPro; IPR049552; PKS_DH_N.
DR   InterPro; IPR013968; PKS_KR.
DR   PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR   Pfam; PF21394; Beta-ketacyl_N; 1.
DR   Pfam; PF08659; KR; 1.
DR   Pfam; PF21089; PKS_DH_N; 1.
DR   Pfam; PF14765; PS-DH; 1.
DR   SMART; SM00826; PKS_DH; 1.
DR   SMART; SM00822; PKS_KR; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
FT   DOMAIN          3..163
FT                   /note="Polyketide synthase dehydratase"
FT                   /evidence="ECO:0000259|SMART:SM00826"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:EIW16835.1"
FT   NON_TER         702
FT                   /evidence="ECO:0000313|EMBL:EIW16835.1"
SQ   SEQUENCE   702 AA;  78668 MW;  D0952AF6F59778AC CRC64;
     PIHPLVQRNT SDLSEQRFSS TFTGQEFFLK DHVVKGKKVL PGAAYIEMAR AAVEQAAGGG
     NEEKTRVRLT NMVWMRPILV DTQAAKIHIG LYPEPTGEIT YEIYDEAEVY SKGNAVLISG
     TEAPDLDIEA WKTRCNRSLF SSGQCYETFK EMGMEYGPGH RGIDTVYLGE NQVLAKLSLP
     STVSHTRDQY IVHPSLLDSA LQASSYLLME QGEGTKTMLP FALQEVEVID HCTPAMWALI
     RYHTGSANKD KIKKIDIDLC NETGKICIKI KGFSTRVLEE KAGAFETAAK KSVLLFHPCW
     KEKASTPSIP PLYEQRLVIL CEPDQKIQES IEGSQPEIQH LVLQCQEKGI EERFQAYAIQ
     IFEQIQIMMK NKRKENILIQ IVVVKKNEGQ LFFGLSGLLK TAQLENPKLR GQIIEVDREE
     ETGEVVKKVE KNSYSLDFQI RYQNGKRYVM EWKEIEDSQE KSSIPWKDQG VYLITGGIGG
     LGRIFTREII SKAKDTTIIL TGRSPLNEEK RGTLKELEAK GGKIEYKQVD VTDKKGIIHL
     VQSISKEYGN LDGIIHGAGI IQDNFIFKKS KEEMQKVISP KVSGLVNLDE ASKGLPLDFF
     IFFSSIAGSL GNAGQSDYSV ANAFMDSYAN YRNELVGLKE RYGRTLSVNW PLWKEGGMHV
     DEEVAKRMLQ KMGILPLETA AGIQALYRGL ASGAEQVMVL EG
//