ID I8TVA2_ASPO3 Unreviewed; 1146 AA.
AC I8TVA2;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Ras1 guanine nucleotide exchange factor {ECO:0000313|EMBL:EIT78330.1};
GN ORFNames=Ao3042_05460 {ECO:0000313|EMBL:EIT78330.1};
OS Aspergillus oryzae (strain 3.042) (Yellow koji mold).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=1160506 {ECO:0000313|EMBL:EIT78330.1, ECO:0000313|Proteomes:UP000002812};
RN [1] {ECO:0000313|EMBL:EIT78330.1, ECO:0000313|Proteomes:UP000002812}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3.042 {ECO:0000313|EMBL:EIT78330.1,
RC ECO:0000313|Proteomes:UP000002812};
RX PubMed=22933657; DOI=10.1128/EC.00160-12;
RA Zhao G., Yao Y., Qi W., Wang C., Hou L., Zeng B., Cao X.;
RT "Draft genome sequence of Aspergillus oryzae strain 3.042.";
RL Eukaryot. Cell 11:1178-1178(2012).
RN [2] {ECO:0000313|Proteomes:UP000002812}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3.042 {ECO:0000313|Proteomes:UP000002812};
RA Zhao G., Hou L., Wang C., Cao X.;
RT "Comparative genomic analyses of Aspergillus oryzae 3.042 and A. oryzae
RT RIB40 for soy-sauce fermentation.";
RL Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EIT78330.1}.
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DR EMBL; AKHY01000139; EIT78330.1; -; Genomic_DNA.
DR AlphaFoldDB; I8TVA2; -.
DR HOGENOM; CLU_002116_1_0_1; -.
DR Proteomes; UP000002812; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23113:SF354; BUD SITE SELECTION PROTEIN 5; 1.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 57..123
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 677..797
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 857..1100
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 32..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 268..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 510..560
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 585..604
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1098..1121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 524..560
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 586..604
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1146 AA; 127729 MW; 54332F3DE8828D04 CRC64;
MEPMKPHIAP LKIEKGNSNF YSNRFYCTQH HQMTPPLTPS NTKKDDSMEE TETPRAVFHN
YLRAFYPFHP SGDVSPATIT LPLDQGDIIL VHSVHTNGWA DGTLLDTGAR GWLPTNYCEA
YDQLPMRPLL KALTDFWDII QGGCGFPLRE FCNQDTVKGL IAGVRFLLEK SECLTRDSVL
VRSHDGLRRN RKALLADLSS LVRTTKRCQE MPSSTNDTEH EVCMMDEMLL KAFRIVTRGV
RFLDIWTEEV GLSRTIAELG QATHFDILPT PMSETFPSEA DTERGESRLL NRSRLDMSRA
SNRTDTIESQ SHRPVSVSTK RISHRVSCSA PAAASRNPNL ASERLNTTYD AFLGVLGSFI
GLHLQSRPST ELVVTTEQAV RSCRGLLTVV EAVCEHDPQG CGLLEQARDT MYDRLSELVY
AARDAFRPAH SADDELIFMP DEGKRLVDAA TDCVRGAGNC LAKARWMLEQ SGDFELEALT
QDSSTVHDIQ TTPIPQRTGS LAGDQKEVSL RLPPPPLEIP VKKNLRDSTS TPGLTEAATP
SSFNSRALVT PTTDNTDQPT AMLSTSLDKM STSLMQDAHV ADSIQCRDSH PTSEVSESFG
RGITSTGSSF TYNSHLRDSE MSGVSQTSTR ATSPDICNSY QAPSLHGSIS HSTLAEENEE
TEANILEKTF AHELIFKDGQ VMGGSLRALV EKLTAHGSTP DAMFVSAFYL TFRLFATPME
FAETLVDRFI YIGDTPHAAG PVRLRVYNVF KGWLESHWRH DCDNVALDFI MNFANTTLMQ
NLPSAGKRLA ELAEKVSAVH GPVVPRLVSS MGKTNTATAQ YVHPDAPLPP PILGKKENNL
LRQWKHGEGS LSILDFDPME LARQFTIKES RIFCSILPEE LLATEWMKKS ASLAVNVRAM
STLSTDLAHL VADSILQLEE PKKRAATIKH WVKIANKCLE LDNYDTLMAI ICSLNSSMIS
RLKRTWEIVS QKTKTTLESL RGIVDVSRNY AVLRQRLQNR IPPCLPFVGT YLTDLTFVDH
GNQPLRSLPT EDGEMAVINF DKHMKTAKII SELQRFQIPY RLTEVPELQA WMQNELIRVR
SSGEKSMQTF YRRSLVLEPR DPPQTPRSIP PQPESSASSI LENAKDKFDF LSWTHPSKAK
SVATNG
//
