ID I9Q3M5_9BACE Unreviewed; 644 AA.
AC I9Q3M5;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Glycoside hydrolase {ECO:0008006|Google:ProtNLM};
GN ORFNames=HMPREF1062_04929 {ECO:0000313|EMBL:EIY23711.1};
OS Bacteroides cellulosilyticus CL02T12C19.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=997874 {ECO:0000313|EMBL:EIY23711.1, ECO:0000313|Proteomes:UP000003741};
RN [1] {ECO:0000313|EMBL:EIY23711.1, ECO:0000313|Proteomes:UP000003741}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL02T12C19 {ECO:0000313|EMBL:EIY23711.1,
RC ECO:0000313|Proteomes:UP000003741};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Zitomersky N.L., Coyne M.J.,
RA Comstock L.E., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A., Chapman S.B.,
RA Gearin G., Goldberg J., Griggs A., Gujja S., Hansen M., Heiman D.,
RA Howarth C., Larimer J., Lui A., MacDonald P.J.P., McCowen C.,
RA Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M., Roberts A.,
RA Saif S., Shea T., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Bacteroides cellulosilyticus CL02T12C19.";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 43 family.
CC {ECO:0000256|ARBA:ARBA00009865}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EIY23711.1}.
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DR EMBL; AGXG01000104; EIY23711.1; -; Genomic_DNA.
DR AlphaFoldDB; I9Q3M5; -.
DR PATRIC; fig|997874.3.peg.5043; -.
DR HOGENOM; CLU_010779_2_0_10; -.
DR OrthoDB; 9763933at2; -.
DR Proteomes; UP000003741; Unassembled WGS sequence.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR CDD; cd08983; GH43_Bt3655-like; 1.
DR CDD; cd18828; GH43_BT3675-like; 1.
DR InterPro; IPR006710; Glyco_hydro_43.
DR InterPro; IPR023296; Glyco_hydro_beta-prop_sf.
DR PANTHER; PTHR43772:SF2; BETA-1,4-XYLOSIDASE (EUROFUNG); 1.
DR PANTHER; PTHR43772; ENDO-1,4-BETA-XYLANASE; 1.
DR Pfam; PF04616; Glyco_hydro_43; 2.
DR SUPFAM; SSF75005; Arabinanase/levansucrase/invertase; 2.
PE 3: Inferred from homology;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Polysaccharide degradation {ECO:0000256|ARBA:ARBA00022651};
KW Signal {ECO:0000256|SAM:SignalP};
KW Xylan degradation {ECO:0000256|ARBA:ARBA00022651}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..644
FT /note="Glycoside hydrolase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003723785"
FT ACT_SITE 349
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR606710-1"
FT ACT_SITE 529
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR606710-1"
FT SITE 474
FT /note="Important for catalytic activity, responsible for
FT pKa modulation of the active site Glu and correct
FT orientation of both the proton donor and substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR606710-2"
SQ SEQUENCE 644 AA; 72919 MW; 5218161EF7461866 CRC64;
MRNTMKQFAI AISLMLAITL PSFSQQQHPI VEKDYVAYLF TYFTGNHISE EAVCYAVSMD
GYTYWALNDG KPVLDSKVIS STGGVRDPHI LRSQDGHTFY MVVTDMVSDN GWDSNRAMVL
LKSNDLVNWT HSIINMQKRY KGQEKLKRVW APQTVFDPEA GKYMVYWSMQ YAGGADIIYY
AYANDDFTDL IGEPKPLFIP ENKKSCIDGD IVYKDGVFHL FYKTEGHGNG IKVATTRSLT
SGQWKEEPDY KQQTKDAVEG AGTFKLINQD KYILMYDVYM KGKYQFTETT DLKNFKVIDS
EVKMNFHPRH GTIIPITRDE LIRITDKWGR PAELGAIPNN PVLPGFHADP EILYSNKTKK
YYIYSTTDGQ PGWGGWYFTV FSSTDLKNWN YEGVMLDLKS EQVPWANGNA WAPCIEEKLI
KGEYKYFFYY SGNPAKGGGK QIGVAMADSP TGPFTDLGQP IITDSPVGHG QQIDVDVFTD
PVSGKSYLYW GNGYMAGAEL NKDMISIKKK TLTVMTPEGG TLQDYAFREA PYVFYRNGLY
YFMWSVDDTG SPNYHVAYGT SKSPLGPIEV AKDPIVLIQN PEKQIYGPAH NAVLQIPGTD
EWYIVYHRIN KNFLKDGPGV HREVCIDRME FNADGTIKPV VPTL
//
