ID I9SDC6_HELPX Unreviewed; 845 AA.
AC I9SDC6;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 24-JAN-2024, entry version 48.
DE SubName: Full=DNA segregation ATPase FtsK/SpoIIIE, S-DNA-T family {ECO:0000313|EMBL:EJB54674.1};
GN Name=ftsK {ECO:0000313|EMBL:EJB54674.1};
GN ORFNames=HPHPH28_1130 {ECO:0000313|EMBL:EJB54674.1};
OS Helicobacter pylori Hp H-28.
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=992041 {ECO:0000313|EMBL:EJB54674.1, ECO:0000313|Proteomes:UP000005158};
RN [1] {ECO:0000313|EMBL:EJB54674.1, ECO:0000313|Proteomes:UP000005158}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hp H-28 {ECO:0000313|EMBL:EJB54674.1,
RC ECO:0000313|Proteomes:UP000005158};
RA Blanchard T.G., Czinn S.J., McCracken C., Abolude K., Maroo A.,
RA Santana-Cruz I., Tallon L.J., Ficke F.W.F.;
RT "Genome sequence of Helicobacter pylori Hp H-28.";
RL Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the FtsK/SpoIIIE/SftA family.
CC {ECO:0000256|ARBA:ARBA00006474}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJB54674.1}.
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DR EMBL; AKOI01000011; EJB54674.1; -; Genomic_DNA.
DR RefSeq; WP_000837219.1; NZ_AKOI01000011.1.
DR AlphaFoldDB; I9SDC6; -.
DR PATRIC; fig|992041.3.peg.1098; -.
DR Proteomes; UP000005158; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR CDD; cd01127; TrwB_TraG_TraD_VirD4; 1.
DR Gene3D; 3.30.980.40; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041027; FtsK_alpha.
DR InterPro; IPR002543; FtsK_dom.
DR InterPro; IPR018541; Ftsk_gamma.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR22683:SF41; DNA TRANSLOCASE FTSK; 1.
DR PANTHER; PTHR22683; SPORULATION PROTEIN RELATED; 1.
DR Pfam; PF17854; FtsK_alpha; 1.
DR Pfam; PF09397; FtsK_gamma; 1.
DR Pfam; PF01580; FtsK_SpoIIIE; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00843; Ftsk_gamma; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50901; FTSK; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00289}; DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00289}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..25
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 45..67
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 117..135
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 519..709
FT /note="FtsK"
FT /evidence="ECO:0000259|PROSITE:PS50901"
FT REGION 175..211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 235..328
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 178..210
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 281..306
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 307..324
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 536..543
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00289"
SQ SEQUENCE 845 AA; 94711 MW; E3DBCE05AED1B1FA CRC64;
MKSKKLYLAL IIGVLLAFLT LSSWLGNSGL VGRFGVWFAA INKKYFGYLS LINLPYLAWV
LFLLYKAKNP FTEIVLEKTL GHLLGILSLL FLQSSLLNQG EIGNSARLFL RPFIGDFGLY
ALIMLMVVIS YLILFKLPPK SVFYPYINKT QNLLKEIYKQ CLQAFSPNFS LKKEGFENTS
SDTQKKETKN EKEKENLKEN PIDENHKTPN EESFLAIPTP YNTTLNDLKP QEGLVQISSH
PPTHYTIYPK KNRFDDLSNP TNPTLKETKQ ETKEREPTPT KETLTPTTPK PIMSAPAPNT
ENDNKTQNHK APNHPIKEEN AQENAQEEMI EENLKEEEAQ DAPSFSPVIP TSTKKPVMVK
ELSENKEILD GLDYGEVQKP KDYELPTTQL LNAVCLKDTS LDENEIDQKI QDLLSKLRTF
KIDGDIIRTY SGPIVTTFEF RPAPNVKVSR ILGLSDDLAM TLCAESIRIQ APIRGKDVVG
IEIPNSQSQV IYLREILESE LFQKSSSPLT LALGKDIVGN PFITDLKKLP HLLIAGTTGS
GKSVGVNAMI LSLLYKNPPD QLKLVMIDPK MVEFSIYADI PHLLTPIITD PKKAIGALQS
VAKEMERRYS LMSEYKVKTI DSYNEQAENN GVEAFPYLIV VIDELADLMM TGGKEAEFPI
ARIAQMGRAS GLHLIVATQR PSVDVVTGLI KTNLPSRVSF RVGTKIDSKV ILDTDGAQSL
LGRGDMLFTP PGTNGLVRLH APFATEDEIK KIVDFIKAQK EVQYDKDFLL EESRMPLDTP
NYQGDDILER AKAVILEKKI TSTSFLQRQL KIGYNQAATI TDELEAQGFL SPRNAKGNRE
ILQNF
//
