ID I9UJH8_HELPX Unreviewed; 359 AA.
AC I9UJH8;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Methyltransferase {ECO:0000256|RuleBase:RU362026};
DE EC=2.1.1.- {ECO:0000256|RuleBase:RU362026};
GN Name=hpyAIVM {ECO:0000313|EMBL:EJB80414.1};
GN ORFNames=HPHPH6_1572 {ECO:0000313|EMBL:EJB80414.1};
OS Helicobacter pylori Hp H-6.
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=992061 {ECO:0000313|EMBL:EJB80414.1, ECO:0000313|Proteomes:UP000004177};
RN [1] {ECO:0000313|EMBL:EJB80414.1, ECO:0000313|Proteomes:UP000004177}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hp H-6 {ECO:0000313|EMBL:EJB80414.1,
RC ECO:0000313|Proteomes:UP000004177};
RX PubMed=23661595; DOI=10.1111/2049-632X.12045;
RA Blanchard T.G., Czinn S.J., Correa P., Nakazawa T., Keelan M.,
RA Morningstar L., Santana-Cruz I., Maroo A., McCracken C., Shefchek K.,
RA Daugherty S., Song Y., Fraser C.M., Fricke W.F.;
RT "Genome sequences of 65 Helicobacter pylori strains isolated from
RT asymptomatic individuals and patients with gastric cancer, peptic ulcer
RT disease, or gastritis.";
RL Pathog. Dis. 68:39-43(2013).
CC -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00006594, ECO:0000256|RuleBase:RU362026}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJB80414.1}.
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DR EMBL; AKOZ01000007; EJB80414.1; -; Genomic_DNA.
DR AlphaFoldDB; I9UJH8; -.
DR PATRIC; fig|992061.3.peg.1544; -.
DR Proteomes; UP000004177; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0006306; P:DNA methylation; IEA:InterPro.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002941; DNA_methylase_N4/N6.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR001091; RM_Methyltransferase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR13370:SF32; DNA ADENINE METHYLTRANSFERASE YHDJ; 1.
DR PANTHER; PTHR13370; RNA METHYLASE-RELATED; 1.
DR Pfam; PF01555; N6_N4_Mtase; 1.
DR PRINTS; PR00508; S21N4MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:EJB80414.1};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EJB80414.1}.
FT DOMAIN 28..249
FT /note="DNA methylase N-4/N-6"
FT /evidence="ECO:0000259|Pfam:PF01555"
SQ SEQUENCE 359 AA; 41963 MW; 2F51E88DB28D8867 CRC64;
MDFLKENLNA IIEGDCLERL KDFPNKSVDF IFADPPYFMQ TEGELKRFEG TKFQGVEDHW
DKFGSFEEYD TFCLGWLKEC QRILKDNGSI CVIGSFQNIF RIGFHLQNLG FWILNDIIWH
KSNPVPNFAG KRLCNAHETL IWCAKHKNSK VTFNYKTMKY LNNDKQEKSV WQIPICMGNE
RLKDAQGKKV HSTQKPEALL KKIILSATKP KDIVLDPFFG TGTTGAVAKS MNRYFIGIEK
DSFYIKEAIK RLNNARDKSD FITNLELETK PPKIPMRLLI SKQLLKIGDF LYSSNKEKIC
QVLENGQVRD NENYETSIHK MSAKYLNKTN HNGWKFFYAY YQNQFLLLDE LRYICQKDS
//
