ID I9VP09_BACFG Unreviewed; 232 AA.
AC I9VP09;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=D-lactate dehydratase {ECO:0000256|ARBA:ARBA00013134};
DE EC=4.2.1.130 {ECO:0000256|ARBA:ARBA00013134};
GN ORFNames=HMPREF1080_02286 {ECO:0000313|EMBL:EIY97536.1};
OS Bacteroides fragilis CL05T12C13.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=997881 {ECO:0000313|EMBL:EIY97536.1, ECO:0000313|Proteomes:UP000003917};
RN [1] {ECO:0000313|EMBL:EIY97536.1, ECO:0000313|Proteomes:UP000003917}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL05T12C13 {ECO:0000313|EMBL:EIY97536.1,
RC ECO:0000313|Proteomes:UP000003917};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Zitomersky N.L., Coyne M.J.,
RA Comstock L.E., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A., Chapman S.B.,
RA Gearin G., Goldberg J., Griggs A., Gujja S., Hansen M., Heiman D.,
RA Howarth C., Larimer J., Lui A., MacDonald P.J.P., McCowen C.,
RA Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M., Roberts A.,
RA Saif S., Shea T., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Bacteroides fragilis CL05T12C13.";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + methylglyoxal = (R)-lactate + H(+);
CC Xref=Rhea:RHEA:27754, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16004, ChEBI:CHEBI:17158; EC=4.2.1.130;
CC Evidence={ECO:0000256|ARBA:ARBA00001524};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EIY97536.1}.
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DR EMBL; AGXP01000025; EIY97536.1; -; Genomic_DNA.
DR RefSeq; WP_005802772.1; NZ_JH724194.1.
DR AlphaFoldDB; I9VP09; -.
DR PATRIC; fig|997881.3.peg.2395; -.
DR HOGENOM; CLU_070319_2_0_10; -.
DR Proteomes; UP000003917; Unassembled WGS sequence.
DR CDD; cd03141; GATase1_Hsp31_like; 1.
DR Gene3D; 3.40.50.880; -; 1.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR002818; DJ-1/PfpI.
DR PANTHER; PTHR48094:SF11; GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED; 1.
DR PANTHER; PTHR48094; PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED; 1.
DR Pfam; PF01965; DJ-1_PfpI; 1.
DR SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
PE 4: Predicted;
KW Stress response {ECO:0000256|ARBA:ARBA00023016}.
FT DOMAIN 28..226
FT /note="DJ-1/PfpI"
FT /evidence="ECO:0000259|Pfam:PF01965"
SQ SEQUENCE 232 AA; 25712 MW; D2A5C4A8A8A053F9 CRC64;
MDALKMLIVV TGTDMYADGN LQTGLWLSEL THIYHCAEEA GYEITVASPK GGNVPVDPES
LKPMMLDKLS KDYWDDLEFR RELQHAKSLA EVSGQLFDCV YLAGGHGAMY DFPDDTVLQA
IIEKHYESDK AVAAICHGVS GLLNVKLSGG EYLIKDKKIT GFSWFEESLA GRKKEVPFDL
EAALEKRGAD YEKALIPMTS KVVVDGNLIT GQNPFSSKEM AEVVMRQLSR EK
//
