ID I9X2E6_HELPX Unreviewed; 350 AA.
AC I9X2E6;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=tRNA-5-methylaminomethyl-2-thiouridylate-methyltransferase {ECO:0000313|EMBL:EJC09885.1};
DE EC=2.1.1.61 {ECO:0000313|EMBL:EJC09885.1};
GN Name=trmE1 {ECO:0000313|EMBL:EJC09885.1};
GN ORFNames=HPHPP13_0101 {ECO:0000313|EMBL:EJC09885.1};
OS Helicobacter pylori Hp P-13.
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=992079 {ECO:0000313|EMBL:EJC09885.1, ECO:0000313|Proteomes:UP000005544};
RN [1] {ECO:0000313|EMBL:EJC09885.1, ECO:0000313|Proteomes:UP000005544}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hp P-13 {ECO:0000313|EMBL:EJC09885.1,
RC ECO:0000313|Proteomes:UP000005544};
RX PubMed=23661595; DOI=10.1111/2049-632X.12045;
RA Blanchard T.G., Czinn S.J., Correa P., Nakazawa T., Keelan M.,
RA Morningstar L., Santana-Cruz I., Maroo A., McCracken C., Shefchek K.,
RA Daugherty S., Song Y., Fraser C.M., Fricke W.F.;
RT "Genome sequences of 65 Helicobacter pylori strains isolated from
RT asymptomatic individuals and patients with gastric cancer, peptic ulcer
RT disease, or gastritis.";
RL Pathog. Dis. 68:39-43(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJC09885.1}.
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DR EMBL; AKPO01000002; EJC09885.1; -; Genomic_DNA.
DR AlphaFoldDB; I9X2E6; -.
DR PATRIC; fig|992079.3.peg.99; -.
DR Proteomes; UP000005544; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004810; F:CCA tRNA nucleotidyltransferase activity; IEA:InterPro.
DR GO; GO:0004808; F:tRNA (5-methylaminomethyl-2-thiouridylate)(34)-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd01712; ThiI; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR020536; ThiI_AANH.
DR PANTHER; PTHR11933:SF6; THIL AANH DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR11933; TRNA 5-METHYLAMINOMETHYL-2-THIOURIDYLATE -METHYLTRANSFERASE; 1.
DR Pfam; PF18297; NFACT-R_2; 1.
DR Pfam; PF03054; tRNA_Me_trans; 1.
DR SUPFAM; SSF52402; Adenine nucleotide alpha hydrolases-like; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Methyltransferase {ECO:0000313|EMBL:EJC09885.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transferase {ECO:0000313|EMBL:EJC09885.1}.
SQ SEQUENCE 350 AA; 40066 MW; 80D864EE1AF01DC7 CRC64;
MKQIKALALF SGGLDSLLSM KLLIDQGIEV TALHFNIGFG GNKDKREYFE NATAQIGAKL
LVCDIREQFF NDVLFKPKYG YGKYFNPCID CHANMFRNAF YKMLELDADF VLSGEVLGQR
PKSQRKEALN QVRKLVREVG EEARFDPILD RTQAGGEKPQ FLDELLLRPM SAKLLEPTFM
EKKGWVDREK LLDVSGRGRA RQLQMIKDYG LKYYEKPGGG CLLTDIQVSN KIKNLKEYRE
MVFEDSVIVK IGRYFVLPHN ARLVVARNEE ENHKLDIQHP LMDKIELLGC KGPLSLVDKN
ASKEDKELAG RIALGYAKTL KNQAYLIQIG NEKRELYPLD KESAREYLFA
//
