ID I9YFS4_HELPX Unreviewed; 545 AA.
AC I9YFS4;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN Name=vspIM {ECO:0000313|EMBL:EJC30007.1};
GN ORFNames=HPHPP11B_0581 {ECO:0000313|EMBL:EJC30007.1};
OS Helicobacter pylori Hp P-11b.
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=992106 {ECO:0000313|EMBL:EJC30007.1, ECO:0000313|Proteomes:UP000005601};
RN [1] {ECO:0000313|EMBL:EJC30007.1, ECO:0000313|Proteomes:UP000005601}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hp P-11b {ECO:0000313|EMBL:EJC30007.1,
RC ECO:0000313|Proteomes:UP000005601};
RA Blanchard T.G., Czinn S.J., McCracken C., Abolude K., Maroo A.,
RA Santana-Cruz I., Tallon L.J., Ficke F.W.F.;
RT "Genome sequence of Helicobacter pylori Hp P-11b.";
RL Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJC30007.1}.
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DR EMBL; AKQH01000003; EJC30007.1; -; Genomic_DNA.
DR RefSeq; WP_001139845.1; NZ_AKQH01000003.1.
DR AlphaFoldDB; I9YFS4; -.
DR PATRIC; fig|992106.3.peg.562; -.
DR Proteomes; UP000005601; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR025931; TaqI_C.
DR PANTHER; PTHR33841:SF1; ADENINE-SPECIFIC METHYLTRANSFERASE PGLX; 1.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR Pfam; PF12950; TaqI_C; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:EJC30007.1};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EJC30007.1}.
FT DOMAIN 93..264
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
FT DOMAIN 388..501
FT /note="TaqI-like C-terminal specificity"
FT /evidence="ECO:0000259|Pfam:PF12950"
SQ SEQUENCE 545 AA; 63132 MW; AEBFD2F4DAC4105F CRC64;
MPSNTLSVGE IAHLINVSHS SVHNWIKTNL LEKLEIDHKI YVKTSSFLDF CRNHLGKNKL
NKYANKSLKS AHNHQELILK YLEMLENSSD LEKLGSYYEE ELSNTTRNLE GIYYTPNRIV
EQLFTLPKDF DTSQAIFCDP AVGSGNFVMH ALKLGFKVEN IYGYDTDAFA VALTKKRIKE
RYRLDCPNIM QKDFLNLKHT PQFDCIFTNP PWGKKYNQNQ KENFKQQFNL PQSLDSASLF
FVASLNCLKE NAHLGLLLPE SCLNIDAFSK MREMALKFQM RSLIDFDKPF KNLMTRAVGL
ALKKTPNKNQ KISCFYQNSK FKRSPSSFFN NPKKIFNIHC SSKENKILDH LFSIPHTTLK
NNAHFALGIV IGNNKERLHS KQEKNTIPIF RGSDILKDGL KAPSQFINAD LKDCQQVAPL
SLYQTREKIV YKFISSKLVF FYDNEQRLFL NSANMFVLKE NFPINAHALK ELLNSDLMQF
IFESLFKTHK ILRKDLECLP LFAQFINNGF DEKFYLKNLG IEKKDPKHFT IRKNHACCLS
FGFRG
//
