ID I9YR49_HELPX Unreviewed; 548 AA.
AC I9YR49;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=Membrane protein insertase YidC {ECO:0000256|ARBA:ARBA00015325, ECO:0000256|HAMAP-Rule:MF_01810};
DE AltName: Full=Foldase YidC {ECO:0000256|ARBA:ARBA00033342, ECO:0000256|HAMAP-Rule:MF_01810};
DE AltName: Full=Membrane integrase YidC {ECO:0000256|ARBA:ARBA00033245, ECO:0000256|HAMAP-Rule:MF_01810};
DE AltName: Full=Membrane protein YidC {ECO:0000256|HAMAP-Rule:MF_01810};
GN Name=yidC {ECO:0000256|HAMAP-Rule:MF_01810,
GN ECO:0000313|EMBL:EJC33957.1};
GN ORFNames=HPHPP15B_0052 {ECO:0000313|EMBL:EJC33957.1};
OS Helicobacter pylori Hp P-15b.
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=992108 {ECO:0000313|EMBL:EJC33957.1, ECO:0000313|Proteomes:UP000004543};
RN [1] {ECO:0000313|EMBL:EJC33957.1, ECO:0000313|Proteomes:UP000004543}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hp P-15b {ECO:0000313|EMBL:EJC33957.1,
RC ECO:0000313|Proteomes:UP000004543};
RA Blanchard T.G., Czinn S.J., McCracken C., Abolude K., Maroo A.,
RA Santana-Cruz I., Tallon L.J., Ficke F.W.F.;
RT "Genome sequence of Helicobacter pylori Hp P-15b.";
RL Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC complex formation of integral membrane proteins into the membrane.
CC Involved in integration of membrane proteins that insert both
CC dependently and independently of the Sec translocase complex, as well
CC as at least some lipoproteins. Aids folding of multispanning membrane
CC proteins. {ECO:0000256|HAMAP-Rule:MF_01810}.
CC -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC Specifically interacts with transmembrane segments of nascent integral
CC membrane proteins during membrane integration. {ECO:0000256|HAMAP-
CC Rule:MF_01810}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-Rule:MF_01810};
CC Multi-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_01810}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC {ECO:0000256|ARBA:ARBA00010527, ECO:0000256|HAMAP-Rule:MF_01810}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJC33957.1}.
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DR EMBL; AKQJ01000001; EJC33957.1; -; Genomic_DNA.
DR RefSeq; WP_000375755.1; NZ_AKQJ01000001.1.
DR AlphaFoldDB; I9YR49; -.
DR PATRIC; fig|992108.3.peg.47; -.
DR Proteomes; UP000004543; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR GO; GO:0051205; P:protein insertion into membrane; IEA:UniProt.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd20070; 5TM_YidC_Alb3; 1.
DR CDD; cd19960; YidC_peri; 1.
DR Gene3D; 2.70.98.90; -; 1.
DR HAMAP; MF_01810; YidC_type1; 1.
DR InterPro; IPR019998; Membr_insert_YidC.
DR InterPro; IPR028053; Membr_insert_YidC_N.
DR InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR InterPro; IPR028055; YidC/Oxa/ALB_C.
DR InterPro; IPR047196; YidC_ALB_C.
DR InterPro; IPR038221; YidC_periplasmic_sf.
DR NCBIfam; TIGR03593; yidC_nterm; 1.
DR NCBIfam; TIGR03592; yidC_oxa1_cterm; 1.
DR PANTHER; PTHR12428:SF65; INNER MEMBRANE PROTEIN ALBINO3, CHLOROPLASTIC; 1.
DR PANTHER; PTHR12428; OXA1; 1.
DR Pfam; PF02096; 60KD_IMP; 1.
DR Pfam; PF14849; YidC_periplas; 1.
DR PRINTS; PR00701; 60KDINNERMP.
DR PRINTS; PR01900; YIDCPROTEIN.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475, ECO:0000256|HAMAP-
KW Rule:MF_01810};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|HAMAP-Rule:MF_01810};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_01810};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927, ECO:0000256|HAMAP-
KW Rule:MF_01810};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW Rule:MF_01810};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP-
KW Rule:MF_01810};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|HAMAP-Rule:MF_01810}.
FT TRANSMEM 12..29
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01810"
FT TRANSMEM 353..373
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01810"
FT TRANSMEM 416..439
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01810"
FT TRANSMEM 459..476
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01810"
FT TRANSMEM 496..516
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01810"
FT DOMAIN 155..341
FT /note="Membrane insertase YidC N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14849"
FT DOMAIN 353..532
FT /note="Membrane insertase YidC/Oxa/ALB C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02096"
FT REGION 38..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 548 AA; 62863 MW; 3D4EE7493B64FC71 CRC64;
MDRNNNNNLR LILAIALSFL FIALYSYFFQ KPNKTTTQTT KQETTNNHTA TSPNAPNAQH
FSTTQTTPQE SLLSTISFEH ARIEIDSLGR IKQVYLKDKK YLTPKQKGFL EHVGHLFSSK
ENMQPPLKEL PLLAADKLKP LEVRFLDPTL NNKAFNTPYS ASKTTLGPNE QLVLTQDLGA
FTIIKTLTFY DDLHYDLKIA FKSPNNLIPS YVITNGYRPV ADLDSYTFSG VLLENNDKKI
EKIEDKDAKE IKRFSNTLFL SSVDRYFTTL LFTKDPQGFE ALIDSEIGTK NPLGFISLKN
EANLHGYIGP KDYRSLKAIS PMLTDVIEYG LITFFAKGVF VLLDYLYQFV GNWGWAIIFL
TIIVRIILYP LSYKGMVSMQ KLKELAPKMK ELQEKYKGEP QKLQAHMMQL YKKHGANPLG
GCLPLILQIP VFFAIYRVLY NAVELKSSEW ILWIHDLSIM DPYFILPLLM GASMYWHQSV
TPNTMTDPMQ AKIFKFLPLL FTIFLITFPA GLVLYWTTNN ILSVLQQLII NKILENKKRM
HAQNKKEN
//
