ID IWS1_EMENI Reviewed; 469 AA.
AC Q5BEG5; C8VTP1;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 16-NOV-2011, sequence version 2.
DT 24-JAN-2024, entry version 94.
DE RecName: Full=Transcription factor iws1;
GN Name=iws1; ORFNames=AN1065;
OS Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS M139) (Aspergillus nidulans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Nidulantes.
OX NCBI_TaxID=227321;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=16372000; DOI=10.1038/nature04341;
RA Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT fumigatus and A. oryzae.";
RL Nature 438:1105-1115(2005).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA Oliver S.G., Turner G.;
RT "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT effort.";
RL Fungal Genet. Biol. 46:S2-13(2009).
CC -!- FUNCTION: Transcription factor involved in RNA polymerase II
CC transcription regulation. May function in both SPT15/TBP post-
CC recruitment and recruitment steps of transcription (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00649}.
CC -!- SIMILARITY: Belongs to the IWS1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EAA66183.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AACD01000016; EAA66183.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BN001308; CBF88223.1; -; Genomic_DNA.
DR RefSeq; XP_658669.1; XM_653577.1.
DR AlphaFoldDB; Q5BEG5; -.
DR SMR; Q5BEG5; -.
DR STRING; 227321.Q5BEG5; -.
DR EnsemblFungi; CBF88223; CBF88223; ANIA_01065.
DR KEGG; ani:AN1065.2; -.
DR eggNOG; KOG1793; Eukaryota.
DR HOGENOM; CLU_045275_1_0_1; -.
DR InParanoid; Q5BEG5; -.
DR OMA; RNNVQHA; -.
DR OrthoDB; 12240at2759; -.
DR Proteomes; UP000000560; Chromosome VIII.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IBA:GO_Central.
DR Gene3D; 1.20.930.10; Conserved domain common to transcription factors TFIIS, elongin A, CRSP70; 1.
DR InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR InterPro; IPR017923; TFIIS_N.
DR PANTHER; PTHR46010; PROTEIN IWS1 HOMOLOG; 1.
DR PANTHER; PTHR46010:SF1; PROTEIN IWS1 HOMOLOG; 1.
DR Pfam; PF08711; Med26; 1.
DR SUPFAM; SSF47676; Conserved domain common to transcription factors TFIIS, elongin A, CRSP70; 1.
DR PROSITE; PS51319; TFIIS_N; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..469
FT /note="Transcription factor iws1"
FT /id="PRO_0000083359"
FT DOMAIN 284..361
FT /note="TFIIS N-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00649"
FT REGION 1..193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 444..469
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 62..78
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 79..109
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 110..144
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 151..193
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 469 AA; 52992 MW; F045BB5EEDA2E643 CRC64;
MSASPSRSPE SKPAGNTPPI DVDVENEQNV DAEEAVQPPT PGAGGDDADA DDNDAKPAVD
NEIDNDNTNL NENEGQNELN EDNLGDSDDE SILSEVDEAQ FEDFDPENVD IEDRPQLDID
EENLKLIGRH KRKRTEEEGT SKRKKEGRRR KSRRYAEEEE GGSDREAGGK RRKSKKAELE
EDEETLDPAT RRRRALDRAM DEALKKPTKR RARKQDGIDL EQMADAEIED MRKRMTHAAQ
MDAINRREGK PAMHKLKMLP EVVSLLNRNQ YVNSLVDPEI NLLEAVKFFL EPLDDGSLPA
YNIQRDLMTA LGKLPINKET LIASGIGKVV VFYTRSKRPE PGIKRMAERL LAEWTRPILQ
RSDDYSKRVY QEAEFDPTYV LSPFLLKITS RVKSVQDSAA EARARELLPP RLANRARAEI
SHTSYTVVPK PTVVQESKFA RPLGASGEDR FRKMRARQIA ATKGQGARR
//
