ID IWS1_YARLI Reviewed; 414 AA.
AC Q6CGB2;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 24-JAN-2024, entry version 98.
DE RecName: Full=Transcription factor IWS1;
GN Name=IWS1; OrderedLocusNames=YALI0A20724g;
OS Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Dipodascaceae; Yarrowia.
OX NCBI_TaxID=284591;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CLIB 122 / E 150;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Transcription factor involved in RNA polymerase II
CC transcription regulation. May function in both SPT15/TBP post-
CC recruitment and recruitment steps of transcription (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00649}.
CC -!- SIMILARITY: Belongs to the IWS1 family. {ECO:0000305}.
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DR EMBL; CR382127; CAG84238.1; -; Genomic_DNA.
DR RefSeq; XP_500300.1; XM_500300.1.
DR AlphaFoldDB; Q6CGB2; -.
DR SMR; Q6CGB2; -.
DR STRING; 284591.Q6CGB2; -.
DR EnsemblFungi; CAG84238; CAG84238; YALI0_A20724g.
DR GeneID; 2905784; -.
DR KEGG; yli:YALI0A20724g; -.
DR VEuPathDB; FungiDB:YALI0_A20724g; -.
DR HOGENOM; CLU_045275_0_0_1; -.
DR InParanoid; Q6CGB2; -.
DR OMA; VAEWTRP; -.
DR OrthoDB; 12240at2759; -.
DR Proteomes; UP000001300; Chromosome A.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IBA:GO_Central.
DR Gene3D; 1.20.930.10; Conserved domain common to transcription factors TFIIS, elongin A, CRSP70; 1.
DR InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR InterPro; IPR017923; TFIIS_N.
DR PANTHER; PTHR46010; PROTEIN IWS1 HOMOLOG; 1.
DR PANTHER; PTHR46010:SF1; PROTEIN IWS1 HOMOLOG; 1.
DR Pfam; PF08711; Med26; 1.
DR PROSITE; PS51319; TFIIS_N; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..414
FT /note="Transcription factor IWS1"
FT /id="PRO_0000083365"
FT DOMAIN 228..305
FT /note="TFIIS N-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00649"
FT REGION 1..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 395..414
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..46
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..84
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..112
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 113..138
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 414 AA; 46235 MW; 1575721C65E7D43A CRC64;
MSDTEKPIKS EEPVDEGVDR VDEEENVEEP AEDVGEAAEE ASEAPEEAPA EAATTTEAAP
ADDDEDDSDL SDLDEDEIKN AAIEDDDDDY NKLSAHRRKV QSSGKKTLKK RATKDSRAAD
DDEDEIDHSH IDLDPSMARR REIEARIDAA MKPASQRRKK LGEDDIEMMQ DERISNLREK
MRNAAIADAE SNREGQPATH KLQLLPEVKD VLQKHHLADS ILDNNLLEAV RIWLEPLPDA
SLPSYSIQEE LFDALVRLPI KSIHLRESGL GKVVTFYRKS KQPQLRIKRI ADKLVADWTR
PIMGRSDNYR EKVVSTRSFD PSTQEIALAV AAKRAQTLKD GTLAEKQAER RRRAHIPSAQ
PANYRVAPKS EIIPQNRGGS TNDMTFKRLK GKLGVTKTGK KKSGVSIEGR GLNG
//
