ID   J0D4B2_9BIFI            Unreviewed;       798 AA.
AC   J0D4B2;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   27-MAR-2024, entry version 45.
DE   SubName: Full=Anaerobic ribonucleoside-triphosphate reductase {ECO:0000313|EMBL:EJD64810.1};
GN   ORFNames=HMPREF9156_00685 {ECO:0000313|EMBL:EJD64810.1};
OS   Scardovia wiggsiae F0424.
OC   Bacteria; Actinomycetota; Actinomycetes; Bifidobacteriales;
OC   Bifidobacteriaceae; Scardovia.
OX   NCBI_TaxID=857290 {ECO:0000313|EMBL:EJD64810.1, ECO:0000313|Proteomes:UP000006415};
RN   [1] {ECO:0000313|EMBL:EJD64810.1, ECO:0000313|Proteomes:UP000006415}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=F0424 {ECO:0000313|EMBL:EJD64810.1,
RC   ECO:0000313|Proteomes:UP000006415};
RG   The Broad Institute Genome Sequencing Platform;
RA   Earl A., Ward D., Feldgarden M., Gevers D., Izard J., Ganesan A.,
RA   Baranova O.V., Blanton J.M., Tanner A.C., Mathney J., Dewhirst F.E.,
RA   Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A.,
RA   Alvarado L., Arachchi H.M., Berlin A., Chapman S.B., Gearin G.,
RA   Goldberg J., Griggs A., Gujja S., Hansen M., Heiman D., Howarth C.,
RA   Larimer J., Lui A., MacDonald P.J.P., McCowen C., Montmayeur A., Murphy C.,
RA   Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T., Sisk P.,
RA   Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Scardovia wiggsiae F0424.";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EJD64810.1}.
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DR   EMBL; AGZS01000003; EJD64810.1; -; Genomic_DNA.
DR   RefSeq; WP_007147749.1; NZ_JH719939.1.
DR   AlphaFoldDB; J0D4B2; -.
DR   STRING; 857290.HMPREF9156_00685; -.
DR   GeneID; 84815613; -.
DR   eggNOG; COG1328; Bacteria.
DR   HOGENOM; CLU_002707_2_0_11; -.
DR   OrthoDB; 9804622at2; -.
DR   Proteomes; UP000006415; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008998; F:ribonucleoside-triphosphate reductase activity; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR   CDD; cd01675; RNR_III; 1.
DR   Gene3D; 3.20.70.20; -; 1.
DR   InterPro; IPR005144; ATP-cone_dom.
DR   InterPro; IPR019777; Form_AcTrfase_GR_CS.
DR   InterPro; IPR001150; Gly_radical.
DR   InterPro; IPR012833; NrdD.
DR   NCBIfam; TIGR02487; NrdD; 1.
DR   PANTHER; PTHR21075; ANAEROBIC RIBONUCLEOSIDE-TRIPHOSPHATE REDUCTASE; 1.
DR   PANTHER; PTHR21075:SF0; ANAEROBIC RIBONUCLEOSIDE-TRIPHOSPHATE REDUCTASE; 1.
DR   Pfam; PF03477; ATP-cone; 1.
DR   Pfam; PF13597; NRDD; 1.
DR   SUPFAM; SSF51998; PFL-like glycyl radical enzymes; 1.
DR   PROSITE; PS51161; ATP_CONE; 1.
DR   PROSITE; PS00850; GLY_RADICAL_1; 1.
DR   PROSITE; PS51149; GLY_RADICAL_2; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00492};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00492};
KW   Organic radical {ECO:0000256|ARBA:ARBA00022818, ECO:0000256|PROSITE-
KW   ProRule:PRU00493}; Reference proteome {ECO:0000313|Proteomes:UP000006415}.
FT   DOMAIN          20..115
FT                   /note="ATP-cone"
FT                   /evidence="ECO:0000259|PROSITE:PS51161"
FT   DOMAIN          652..778
FT                   /note="Glycine radical"
FT                   /evidence="ECO:0000259|PROSITE:PS51149"
FT   MOD_RES         751
FT                   /note="Glycine radical"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00493"
SQ   SEQUENCE   798 AA;  90452 MW;  660DCE4986640FEF CRC64;
     MDQLVAEETV VREPAVTESV KVEKRDGRVV PFDSVNIIHA IKSAFSAVNA EVGPEEERGI
     EQMAQRVESA ITGRYNGPVR IDDIQSLVER ELVNDHLYDI AKAYTSYRLD KDIRRAKASD
     VNEAIKKLVN KDESLVRENA NKDSNVYATQ RDLLAGTVSK ASAMNMLPAD VANAHLKGDI
     HFHDADYSPF TPMTNCSLPN FGDMLKNGFE LGNAMMDSPK SIGTAATQIT QIIKDIAGSQ
     YGGQTVNRAD EMLAEYAKLD YAKNLDTARA IFPDGEDISL ARTIVEGFKE REPKWLHFEN
     REPLPMDEPF TGDADELEQI REIYAKIMTR KNIYDAMQTM EYQINSNRVS NGQTPFVTVG
     FGLGTDWFAR EIQRAIFLIR IRGLGKDRHT AIFPKLVYTV KHGLNDKEGT PNYDMKQLAL
     ECSTKRMYPD IVFYENIVKI TGSFKAPMGC RSFLNGWTDP DTGEDVEDSR LNLGVVTVNI
     PRIALESHGD KDRFWKLFSQ RMEVAHEALQ FRIKRCKEAT PINAPTLFEH GAFGRLKPTD
     NVDVLYNRSR ATVSLGYIGL YEATAMFYGK DWMTDHSWDP EGKEFALEIV RRMHDLCVDW
     DNAEGYHYSV YSTPAESLTD RFARMDREKF GDIDGVTDHD FYTNSFHYPV WLRPTPMEKL
     SYERDFPYLA NGGFINYCEF PSLQQNPKAL EAVWDYAHNI GIGYLGTNTP IDHCFECGFE
     GDFEPTELGF KCPECGNADP EKCNVTKRTC GYLGNPVQRP MVHGRHEEIA HRVKHMAGET
     GHVTLSNGTV KEWWDEAK
//