ID J0D9A1_AURST Unreviewed; 684 AA.
AC J0D9A1;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=AURDEDRAFT_147223 {ECO:0000313|EMBL:EJD36361.1};
OS Auricularia subglabra (strain TFB-10046 / SS5) (White-rot fungus)
OS (Auricularia delicata (strain TFB10046)).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Auriculariales; Auriculariaceae; Auricularia.
OX NCBI_TaxID=717982 {ECO:0000313|EMBL:EJD36361.1, ECO:0000313|Proteomes:UP000006514};
RN [1] {ECO:0000313|Proteomes:UP000006514}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TFB10046 {ECO:0000313|Proteomes:UP000006514};
RX PubMed=22745431; DOI=10.1126/science.1221748;
RA Floudas D., Binder M., Riley R., Barry K., Blanchette R.A., Henrissat B.,
RA Martinez A.T., Otillar R., Spatafora J.W., Yadav J.S., Aerts A., Benoit I.,
RA Boyd A., Carlson A., Copeland A., Coutinho P.M., de Vries R.P.,
RA Ferreira P., Findley K., Foster B., Gaskell J., Glotzer D., Gorecki P.,
RA Heitman J., Hesse C., Hori C., Igarashi K., Jurgens J.A., Kallen N.,
RA Kersten P., Kohler A., Kuees U., Kumar T.K.A., Kuo A., LaButti K.,
RA Larrondo L.F., Lindquist E., Ling A., Lombard V., Lucas S., Lundell T.,
RA Martin R., McLaughlin D.J., Morgenstern I., Morin E., Murat C., Nagy L.G.,
RA Nolan M., Ohm R.A., Patyshakuliyeva A., Rokas A., Ruiz-Duenas F.J.,
RA Sabat G., Salamov A., Samejima M., Schmutz J., Slot J.C., St John F.,
RA Stenlid J., Sun H., Sun S., Syed K., Tsang A., Wiebenga A., Young D.,
RA Pisabarro A., Eastwood D.C., Martin F., Cullen D., Grigoriev I.V.,
RA Hibbett D.S.;
RT "The Paleozoic origin of enzymatic lignin decomposition reconstructed from
RT 31 fungal genomes.";
RL Science 336:1715-1719(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the helicase family. RAD25/XPB subfamily.
CC {ECO:0000256|ARBA:ARBA00006637}.
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DR EMBL; JH687863; EJD36361.1; -; Genomic_DNA.
DR RefSeq; XP_007355525.1; XM_007355463.1.
DR AlphaFoldDB; J0D9A1; -.
DR KEGG; adl:AURDEDRAFT_147223; -.
DR eggNOG; KOG1123; Eukaryota.
DR InParanoid; J0D9A1; -.
DR OrthoDB; 1360679at2759; -.
DR Proteomes; UP000006514; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR GO; GO:0006367; P:transcription initiation at RNA polymerase II promoter; IEA:InterPro.
DR CDD; cd18029; DEXHc_XPB; 1.
DR CDD; cd18789; SF2_C_XPB; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR032438; ERCC3_RAD25_C.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001161; XPB/Ssl2.
DR InterPro; IPR032830; XPB/Ssl2_N.
DR NCBIfam; TIGR00603; rad25; 1.
DR PANTHER; PTHR11274:SF0; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB; 1.
DR PANTHER; PTHR11274; RAD25/XP-B DNA REPAIR HELICASE; 1.
DR Pfam; PF16203; ERCC3_RAD25_C; 1.
DR Pfam; PF13625; Helicase_C_3; 1.
DR Pfam; PF04851; ResIII; 1.
DR PRINTS; PR00851; XRODRMPGMNTB.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:EJD36361.1};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:EJD36361.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022806,
KW ECO:0000313|EMBL:EJD36361.1}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000006514}.
FT DOMAIN 273..435
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 489..643
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 168..190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 684 AA; 77419 MW; 6DCA38FE2D206957 CRC64;
MDSACGSPGF AAVRRGEASR VHRAIIERCL NSLPLKAGHD SRPLWVCENH SIVFERFSPF
AEQVQDFLIA IAEPVSRPEF IHEYQLTTSS LYAAASVGLK TAEIIDVLSR FSKTPLPPST
IEFIRDCTVS YGKVQLVLKN SKYFIESKHA EIIQRLLKDP VVGTARATAD GADAGSRSET
PARPKMSGVA PLPANRLEER LNTEYNDDED ERSYGFQIDL NKIDEVKKRC NDLGFPMLQE
YDFRKDVINR NLNIRLTTSG FVRPYQETSL RKMFGNGRAR SGIIVLPCGA GKTLVGVMAA
GTINKSCLVL CTSAVSAGQW RHQFKLWAQI KDSQISLFTS EEQKEFQAPS GVLISTYSMI
ANTRKRSRDA ERKMEFVSSR EWGLVILDEV HVVPANTFRL VFGSIKAHAK LGLTATLVRE
DDKIVDLDHL IGPKLYEANW KDLAAQGHIA NVLCAEVQCP MSPEFYHQYL RATSLKKTLL
HCMNPTKLQA CQYLMDYHER RGDKIIVFSD NVFALEYYAR KLKRLFIHGK VSQVERELIL
ERFKEDPDIK TIFLSKVGDT SLDIPEATCL IQISSHFGSR RQEAQRLGRI LRAKRRSEEG
FNAYFYSLVS KDTDEMVFST KRQQFLVDQG YAFKVITRLD GIERFPGLAF RTIDERWALL
REVYHAQEKD GETGNDVAVT LEVA
//
