ID J0IQT8_HELPX Unreviewed; 1083 AA.
AC J0IQT8;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=HPNQ4099_1648 {ECO:0000313|EMBL:EJB27810.1};
OS Helicobacter pylori NQ4099.
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=992026 {ECO:0000313|EMBL:EJB27810.1, ECO:0000313|Proteomes:UP000003402};
RN [1] {ECO:0000313|EMBL:EJB27810.1, ECO:0000313|Proteomes:UP000003402}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NQ4099 {ECO:0000313|EMBL:EJB27810.1,
RC ECO:0000313|Proteomes:UP000003402};
RX PubMed=23661595; DOI=10.1111/2049-632X.12045;
RA Blanchard T.G., Czinn S.J., Correa P., Nakazawa T., Keelan M.,
RA Morningstar L., Santana-Cruz I., Maroo A., McCracken C., Shefchek K.,
RA Daugherty S., Song Y., Fraser C.M., Fricke W.F.;
RT "Genome sequences of 65 Helicobacter pylori strains isolated from
RT asymptomatic individuals and patients with gastric cancer, peptic ulcer
RT disease, or gastritis.";
RL Pathog. Dis. 68:39-43(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00006594}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJB27810.1}.
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DR EMBL; AKNU01000006; EJB27810.1; -; Genomic_DNA.
DR AlphaFoldDB; J0IQT8; -.
DR PATRIC; fig|992026.3.peg.1598; -.
DR Proteomes; UP000003402; Unassembled WGS sequence.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 2.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR011639; MethylTrfase_TaqI-like_dom.
DR InterPro; IPR046816; MmeI_Mtase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR025931; TaqI_C.
DR PANTHER; PTHR33841:SF1; ADENINE-SPECIFIC METHYLTRANSFERASE PGLX; 1.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR Pfam; PF07669; Eco57I; 1.
DR Pfam; PF20473; MmeI_Mtase; 1.
DR Pfam; PF12950; TaqI_C; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:EJB27810.1};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EJB27810.1}.
FT DOMAIN 307..464
FT /note="MmeI-like DNA-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF20473"
FT DOMAIN 629..738
FT /note="Type II methyltransferase M.TaqI-like"
FT /evidence="ECO:0000259|Pfam:PF07669"
FT DOMAIN 851..1021
FT /note="TaqI-like C-terminal specificity"
FT /evidence="ECO:0000259|Pfam:PF12950"
SQ SEQUENCE 1083 AA; 126663 MW; 0585BDB79499B425 CRC64;
MKYHHISLKK ENLALIYQAL SPNFLLKIPK YSDANTLNKD FYEELLYILG LEEQNEKGKI
LIKPSRTQNS LSYALKEQYK NLDDEEVMAL LIAWNNRILF LRLLESLLIS FEHFENPFLT
TENFNDFNAL NTLFFEVLAK KNNERSKEIK EDKILEKIPY LNSSLFDQTP LELKGYEIKL
LDNKKLEIYK NSVLKKHEDY QKEKALPLLK YLFEFLRVYD FTTTPKDIKD NQNKSESRLI
NPSVLGLVFE KLNGYKEGSF YTPSFITSYM CKESITTIVR DKFNAIYQWD CENLEALREK
IDRNFSNEKA KEYLNTLLTL RICDPAVGSG HFLVSALNEM VLIAYELGLI ASLYRHELRL
ENDEIIIHYT PTGEIFNYKK PDSENDPHHH IQKELFNLKK DIIENCLFGV DINPNSCEIT
KLRLWIELLK YSYYIFEEGK NTNNLETLPN IDINIKCANS LIFNFPLNSK LTIGQTLEFS
KNLKAEIKEY KNSVMLYKEG LGEKTKILQN IAKLKSLIIN YFIEQHQAKK HLKESLKAFI
SEYGDGIFDI GTAFGMEMLK IARLKENNYR FNPTLTKKQP SPIGVEANRL LIKIKECYET
LENLKNSKAF EWRFEFPEVL NDEGDFLGFD CIIGNPPYIR QEQIKDLKPL LAKQYQDFYN
STADIYTYFF ALSYHLLKDK GFSAFITSNK YARAKYGAKL REWLLKKTTL VRYMELNALK
VFESAAVDTS IIHFIKQTPP KESDFKYYEP TPNDKDDLKS TPSLSMKQNA LSTESFIFAN
ATLLDLRDKI EQSGTPLKDW DIQINYGIKT GANEAFIIPT EKRDEILKNC DDAQKDERGM
SERERTKELI KPILRGKDIK RYSYEWAGEW IIFIPWHFPN TDSQKSMEEN EQDFSIHYPI
IYAHLLSHKD ELLKRNKDET GKRYEWYCLQ RWAASYYQDF EKEKIVYPET SQGAYFIYEN
SGIFLEKTAF MIVSDAYNLK LLTALLNSKL VTFYFKNFCG GCILGKSGYQ YNKHALEKIP
IPKITTKNQE LADKITDGAK QILALKEKDP KANTQELEKE IDALVYQLYH LTDEEIKIIE
DGQ
//