ID   J0MQ28_HELPX            Unreviewed;       675 AA.
AC   J0MQ28;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   SubName: Full=Methyl-accepting chemotaxis protein {ECO:0000313|EMBL:EJB76247.1};
DE            EC=4.2.3.1 {ECO:0000313|EMBL:EJB76247.1};
GN   Name=tlpA {ECO:0000313|EMBL:EJB76247.1};
GN   ORFNames=HPHPA26_0132 {ECO:0000313|EMBL:EJB76247.1};
OS   Helicobacter pylori Hp A-26.
OC   Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=992056 {ECO:0000313|EMBL:EJB76247.1, ECO:0000313|Proteomes:UP000005323};
RN   [1] {ECO:0000313|EMBL:EJB76247.1, ECO:0000313|Proteomes:UP000005323}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hp A-26 {ECO:0000313|EMBL:EJB76247.1,
RC   ECO:0000313|Proteomes:UP000005323};
RX   PubMed=23661595; DOI=10.1111/2049-632X.12045;
RA   Blanchard T.G., Czinn S.J., Correa P., Nakazawa T., Keelan M.,
RA   Morningstar L., Santana-Cruz I., Maroo A., McCracken C., Shefchek K.,
RA   Daugherty S., Song Y., Fraser C.M., Fricke W.F.;
RT   "Genome sequences of 65 Helicobacter pylori strains isolated from
RT   asymptomatic individuals and patients with gastric cancer, peptic ulcer
RT   disease, or gastritis.";
RL   Pathog. Dis. 68:39-43(2013).
CC   -!- SIMILARITY: Belongs to the methyl-accepting chemotaxis (MCP) protein
CC       family. {ECO:0000256|ARBA:ARBA00029447}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EJB76247.1}.
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DR   EMBL; AKOV01000001; EJB76247.1; -; Genomic_DNA.
DR   RefSeq; WP_000033509.1; NZ_AKOV01000001.1.
DR   AlphaFoldDB; J0MQ28; -.
DR   PATRIC; fig|992056.3.peg.130; -.
DR   Proteomes; UP000005323; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004795; F:threonine synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.287.950; Methyl-accepting chemotaxis protein; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 1.
DR   InterPro; IPR004089; MCPsignal_dom.
DR   PANTHER; PTHR32089:SF112; HEME-BASED AEROTACTIC TRANSDUCER HEMAT; 1.
DR   PANTHER; PTHR32089; METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPB; 1.
DR   Pfam; PF00015; MCPsignal; 1.
DR   SMART; SM00283; MA; 1.
DR   SUPFAM; SSF58104; Methyl-accepting chemotaxis protein (MCP) signaling domain; 1.
DR   PROSITE; PS50111; CHEMOTAXIS_TRANSDUC_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils}; Lyase {ECO:0000313|EMBL:EJB76247.1};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|PROSITE-
KW   ProRule:PRU00284}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        302..322
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          475..675
FT                   /note="Methyl-accepting transducer"
FT                   /evidence="ECO:0000259|PROSITE:PS50111"
FT   COILED          586..641
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   675 AA;  74985 MW;  A7366D5F5894712A CRC64;
     MSKGLSIGNK IILCVALIVI VCVSILGVSL NSRVKEILKE SALHSMQDSL HFKVKEVQGV
     LENTYTSIGI VKEMLPKDTK REIKIQLLKN FILANSHVAG VSMFFKDRED LRLMLLRDND
     TIKLMENPSL GNNPLVQKAM KNKEISKSLP YYRKMPNGAE VYGVDILLPL FKENTQEVVG
     VLMTFFSIDS FSNEITKNRS DLFLIGVKGK VLLSANKSLQ DKSITEIYKS VPKATNEVMV
     ILENGSKATL EYLDPFSHKE NFLAVETFKM LGKTESKDNL NWMIALIIEK DKVYEQVGSV
     RFVVVVASVI MVLALIIAIT LLMRAIVSNR LEVVSSTLSH FFKLLNNQAH SSDIKLVEAR
     SNDELGRMQT AINKNILQTQ KIMQEDKQAV QDTIKVVSDV KAGNFAVRIT AEPASPDLKE
     LRDALNGIMD YLQESVGTHM PSIFKIFESY SGLDFRGRIQ NASGRVELVT NALGQEIQKM
     LETSSNFAKD LANDSANLKE CVQNLEKASN SQHKSLMETS KTIENITTSI QGVSSQSEAM
     IEQGQDIKSI VEIIRDIADQ TNLLALNAAI EAARAGEHGR GFAVVADEVR KLAERTQKSL
     SEIEANINIL VQSISDTSES IKNQVKEVEE INASIEALRS VIEGNLKIAS DSLEISQEID
     KVSNDILEDV NKKQF
//