ID J0N504_9ACTO Unreviewed; 666 AA.
AC J0N504;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Histidine kinase dimerization/phosphoacceptor domain protein {ECO:0000313|EMBL:EJF39512.1};
GN ORFNames=HMPREF1318_0091 {ECO:0000313|EMBL:EJF39512.1};
OS Actinomyces massiliensis F0489.
OC Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC Actinomyces.
OX NCBI_TaxID=1125718 {ECO:0000313|EMBL:EJF39512.1, ECO:0000313|Proteomes:UP000002941};
RN [1] {ECO:0000313|EMBL:EJF39512.1, ECO:0000313|Proteomes:UP000002941}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0489 {ECO:0000313|EMBL:EJF39512.1,
RC ECO:0000313|Proteomes:UP000002941};
RA Harkins D.M., Madupu R., Durkin A.S., Torralba M., Methe B., Sutton G.G.,
RA Nelson K.E.;
RL Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJF39512.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AKFT01000177; EJF39512.1; -; Genomic_DNA.
DR AlphaFoldDB; J0N504; -.
DR PATRIC; fig|1125718.3.peg.2260; -.
DR eggNOG; COG2203; Bacteria.
DR eggNOG; COG4585; Bacteria.
DR OrthoDB; 5241249at2; -.
DR Proteomes; UP000002941; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR Gene3D; 1.20.5.1930; -; 1.
DR Gene3D; 3.30.450.40; -; 2.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR011712; Sig_transdc_His_kin_sub3_dim/P.
DR PANTHER; PTHR24421; NITRATE/NITRITE SENSOR PROTEIN NARX-RELATED; 1.
DR PANTHER; PTHR24421:SF56; OXYGEN SENSOR HISTIDINE KINASE RESPONSE REGULATOR DOST; 1.
DR Pfam; PF01590; GAF; 1.
DR Pfam; PF13185; GAF_2; 1.
DR Pfam; PF07730; HisKA_3; 1.
DR SMART; SM00065; GAF; 2.
DR SMART; SM00387; HATPase_c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF55781; GAF domain-like; 2.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:EJF39512.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002941};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT DOMAIN 93..232
FT /note="GAF"
FT /evidence="ECO:0000259|SMART:SM00065"
FT DOMAIN 253..399
FT /note="GAF"
FT /evidence="ECO:0000259|SMART:SM00065"
FT DOMAIN 542..663
FT /note="Histidine kinase/HSP90-like ATPase"
FT /evidence="ECO:0000259|SMART:SM00387"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 666 AA; 69842 MW; 9A92AB47B64211A6 CRC64;
MTEMPEIPEM TEMPEPNSRP DPAVFPGVPD DDLVLALPSS PSPDDPAGIG SLAYAIHTDN
LASTREHPSR GVNLDSGTIE LFRAALRLTG SLNMPDALRH LVESACSITG AAWGTIGVLG
TTGSPSLATA RATASPSELD SMLTGARRVG PADGGVIVDN DLPAAAFTGQ IEGETTGSVL
SAPLRVHGHL YGRLYLCDKD GGFDDGDAAI VLTLAEAAAV AVENARLYRE ARDRERWMAV
SQELTTLLLS GAEEDDALTL IAHRVREVAH ADTAALILPS VGQTWVCEIA AGAHSAGLIG
TAFPAEGRAL TTLAHQTGMT VDSLAEAWGA HDLLVPELAA FGPALYAPMI HRGRGVGVML
LLRAQGAAPF TKQDLEIAEL VAGQATMAFE LADAQHAEEM ATLLNERARI GRDLHDLAIQ
QLFATGMQIS AARDRLRAHS PDHADGAGGP VDLTSACGAL ESSLEAVDDS VRQIRSIVRS
LRDRDEDVSV VERLRREASL ARTSLGFAPS LILTIDGRGL AQTGRQEEDE LIDALDAAVE
PDIADDIVAV VREGLSNVAR HAKASSVTVD VKIEGVLPGD SSLLTADGPA SGNAEPFHGV
PVVEVVCRDD GIGVNPSVTR RSGTANMAER ARRHGGTFAI GPRARSDGER RGTCFTWRVP
LGPALG
//
